WormBase Tree Display for Gene: WBGene00004889

WBGene00004889 SMap: S_parent: Sequence: Y54E5B
  Identity: Version: 1
    Name: CGC_name: smp-1 Person_evidence: WBPerson893
      Sequence_name: Y54E5B.1
      Molecular_name (12)
      Other_name: cesema Accession_evidence: EMBL U15667
        CELE_Y54E5B.1 Accession_evidence: NDB BX284601
      Public_name: smp-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: smp
    Allele (144)
    Strain: WBStrain00029151
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog: WBGene00060899 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00038880 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00155282 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00098145 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00120646 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00190473 Caenorhabditis brenneri From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00231007 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g12360 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g6975 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g5865 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g8256 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g13375 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g12274 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g9270 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g13417 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g26334 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g9210 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g9433 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00009.g734 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-smp-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold572.g4304 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_05592.g35262 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_21220 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_001443 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g05993 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g5977 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_10001500 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrI_pilon.g2971 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00238419 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00261789 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00285301 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0011259 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0016059 Drosophila melanogaster From_analysis: Hieranoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-990715-2 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            Panther
      ZFIN:ZDB-GENE-990715-8 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            Panther
      ZFIN:ZDB-GENE-991209-3 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            Panther
      ZFIN:ZDB-GENE-991209-6 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            Panther
      ZFIN:ZDB-GENE-040426-1933 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-050513-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            Panther
      ZFIN:ZDB-GENE-050513-3 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            Panther
      ZFIN:ZDB-GENE-050513-4 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            Panther
      ZFIN:ZDB-GENE-050417-171 Danio rerio From_analysis: OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-050513-5 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            Panther
      ZFIN:ZDB-GENE-040724-119 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-050208-762 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            Panther
      ZFIN:ZDB-GENE-120503-1 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
      ZFIN:ZDB-GENE-080303-16 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
      ZFIN:ZDB-GENE-131024-1 Danio rerio From_analysis: OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030131-5796 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            Panther
      ZFIN:ZDB-GENE-060503-381 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
      ZFIN:ZDB-GENE-030131-7864 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            Panther
      ZFIN:ZDB-GENE-081105-78 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            Panther
      ZFIN:ZDB-GENE-070705-31 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
      ZFIN:ZDB-GENE-050513-2 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            Panther
      ZFIN:ZDB-GENE-030131-2956 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            Panther
      ZFIN:ZDB-GENE-081105-129 Danio rerio From_analysis: OMA
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:10728 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Panther
      HGNC:10724 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            OMA
            OrthoInspector
            Panther
      HGNC:10727 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoInspector
            Panther
      HGNC:10723 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoInspector
            Panther
      HGNC:10740 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:10739 Homo sapiens From_analysis: Inparanoid
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:10734 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
            OrthoInspector
            Panther
      HGNC:10732 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
      HGNC:10730 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
      HGNC:10725 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            OMA
            OrthoInspector
            Panther
      HGNC:10731 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
      HGNC:30400 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoInspector
            Panther
      HGNC:10738 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:10735 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
      HGNC:16770 Homo sapiens From_analysis: Inparanoid
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:10726 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoInspector
            Panther
      MGI:107558 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            OMA
            OrthoInspector
            Panther
      MGI:107561 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            OMA
            OrthoInspector
            Panther
      MGI:107557 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            OMA
            OrthoInspector
            Panther
      MGI:1340034 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoInspector
            Panther
      MGI:1096347 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Panther
      MGI:107559 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
      MGI:109252 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
      MGI:109244 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
      MGI:1340055 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1203727 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1202889 Mus musculus From_analysis: Inparanoid
            Panther
            SonicParanoid
      MGI:1338032 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1347047 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoInspector
            Panther
      MGI:1860118 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoInspector
            Panther
      MGI:2387661 Mus musculus From_analysis: Inparanoid
            Panther
            SonicParanoid
      MGI:3041242 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoInspector
            Panther
      RGD:3659 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Panther
            PhylomeDB
      RGD:3658 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      RGD:3657 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      RGD:727939 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoInspector
            Panther
      RGD:1306079 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoInspector
            Panther
      RGD:1307872 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1309343 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoInspector
            Panther
      RGD:1310973 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoInspector
            Panther
      RGD:1562837 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1310554 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1304636 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            SonicParanoid
      RGD:1308514 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Panther
      RGD:1310436 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1310079 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            OMA
            OrthoInspector
            Panther
    Paralog: WBGene00003111 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00004890 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009094 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: smp-1 encodes a semaphorin; smp-1 activity is required for vulval morphogenesis, specifically for the movement of homologous pairs of vulval cells towards the vulval midline prior to cell fusion; smp-1 expression in vulval cells is regulated by the VAB-23 zinc-finger domain protein which binds smp-1 regulatory sequence in vivo. Paper_evidence: WBPaper00040292
            WBPaper00025151
          Curator_confirmed: WBPerson1843
          Date_last_updated: 13 Oct 2011 00:00:00
      Automated_description: Enables semaphorin receptor binding activity. Involved in nematode male tail mating organ morphogenesis. Predicted to be located in membrane. Expressed in several structures, including hermaphrodite distal tip cell; non-striated muscle; ray; somatic nervous system; and vulval cell. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 16 with or without anosmia; progressive myoclonus epilepsy; and rheumatoid arthritis. Is an ortholog of several human genes including SEMA3B (semaphorin 3B); SEMA3C (semaphorin 3C); and SEMA6C (semaphorin 6C). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:7148 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10725)
      DOID:0090080 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10723)
      DOID:891 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10739)
  Molecular_info: Corresponding_CDS: Y54E5B.1a
      Y54E5B.1b
      Y54E5B.1c
    Corresponding_transcript: Y54E5B.1a.1
      Y54E5B.1b.1
      Y54E5B.1b.2
      Y54E5B.1b.3
      Y54E5B.1b.4
      Y54E5B.1c.1
    Other_sequence (24)
    Associated_feature (24)
  Experimental_info: RNAi_result: WBRNAi00065917 Inferred_automatically: RNAi_primary
      WBRNAi00022980 Inferred_automatically: RNAi_primary
      WBRNAi00022981 Inferred_automatically: RNAi_primary
      WBRNAi00116872 Inferred_automatically: RNAi_primary
      WBRNAi00057388 Inferred_automatically: RNAi_primary
      WBRNAi00004745 Inferred_automatically: RNAi_primary
      WBRNAi00091930 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1885
      Expr3276
      Expr9188
      Expr1026364
      Expr1032428
      Expr1160822
      Expr2015922
      Expr2034155
    Drives_construct (15)
    Construct_product (20)
    Microarray_results (27)
    Expression_cluster (129)
    Interaction (45)
    Anatomy_function: WBbtf0686
      WBbtf0687
      WBbtf0688
      WBbtf0689
      WBbtf0690
      WBbtf0691
      WBbtf1066
  Map_info: Map: I Position: 27.3982 Error: 0.247471
    Positive: Positive_clone: Y54E5B Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4669
    Pseudo_map_position
  Reference (35)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene