WormBase Tree Display for Gene: WBGene00004800

WBGene00004800 SMap: S_parent: Sequence: R11A8
  Identity: Version: 1
    Name: CGC_name: sir-2.1 Person_evidence: WBPerson1840
      Sequence_name: R11A8.4
      Molecular_name: R11A8.4a
        R11A8.4a.1
        CE06302
        R11A8.4b
        CE44629
        R11A8.4b.1
      Other_name: CELE_R11A8.4 Accession_evidence: NDB BX284604
      Public_name: sir-2.1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sir
    Allele (42)
    Strain (5)
    RNASeq_FPKM (74)
    GO_annotation (36)
    Contained_in_operon: CEOP4372
    Ortholog: WBGene00059218 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00042025 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00145802 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00152999 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00120095 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00108481 Pristionchus pacificus From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00220679 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g8537 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g6138 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g14917 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP26.g18107 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g21700 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g7387 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g17066 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g10531 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g15176 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g9513 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g15086 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00070.g3359 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-sir-2.1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g17780 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00358.g10059 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_22990 Caenorhabditis latens From_analysis: WormBase-Compara
      FL83_22992 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_014969 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g07856 Oscheius tipulae From_analysis: WormBase-Compara
      Sp34_40086500 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIV_pilon.g11579 Caenorhabditis elegans From_analysis: WormBase-Compara
      chrIV_pilon.g12097 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00059212 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00073464 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00241501 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00287625 Trichuris muris From_analysis: WormBase-Compara
      WBGene00296012 Trichuris muris From_analysis: WormBase-Compara
      WBGene00299967 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000002200 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      SGD:S000005429 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0024291 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-070801-2 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:14929 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:2135607 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1308542 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00014769 Caenorhabditis elegans From_analysis: modENCODE_Pseudogenes
      WBGene00004801 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004802 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004803 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: sir-2.1 encodes an NAD-dependent protein deacetylase with similarity to Saccharomyces cerevisiae Sir2p and mammalian SIRT1. Paper_evidence: WBPaper00004566
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 14 Nov 2014 00:00:00
      Automated_description: Enables deacetylase activity. Involved in dauer larval development; determination of adult lifespan; and intrinsic apoptotic signaling pathway in response to DNA damage. Located in chromosome, telomeric region; nucleus; and perinuclear region of cytoplasm. Expressed in several structures, including intestinal cell; neurons; retrovesicular ganglion; tail; and ventral nerve cord. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; non-alcoholic fatty liver disease; and senile cataract. Is an ortholog of human SIRT1 (sirtuin 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:1574 Homo sapiens Paper_evidence: WBPaper00041098
          Curator_confirmed: WBPerson324
          Date_last_updated: 21 May 2019 00:00:00
    Potential_model: DOID:9669 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14929)
      DOID:12858 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14929)
      DOID:10283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14929)
      DOID:4448 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14929)
      DOID:0080208 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14929)
      DOID:1826 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14929)
  Models_disease_asserted: WBDOannot00000675
  Molecular_info: Corresponding_CDS: R11A8.4a
      R11A8.4b
    Corresponding_transcript: R11A8.4a.1
      R11A8.4b.1
    Other_sequence (27)
    Associated_feature: WBsf652127
      WBsf230722
      WBsf230723
      WBsf230724
  Experimental_info: RNAi_result (22)
    Expr_pattern (11)
    Drives_construct (18)
    Construct_product (18)
    Regulate_expr_cluster (22)
    Antibody: WBAntibody00001101
      WBAntibody00001123
      WBAntibody00001697
      WBAntibody00001698
    Microarray_results (26)
    Expression_cluster (97)
    Interaction (156)
    WBProcess: WBbiopr:00000001
      WBbiopr:00000121
  Map_info: Map: IV Position: 4.57839 Error: 0.000393
    Positive: Positive_clone: R11A8 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4660
    Pseudo_map_position
  Reference (245)
  Remark: Sequence connection from [Tissenbaum HA]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene