WormBase Tree Display for Gene: WBGene00004831
expand all nodes | collapse all nodes | view schema
WBGene00004831 | SMap | S_parent | Sequence | F08B12 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | slo | ||||||
Allele (167) | |||||||
Strain | WBStrain00001498 | ||||||
WBStrain00026422 | |||||||
WBStrain00026423 | |||||||
WBStrain00036900 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (15) | |||||||
Ortholog (42) | |||||||
Paralog | WBGene00004830 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Panther | |||||||
WormBase-Compara | |||||||
Structured_description | Concise_description | slo-2 encodes a high conductance, sodium-activated potassium channel; when expressed in Xenopus oocytes, SLO-2 exhibits a synergistic dependence on both chloride and calcium ions for activation; expression of a dominant negative SLO-2 mutant can interfere with activity of SLO-1, a second high conductance potassium channel, suggesting that the two channels can form functional heteromultimers; a SLO-2::GFP fusion protein is expressed in body wall, vulval, and pharyngeal/intestinal valve muscles, nerve ring processes, and some motor neurons in the ventral nerve cord; SLO-2 expression largely overlaps with that of SLO-1. | Paper_evidence | WBPaper00004344 | |||
WBPaper00006234 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 28 Oct 2008 00:00:00 | ||||||
Automated_description | Enables calcium-activated potassium channel activity and outward rectifier potassium channel activity. Involved in positive regulation of neurotransmitter secretion and potassium ion transport. Located in axon. Expressed in amphid neurons; body wall musculature; motor neurons; nerve ring; and vulval muscle. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 5; developmental and epileptic encephalopathy 14; and developmental and epileptic encephalopathy 57. Is an ortholog of human KCNT1 (potassium sodium-activated channel subfamily T member 1) and KCNT2 (potassium sodium-activated channel subfamily T member 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0060686 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18865) | ||
DOID:0080284 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18866) | ||||
DOID:0080439 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18865) | ||||
Molecular_info | Corresponding_CDS | F08B12.3a | |||||
F08B12.3b | |||||||
F08B12.3c | |||||||
F08B12.3d | |||||||
F08B12.3e | |||||||
F08B12.3f | |||||||
F08B12.3g | |||||||
F08B12.3h | |||||||
Corresponding_transcript | F08B12.3a.1 | ||||||
F08B12.3b.1 | |||||||
F08B12.3c.1 | |||||||
F08B12.3d.1 | |||||||
F08B12.3e.1 | |||||||
F08B12.3f.1 | |||||||
F08B12.3g.1 | |||||||
F08B12.3h.1 | |||||||
Other_sequence (17) | |||||||
Associated_feature | WBsf654411 | ||||||
WBsf654412 | |||||||
WBsf654413 | |||||||
WBsf671028 | |||||||
WBsf1006991 | |||||||
WBsf237959 | |||||||
Experimental_info | RNAi_result | WBRNAi00000745 | Inferred_automatically | RNAi_primary | |||
WBRNAi00022321 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00043963 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (14) | |||||||
Drives_construct | WBCnstr00002355 | ||||||
WBCnstr00010079 | |||||||
WBCnstr00012420 | |||||||
WBCnstr00013012 | |||||||
WBCnstr00035357 | |||||||
WBCnstr00040464 | |||||||
Construct_product | WBCnstr00010079 | ||||||
WBCnstr00012420 | |||||||
WBCnstr00022474 | |||||||
WBCnstr00022476 | |||||||
WBCnstr00035357 | |||||||
WBCnstr00040464 | |||||||
Antibody | WBAntibody00000254 | ||||||
Microarray_results (50) | |||||||
Expression_cluster (185) | |||||||
Interaction | WBInteraction000147216 | ||||||
WBInteraction000366977 | |||||||
WBInteraction000561588 | |||||||
WBInteraction000567112 | |||||||
WBInteraction000567113 | |||||||
WBInteraction000567114 | |||||||
Map_info | Map | X | Position | 3.51722 | Error | 0.06473 | |
Positive | Positive_clone | F08B12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4569 | |||||
4663 | |||||||
5493 | |||||||
Pseudo_map_position | |||||||
Reference (34) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |