skp-1 encodes the C. elegans ortholog of the SKI-binding protein (SKIP); skp-1 is predicted to function as a transcriptional cofactor and its activity is essential for embryogenesis and molting; skp-1 is also required for normal expression of several embryonic genes, as assayed by gfp reporter fusions; SKP-1 is widely expressed from embryogenesis through adulthood.
Involved in several processes, including molting cycle; reproductive process; and vulval development. Predicted to be part of spliceosomal complex. Expressed in egg-laying apparatus; hypodermis; pharynx; rectal muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in breast carcinoma; hepatocellular carcinoma; and pancreatic cancer. Is an ortholog of human SNW1 (SNW domain containing 1).
Gene name created based on Pubmed 12084813 [krb 020719]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.