WormBase Tree Display for Gene: WBGene00004951
expand all nodes | collapse all nodes | view schema
| WBGene00004951 | SMap | S_parent | Sequence | K10B3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | spc-1 | Person_evidence | WBPerson427 | |||||
| Sequence_name | K10B3.10 | ||||||||
| Molecular_name (6) | |||||||||
| Other_name | imo-1 | ||||||||
| CELE_K10B3.10 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | spc-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | spc | ||||||||
| Allele (142) | |||||||||
| Possibly_affected_by | WBVar02152908 | ||||||||
| Legacy_information | [Norman KR] imo for incomplete morphogenesis. imo-1 (ra409) homozygotes are L1 lethals due to a defect in embryonic elongation. | ||||||||
| re-named to spc-1 for spectrin [sdm/jah] | |||||||||
| Complementation_data | [Norman KR] complements dpy-3 (e27), dpy-7 (sc27), lon-2 (e678), unc-2 (e55), unc- 20 (e112), unc-78 (e1217) | ||||||||
| Strain | WBStrain00005882 | ||||||||
| WBStrain00034760 | |||||||||
| WBStrain00047279 | |||||||||
| WBStrain00047277 | |||||||||
| WBStrain00047274 | |||||||||
| WBStrain00047278 | |||||||||
| RNASeq_FPKM (73) | |||||||||
| GO_annotation (17) | |||||||||
| Ortholog (37) | |||||||||
| Paralog (13) | |||||||||
| Structured_description | Concise_description | spc-1 encodes the C. elegans alpha spectrin ortholog; during development, spc-1 activity is required for body morphogenesis, formation of body wall muscles, locomotion, and larval development. | Paper_evidence | WBPaper00004127 | |||||
| WBPaper00005321 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 31 Jan 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable actin filament binding activity. Involved in several processes, including embryonic body morphogenesis; nematode larval development; and regulation of growth. Predicted to be located in several cellular components, including cell junction; cortical actin cytoskeleton; and plasma membrane. Expressed in several structures, including body wall musculature; hermaphrodite gonad; intestine; pharynx; and vulval cell. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 5 and hereditary spherocytosis type 3. Is an ortholog of human SPTAN1 (spectrin alpha, non-erythrocytic 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | EFO:MONDO:0015362 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11273) | ||||
| DOID:0080438 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11273) | ||||||
| DOID:0110918 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11272) | ||||||
| DOID:12971 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11272) | ||||||
| Molecular_info | Corresponding_CDS | K10B3.10a | |||||||
| K10B3.10b | |||||||||
| Corresponding_transcript | K10B3.10a.1 | ||||||||
| K10B3.10b.1 | |||||||||
| Other_sequence (138) | |||||||||
| Associated_feature (24) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00060090 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00060091 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00060092 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00025934 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00050477 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00000485 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00080495 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00008979 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00022774 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00060093 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00035308 | ||||||||
| WBCnstr00041562 | |||||||||
| Construct_product | WBCnstr00035308 | ||||||||
| WBCnstr00041562 | |||||||||
| Regulate_expr_cluster | WBPaper00057041:spc-1(cas971)_downregulated | ||||||||
| WBPaper00057041:spc-1(cas971)_upregulated | |||||||||
| Antibody | WBAntibody00000528 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (216) | |||||||||
| Interaction (480) | |||||||||
| WBProcess | WBbiopr:00000006 | ||||||||
| Map_info | Map | X | Position | -12.1435 | Error | 0.053657 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | mnDp33 | |||||||
| Positive_clone | K10B3 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| M01F12 | |||||||||
| Mapping_data | Multi_point | 3805 | |||||||
| 3806 | |||||||||
| 5603 | |||||||||
| Pos_neg_data | 10240 | ||||||||
| Reference (35) | |||||||||
| Method | Gene |
