WormBase Tree Display for Gene: WBGene00004990
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| WBGene00004990 | SMap | S_parent | Sequence | T08A9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | spp-5 | |||||||
| Sequence_name | T08A9.9 | ||||||||
| Molecular_name | T08A9.9 | ||||||||
| T08A9.9.1 | |||||||||
| CE33825 | |||||||||
| Other_name | CELE_T08A9.9 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | spp-5 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00004990 | |||||
| WormFlux | gene | WBGene00004990 | |||||||
| NDB | locus_tag | CELE_T08A9.9 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004990|UniProtKB=Q86FL8 | |||||||
| family | PTHR21579 | ||||||||
| NCBI | gene | 180994 | |||||||
| RefSeq | protein | NM_076837.8 | |||||||
| TREEFAM | TREEFAM_ID | TF343148 | |||||||
| TrEMBL | UniProtAcc | Q86FL8 | |||||||
| UniProt_GCRP | UniProtAcc | Q86FL8 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | spp | ||||||||
| Allele (13) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00083250 | ||||||||
| 00083251 | |||||||||
| 00083252 | |||||||||
| 00083253 | |||||||||
| Ortholog (25) | |||||||||
| Paralog (12) | |||||||||
| Structured_description | Concise_description | spp-5 encodes a caenopore, a saposin (B) domain-containing protein that is a member of the saposin-like protein (SAPLIP) superfamily containing mammalian NK-lysin and granulysin and the protozoan amoebapore-like proteins; SPP-5 exhibits pore-forming activity and functions as an effector of innate immunity, demonstrating antimicrobial activity against both Gram-positive and Gram-negative bacteria; in addition, SPP-5 is also required for fully normal postembryonic growth and reproduction, likely as a result of its role in killing ingested food, such as E. coli OP50; Northern blot analysisindicates that spp-5 mRNA is expressed constitutively at high levels in the presence of OP50 and a variety of other bacteria; an SPP-5::GFP reporter fusion is expressed exclusively in the intestine; the three-dimensional solution structure of SPP-5 has been determined by NMR spectroscopy revealing five helices, connected by three disulfide bonds, arranged in a folded leaf, the characteristic signature of the SAPLIP family. | Paper_evidence | WBPaper00003435 | |||||
| WBPaper00035289 | |||||||||
| WBPaper00035472 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 14 Sep 2010 00:00:00 | ||||||||
| Automated_description | Enables channel activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T08A9.9 | |||||||
| Corresponding_CDS_history | T08A9.9a:wp145 | ||||||||
| T08A9.9b:wp145 | |||||||||
| Corresponding_transcript | T08A9.9.1 | ||||||||
| Other_sequence | CBC16708_1 | ||||||||
| CBC03827_1 | |||||||||
| CBC16246_1 | |||||||||
| CJC03007_1 | |||||||||
| Associated_feature | WBsf654126 | ||||||||
| WBsf237571 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00001969 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00082201 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00018423 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00075982 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00082195 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00082196 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00082194 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00082203 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr12823 | ||||||||
| Expr1014643 | |||||||||
| Expr1032483 | |||||||||
| Expr1156432 | |||||||||
| Expr2016083 | |||||||||
| Expr2034319 | |||||||||
| Drives_construct | WBCnstr00022886 | ||||||||
| WBCnstr00023104 | |||||||||
| WBCnstr00035287 | |||||||||
| Construct_product | WBCnstr00022886 | ||||||||
| WBCnstr00035287 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (234) | |||||||||
| Interaction | WBInteraction000134108 | ||||||||
| WBInteraction000134112 | |||||||||
| WBInteraction000134113 | |||||||||
| WBInteraction000134116 | |||||||||
| WBInteraction000134193 | |||||||||
| WBInteraction000450461 | |||||||||
| WBInteraction000452360 | |||||||||
| WBInteraction000550093 | |||||||||
| Map_info | Map | X | Position | -1.77287 | Error | 0.00333 | |||
| Positive | Positive_clone | T08A9 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00003435 | ||||||||
| WBPaper00006437 | |||||||||
| WBPaper00024209 | |||||||||
| WBPaper00024994 | |||||||||
| WBPaper00035289 | |||||||||
| WBPaper00035472 | |||||||||
| WBPaper00046055 | |||||||||
| WBPaper00061547 | |||||||||
| WBPaper00064841 | |||||||||
| WBPaper00064949 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
