WormBase Tree Display for Gene: WBGene00004876
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| WBGene00004876 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | K11G12 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | smf-1 | Person_evidence | WBPerson168 | |||||
| Sequence_name | K11G12.4 | ||||||||
| Molecular_name | K11G12.4a | ||||||||
| K11G12.4a.1 | |||||||||
| CE41828 | |||||||||
| K11G12.4b | |||||||||
| Other_name | CELE_K11G12.4 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | smf-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | smf | ||||||||
| Allele (54) | |||||||||
| Strain | WBStrain00032188 | ||||||||
| WBStrain00021956 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (27) | |||||||||
| Contained_in_operon | CEOPX080 | ||||||||
| Ortholog (33) | |||||||||
| Paralog | WBGene00004877 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004878 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | smf-1 encodes one of three C. elegans divalent-metal ion transporters (DMTs) orthologous to the mammalian DMT1 transporters and Saccharomyces cerevisiae Smf proteins; in C. elegans, SMF-1 plays a minor role in manganese uptake, although mutations in smf-1 do display an increased tolerance to manganese exposure; SMF-1 is broadly expressed fromlate embryogenesis through adulthood, with strongest expression seen in the intestine and its associated gland cells; in epithelia, SMF-1 displays partially overlapping localization at the apical plasma membrane with SMF-3; smf-1 transcription is regulated in response to manganese; when expressed in Saccharomyces cerevisiae, smf-1 can rescue the EGTA hypersensitivity of Smf1+2 mutants. | Paper_evidence | WBPaper00035485 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 04 Aug 2010 00:00:00 | ||||||||
| Automated_description | Predicted to enable cadmium ion transmembrane transporter activity; iron ion transmembrane transporter activity; and manganese ion transmembrane transporter activity. Involved in monoatomic cation homeostasis; negative regulation of cellular response to manganese ion; and response to manganese ion. Located in apical plasma membrane. Expressed in several structures, including excretory cell; hermaphrodite gonad; intestine; nerve ring; and neurons. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); leishmaniasis (multiple); and neurodegenerative disease (multiple). Is an ortholog of human SLC11A1 (solute carrier family 11 member 1) and SLC11A2 (solute carrier family 11 member 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (25) | ||||||||
| Molecular_info | Corresponding_CDS | K11G12.4a | |||||||
| Corresponding_CDS_history | K11G12.4:wp129 | ||||||||
| K11G12.4a:wp184 | |||||||||
| K11G12.4b:wp248 | |||||||||
| Corresponding_transcript | K11G12.4b | ||||||||
| K11G12.4a.1 | |||||||||
| Other_sequence (32) | |||||||||
| Associated_feature | WBsf237512 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00017020 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00050614 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00108000 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00082085 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00108005 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00050613 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00082079 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076571 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00082080 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00082083 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr8811 | ||||||||
| Expr8859 | |||||||||
| Expr12160 | |||||||||
| Expr1015427 | |||||||||
| Expr1032417 | |||||||||
| Expr1154320 | |||||||||
| Expr2015904 | |||||||||
| Expr2034137 | |||||||||
| Drives_construct | WBCnstr00013568 | ||||||||
| WBCnstr00019898 | |||||||||
| WBCnstr00020298 | |||||||||
| WBCnstr00035346 | |||||||||
| Construct_product | WBCnstr00013568 | ||||||||
| WBCnstr00013569 | |||||||||
| WBCnstr00019900 | |||||||||
| WBCnstr00035346 | |||||||||
| Antibody | WBAntibody00001996 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (93) | |||||||||
| Interaction (35) | |||||||||
| WBProcess | WBbiopr:00000096 | ||||||||
| Map_info | Map | X | Position | -2.5294 | Error | 0.00832 | |||
| Positive | Positive_clone | K11G12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4665 | |||||||
| 4666 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (18) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
