WormBase Tree Display for Gene: WBGene00004800
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WBGene00004800 | SMap | S_parent | Sequence | R11A8 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | sir | ||||||
Allele (42) | |||||||
Strain | WBStrain00024177 | ||||||
WBStrain00022167 | |||||||
WBStrain00026544 | |||||||
WBStrain00035578 | |||||||
WBStrain00047283 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (36) | |||||||
Contained_in_operon | CEOP4372 | ||||||
Ortholog (42) | |||||||
Paralog | WBGene00014769 | Caenorhabditis elegans | From_analysis | modENCODE_Pseudogenes | |||
WBGene00004801 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00004802 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00004803 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | sir-2.1 encodes an NAD-dependent protein deacetylase with similarity to Saccharomyces cerevisiae Sir2p and mammalian SIRT1. | Paper_evidence | WBPaper00004566 | |||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 14 Nov 2014 00:00:00 | ||||||
Automated_description | Enables deacetylase activity. Involved in dauer larval development; determination of adult lifespan; and intrinsic apoptotic signaling pathway in response to DNA damage. Located in chromosome, telomeric region; nucleus; and perinuclear region of cytoplasm. Expressed in several structures, including intestinal cell; neurons; retrovesicular ganglion; tail; and ventral nerve cord. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; non-alcoholic fatty liver disease; and senile cataract. Is an ortholog of human SIRT1 (sirtuin 1). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00041098 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 21 May 2019 00:00:00 | ||||||
Potential_model | DOID:9669 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14929) | |||
DOID:12858 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14929) | ||||
DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14929) | ||||
DOID:4448 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14929) | ||||
DOID:0080208 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14929) | ||||
DOID:1826 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14929) | ||||
Models_disease_asserted | WBDOannot00000675 | ||||||
Molecular_info | Corresponding_CDS | R11A8.4a | |||||
R11A8.4b | |||||||
Corresponding_transcript | R11A8.4a.1 | ||||||
R11A8.4b.1 | |||||||
Other_sequence (27) | |||||||
Associated_feature | WBsf652127 | ||||||
WBsf230722 | |||||||
WBsf230723 | |||||||
WBsf230724 | |||||||
Experimental_info | RNAi_result (22) | ||||||
Expr_pattern (11) | |||||||
Drives_construct | WBCnstr00000542 | ||||||
WBCnstr00000543 | |||||||
WBCnstr00000544 | |||||||
WBCnstr00001714 | |||||||
WBCnstr00004909 | |||||||
WBCnstr00009072 | |||||||
WBCnstr00016017 | |||||||
WBCnstr00016018 | |||||||
WBCnstr00016019 | |||||||
WBCnstr00016020 | |||||||
WBCnstr00016021 | |||||||
WBCnstr00016022 | |||||||
WBCnstr00018687 | |||||||
WBCnstr00018688 | |||||||
WBCnstr00018690 | |||||||
WBCnstr00018691 | |||||||
WBCnstr00018708 | |||||||
WBCnstr00035381 | |||||||
Construct_product (18) | |||||||
Regulate_expr_cluster (22) | |||||||
Antibody | WBAntibody00001101 | ||||||
WBAntibody00001123 | |||||||
WBAntibody00001697 | |||||||
WBAntibody00001698 | |||||||
Microarray_results (26) | |||||||
Expression_cluster (97) | |||||||
Interaction (156) | |||||||
WBProcess | WBbiopr:00000001 | ||||||
WBbiopr:00000121 | |||||||
Map_info | Map | IV | Position | 4.57839 | Error | 0.000393 | |
Positive | Positive_clone | R11A8 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 4660 | |||||
Pseudo_map_position | |||||||
Reference (245) | |||||||
Remark | Sequence connection from [Tissenbaum HA] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |