WormBase Tree Display for Gene: WBGene00004984

WBGene00004984 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: ZC404
  Identity: Version: 1
    Name: CGC_name: spn-4 Person_evidence: WBPerson534
      Sequence_name: ZC404.8
      Molecular_name: ZC404.8
        ZC404.8.1
        CE07598
      Other_name: gei-20
        pip-1 Author_evidence: Ogura K-i
        CELE_ZC404.8 Accession_evidence: NDB BX284605
      Public_name: spn-4
    DB_info: Database: AceView gene 5H264
        WormQTL gene WBGene00004984
        WormFlux gene WBGene00004984
        NDB locus_tag CELE_ZC404.8
        Panther gene CAEEL|WormBase=WBGene00004984|UniProtKB=G5EF02
          family PTHR15597
        NCBI gene 179070
        RefSeq protein NM_072316.7
        TREEFAM TREEFAM_ID TF315942
        TrEMBL UniProtAcc G5EF02
        UniProt_GCRP UniProtAcc G5EF02
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:37 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: spn
    Allele (44)
    Legacy_information: [Bowerman BA] temperature-sensitive embryonic lethal, permissive = 15 C, restrictive = 25 C. spindle orientation defects
      [JE Gomes] Defective orientation of the mitotic spindle at 2-cell stage. Patternig defects: reduced gut and pharynx, excess of body wall muscle and germline
      [Gomes JE] RNAi phenotype mimics mutant alleles phenotype. or191ts is temperature sensitive, viable at 15C and embrionic lethal at 25C. Transformation rescue was done with or191ts. or25 and or191ts are point mutations resulting in single amino acid changes in the RNA Recognition Motif.or80 is a deletion in the 3'UTR
      [Gomes JE] or191 homozygotes have temperature-sensitive defects in mitotic spindle orientation during early embryonic divisions.
    Strain: WBStrain00005730
      WBStrain00007269
      WBStrain00007289
      WBStrain00007303
      WBStrain00007304
      WBStrain00007327
      WBStrain00007329
      WBStrain00007559
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog (33)
    Paralog: WBGene00001484 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00011279 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: spn-4 encodes a protein containing an RNP-type RNA-binding domain; SPN-4 is required for rotation, but not polarization, of the mitotic spindle in the P1 blastomere of the two-cell stage embryo; SPN-4 is also required for mesectoderm and mesendoderm formation in conjunction with proper localization of maternal cell-fate determinants such as SKN-1; in addition, SPN-4 binds the glp-1 3' UTR and is necessary for glp-1 mRNA translation in the anterior blastomeres of the early embryo; conversely, SPN-4 binds and suppresses translation of pal-1 and skn-1 mRNAs in anterior blastomeres; in vitro, SPN-4 interacts with POS-1, a CCCH-type zinc finger protein that negatively regulates glp-1 mRNA translation in posterior blastomeres; SPN-4 is a P granule component, but is also detected in oocytes, the AB and P1 blastomeres at the two-cell stage, and in all four blastomeres at the four-cell stage, with higher levels in EMS and P2. Paper_evidence: WBPaper00004995
            WBPaper00005160
            WBPaper00005882
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable mRNA binding activity. Predicted to be involved in nervous system development and regulation of alternative mRNA splicing, via spliceosome. Located in P granule. Expressed in several structures, including Psub4; Z2; Z3; germ line; and oocyte. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: ZC404.8
    Corresponding_transcript: ZC404.8.1
    Other_sequence (17)
    Associated_feature: WBsf669075
      WBsf977443
      WBsf977444
      WBsf977445
      WBsf977446
      WBsf977447
      WBsf977448
      WBsf233866
      WBsf233867
    Gene_product_binds: WBsf034245
    Transcription_factor: WBTranscriptionFactor000118
  Experimental_info: RNAi_result (53)
    Expr_pattern (11)
    Drives_construct: WBCnstr00005291
      WBCnstr00020312
      WBCnstr00035293
      WBCnstr00042915
    Construct_product: WBCnstr00005245
      WBCnstr00021256
      WBCnstr00035293
    Regulate_expr_cluster: WBPaper00058598:spn-4(tm291)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
    Antibody: WBAntibody00000616
      WBAntibody00000904
      WBAntibody00001404
    Microarray_results (19)
    Expression_cluster (241)
    Interaction: WBInteraction000001618
      WBInteraction000002071
      WBInteraction000002138
      WBInteraction000002648
      WBInteraction000003471
      WBInteraction000003541
      WBInteraction000003570
      WBInteraction000003702
      WBInteraction000003970
      WBInteraction000006442
      WBInteraction000006788
      WBInteraction000007346
      WBInteraction000007556
      WBInteraction000008084
      WBInteraction000008096
      WBInteraction000008105
      WBInteraction000008119
      WBInteraction000008128
      WBInteraction000008148
      WBInteraction000008155
      WBInteraction000008162
      WBInteraction000008211
      WBInteraction000008237
      WBInteraction000009035
      WBInteraction000009596
      WBInteraction000009597
      WBInteraction000009726
      WBInteraction000009728
      WBInteraction000009729
      WBInteraction000009730
      WBInteraction000009731
      WBInteraction000029134
      WBInteraction000051826
      WBInteraction000104608
      WBInteraction000105426
      WBInteraction000106195
      WBInteraction000110409
      WBInteraction000111075
      WBInteraction000111823
      WBInteraction000111942
      WBInteraction000112663
      WBInteraction000114552
      WBInteraction000114980
      WBInteraction000115190
      WBInteraction000117724
      WBInteraction000118052
      WBInteraction000119358
      WBInteraction000119781
      WBInteraction000119938
      WBInteraction000119985
      WBInteraction000120300
      WBInteraction000120859
      WBInteraction000125839
      WBInteraction000125905
      WBInteraction000133090
      WBInteraction000133341
      WBInteraction000134287
      WBInteraction000134819
      WBInteraction000135456
      WBInteraction000136166
      WBInteraction000138565
      WBInteraction000141539
      WBInteraction000141899
      WBInteraction000143630
      WBInteraction000143994
      WBInteraction000145109
      WBInteraction000146992
      WBInteraction000147407
      WBInteraction000147890
      WBInteraction000149581
      WBInteraction000149748
      WBInteraction000152642
      WBInteraction000153006
      WBInteraction000153036
      WBInteraction000160935
      WBInteraction000163415
      WBInteraction000164136
      WBInteraction000165784
      WBInteraction000165832
      WBInteraction000166101
      WBInteraction000166168
      WBInteraction000166170
      WBInteraction000166243
      WBInteraction000166545
      WBInteraction000166577
      WBInteraction000170186
      WBInteraction000171878
      WBInteraction000172718
      WBInteraction000175269
      WBInteraction000175599
      WBInteraction000176026
      WBInteraction000176479
      WBInteraction000176852
      WBInteraction000177142
      WBInteraction000177729
      WBInteraction000177768
      WBInteraction000178974
      WBInteraction000180417
      WBInteraction000181123
      WBInteraction000181291
      WBInteraction000181380
      WBInteraction000181844
      WBInteraction000182781
      WBInteraction000184081
      WBInteraction000184132
      WBInteraction000186846
      WBInteraction000187167
      WBInteraction000187462
      WBInteraction000188171
      WBInteraction000188404
      WBInteraction000188480
      WBInteraction000190933
      WBInteraction000191764
      WBInteraction000192230
      WBInteraction000192940
      WBInteraction000193712
      WBInteraction000194072
      WBInteraction000194298
      WBInteraction000194956
      WBInteraction000195242
      WBInteraction000195404
      WBInteraction000196906
      WBInteraction000197540
      WBInteraction000197801
      WBInteraction000198146
      WBInteraction000200037
      WBInteraction000201550
      WBInteraction000201695
      WBInteraction000202672
      WBInteraction000203633
      WBInteraction000206119
      WBInteraction000207941
      WBInteraction000211638
      WBInteraction000214176
      WBInteraction000214372
      WBInteraction000215710
      WBInteraction000218880
      WBInteraction000218995
      WBInteraction000220373
      WBInteraction000220600
      WBInteraction000220774
      WBInteraction000221198
      WBInteraction000221871
      WBInteraction000223923
      WBInteraction000225596
      WBInteraction000230878
      WBInteraction000231356
      WBInteraction000233334
      WBInteraction000234857
      WBInteraction000235139
      WBInteraction000236543
      WBInteraction000238327
      WBInteraction000239031
      WBInteraction000239591
      WBInteraction000240153
      WBInteraction000241416
      WBInteraction000242849
      WBInteraction000243080
      WBInteraction000254941
      WBInteraction000255250
      WBInteraction000255427
      WBInteraction000256290
      WBInteraction000256912
      WBInteraction000257700
      WBInteraction000257708
      WBInteraction000258553
      WBInteraction000259984
      WBInteraction000260228
      WBInteraction000263647
      WBInteraction000263795
      WBInteraction000267285
      WBInteraction000273106
      WBInteraction000273304
      WBInteraction000277775
      WBInteraction000278610
      WBInteraction000280470
      WBInteraction000281255
      WBInteraction000281961
      WBInteraction000282104
      WBInteraction000282226
      WBInteraction000282848
      WBInteraction000285596
      WBInteraction000286559
      WBInteraction000286695
      WBInteraction000287018
      WBInteraction000289501
      WBInteraction000293581
      WBInteraction000294110
      WBInteraction000295846
      WBInteraction000297110
      WBInteraction000297155
      WBInteraction000301006
      WBInteraction000302317
      WBInteraction000303175
      WBInteraction000303729
      WBInteraction000304269
      WBInteraction000304393
      WBInteraction000305540
      WBInteraction000306355
      WBInteraction000308538
      WBInteraction000313729
      WBInteraction000314415
      WBInteraction000315092
      WBInteraction000316626
      WBInteraction000317782
      WBInteraction000318400
      WBInteraction000319519
      WBInteraction000323831
      WBInteraction000324168
      WBInteraction000329973
      WBInteraction000330969
      WBInteraction000338199
      WBInteraction000339354
      WBInteraction000341513
      WBInteraction000342221
      WBInteraction000342611
      WBInteraction000349426
      WBInteraction000349526
      WBInteraction000351368
      WBInteraction000352336
      WBInteraction000353741
      WBInteraction000354043
      WBInteraction000354861
      WBInteraction000355695
      WBInteraction000358310
      WBInteraction000363512
      WBInteraction000364348
      WBInteraction000365534
      WBInteraction000367715
      WBInteraction000368349
      WBInteraction000370278
      WBInteraction000372830
      WBInteraction000375786
      WBInteraction000376456
      WBInteraction000379278
      WBInteraction000380453
      WBInteraction000381503
      WBInteraction000382501
      WBInteraction000382941
      WBInteraction000389536
      WBInteraction000391178
      WBInteraction000392552
      WBInteraction000395604
      WBInteraction000395792
      WBInteraction000399115
      WBInteraction000399280
      WBInteraction000400108
      WBInteraction000402700
      WBInteraction000402967
      WBInteraction000404778
      WBInteraction000406199
      WBInteraction000406415
      WBInteraction000408353
      WBInteraction000419329
      WBInteraction000420057
      WBInteraction000422149
      WBInteraction000422207
      WBInteraction000425790
      WBInteraction000426773
      WBInteraction000427593
      WBInteraction000427944
      WBInteraction000428626
      WBInteraction000431762
      WBInteraction000432220
      WBInteraction000434331
      WBInteraction000434950
      WBInteraction000435168
      WBInteraction000435761
      WBInteraction000435859
      WBInteraction000437351
      WBInteraction000446049
      WBInteraction000448675
      WBInteraction000457376
      WBInteraction000460388
      WBInteraction000501417
      WBInteraction000501771
      WBInteraction000501775
      WBInteraction000501863
      WBInteraction000503591
      WBInteraction000517469
      WBInteraction000518573
      WBInteraction000518574
      WBInteraction000520748
      WBInteraction000523066
      WBInteraction000524492
      WBInteraction000538895
      WBInteraction000540565
      WBInteraction000541081
      WBInteraction000549255
      WBInteraction000550331
      WBInteraction000550407
      WBInteraction000550434
      WBInteraction000550437
      WBInteraction000550486
      WBInteraction000550491
      WBInteraction000550495
      WBInteraction000550498
      WBInteraction000550500
      WBInteraction000550502
      WBInteraction000550507
      WBInteraction000550613
      WBInteraction000550616
      WBInteraction000550620
      WBInteraction000550625
      WBInteraction000550627
      WBInteraction000550629
      WBInteraction000550666
      WBInteraction000554917
      WBInteraction000554920
      WBInteraction000556365
      WBInteraction000559707
      WBInteraction000573586
      WBInteraction000574456
      WBInteraction000575262
      WBInteraction000578281
      WBInteraction000579359
      WBInteraction000582633
    WBProcess: WBbiopr:00000017
  Map_info: Map: V Position: 0.165431 Error: 0.017895
    Well_ordered
    Positive: Positive_clone: T11B11
        ZC404 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Negative_clone: ZC461
    Mapping_data: Multi_point: 4024
        4690
        4923
  Reference (54)
  Remark: recent data from gomes@molbio.uoregon.edu
    Sequence connection from [Qadota H, Kaibuchi K]
  Method: Gene