WormBase Tree Display for Gene: WBGene00004831
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| WBGene00004831 | SMap | S_parent | Sequence | F08B12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | slo-2 | Person_evidence | WBPerson689 | |||||
| Sequence_name | F08B12.3 | ||||||||
| Molecular_name (24) | |||||||||
| Other_name | CELE_F08B12.3 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | slo-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 13 Feb 2012 10:16:05 | WBPerson1983 | Event | Acquires_merge | WBGene00008573 | ||||
| Acquires_merge | WBGene00008573 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | slo | ||||||||
| Allele (167) | |||||||||
| Strain | WBStrain00001498 | ||||||||
| WBStrain00026422 | |||||||||
| WBStrain00026423 | |||||||||
| WBStrain00036900 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (42) | |||||||||
| Paralog | WBGene00004830 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | slo-2 encodes a high conductance, sodium-activated potassium channel; when expressed in Xenopus oocytes, SLO-2 exhibits a synergistic dependence on both chloride and calcium ions for activation; expression of a dominant negative SLO-2 mutant can interfere with activity of SLO-1, a second high conductance potassium channel, suggesting that the two channels can form functional heteromultimers; a SLO-2::GFP fusion protein is expressed in body wall, vulval, and pharyngeal/intestinal valve muscles, nerve ring processes, and some motor neurons in the ventral nerve cord; SLO-2 expression largely overlaps with that of SLO-1. | Paper_evidence | WBPaper00004344 | |||||
| WBPaper00006234 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 28 Oct 2008 00:00:00 | ||||||||
| Automated_description | Enables calcium-activated potassium channel activity and outward rectifier potassium channel activity. Involved in positive regulation of neurotransmitter secretion and potassium ion transport. Located in axon. Expressed in amphid neurons; body wall musculature; motor neurons; nerve ring; and vulval muscle. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 5; developmental and epileptic encephalopathy 14; and developmental and epileptic encephalopathy 57. Is an ortholog of human KCNT1 (potassium sodium-activated channel subfamily T member 1) and KCNT2 (potassium sodium-activated channel subfamily T member 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060686 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18865) | ||||
| DOID:0080284 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18866) | ||||||
| DOID:0080439 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18865) | ||||||
| Molecular_info | Corresponding_CDS | F08B12.3a | |||||||
| F08B12.3b | |||||||||
| F08B12.3c | |||||||||
| F08B12.3d | |||||||||
| F08B12.3e | |||||||||
| F08B12.3f | |||||||||
| F08B12.3g | |||||||||
| F08B12.3h | |||||||||
| Corresponding_transcript | F08B12.3a.1 | ||||||||
| F08B12.3b.1 | |||||||||
| F08B12.3c.1 | |||||||||
| F08B12.3d.1 | |||||||||
| F08B12.3e.1 | |||||||||
| F08B12.3f.1 | |||||||||
| F08B12.3g.1 | |||||||||
| F08B12.3h.1 | |||||||||
| Other_sequence (17) | |||||||||
| Associated_feature | WBsf654411 | ||||||||
| WBsf654412 | |||||||||
| WBsf654413 | |||||||||
| WBsf671028 | |||||||||
| WBsf1006991 | |||||||||
| WBsf237959 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00000745 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00022321 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00043963 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (14) | |||||||||
| Drives_construct | WBCnstr00002355 | ||||||||
| WBCnstr00010079 | |||||||||
| WBCnstr00012420 | |||||||||
| WBCnstr00013012 | |||||||||
| WBCnstr00035357 | |||||||||
| WBCnstr00040464 | |||||||||
| Construct_product | WBCnstr00010079 | ||||||||
| WBCnstr00012420 | |||||||||
| WBCnstr00022474 | |||||||||
| WBCnstr00022476 | |||||||||
| WBCnstr00035357 | |||||||||
| WBCnstr00040464 | |||||||||
| Antibody | WBAntibody00000254 | ||||||||
| Microarray_results (50) | |||||||||
| Expression_cluster (185) | |||||||||
| Interaction | WBInteraction000147216 | ||||||||
| WBInteraction000366977 | |||||||||
| WBInteraction000561588 | |||||||||
| WBInteraction000567112 | |||||||||
| WBInteraction000567113 | |||||||||
| WBInteraction000567114 | |||||||||
| Map_info | Map | X | Position | 3.51722 | Error | 0.06473 | |||
| Positive | Positive_clone | F08B12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4569 | |||||||
| 4663 | |||||||||
| 5493 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (34) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
