Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00004800

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00004800SMapS_parentSequenceR11A8
IdentityVersion1
NameCGC_namesir-2.1Person_evidenceWBPerson1840
Sequence_nameR11A8.4
Molecular_nameR11A8.4a
R11A8.4a.1
CE06302
R11A8.4b
CE44629
R11A8.4b.1
Other_nameCELE_R11A8.4Accession_evidenceNDBBX284604
Public_namesir-2.1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:36WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classsir
Allele (42)
StrainWBStrain00024177
WBStrain00022167
WBStrain00026544
WBStrain00035578
WBStrain00047283
RNASeq_FPKM (74)
GO_annotation00007464
00007465
00007466
00007467
00007468
00007469
00007470
00007471
00007472
00007473
00073309
00073310
00073311
00073312
00073313
00073314
00073315
00073316
00073317
00073318
00073319
00073320
00073321
00073322
00073323
00073324
00073325
00073326
00073327
00073328
00073329
00073330
00073331
00073332
00073333
00113203
Contained_in_operonCEOP4372
Ortholog (42)
ParalogWBGene00014769Caenorhabditis elegansFrom_analysismodENCODE_Pseudogenes
WBGene00004801Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00004802Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00004803Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionsir-2.1 encodes an NAD-dependent protein deacetylase with similarity to Saccharomyces cerevisiae Sir2p and mammalian SIRT1.Paper_evidenceWBPaper00004566
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated14 Nov 2014 00:00:00
Automated_descriptionEnables deacetylase activity. Involved in dauer larval development; determination of adult lifespan; and intrinsic apoptotic signaling pathway in response to DNA damage. Located in chromosome, telomeric region; nucleus; and perinuclear region of cytoplasm. Expressed in several structures, including intestinal cell; neurons; retrovesicular ganglion; tail; and ventral nerve cord. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; non-alcoholic fatty liver disease; and senile cataract. Is an ortholog of human SIRT1 (sirtuin 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:1574Homo sapiensPaper_evidenceWBPaper00041098
Curator_confirmedWBPerson324
Date_last_updated21 May 2019 00:00:00
Potential_modelDOID:9669Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:14929)
DOID:12858Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:14929)
DOID:10283Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:14929)
DOID:4448Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:14929)
DOID:0080208Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:14929)
DOID:1826Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:14929)
Models_disease_assertedWBDOannot00000675
Molecular_infoCorresponding_CDSR11A8.4a
R11A8.4b
Corresponding_transcriptR11A8.4a.1
R11A8.4b.1
Other_sequence (27)
Associated_featureWBsf652127
WBsf230722
WBsf230723
WBsf230724
Experimental_infoRNAi_result (22)
Expr_pattern (11)
Drives_construct (18)
Construct_product (18)
Regulate_expr_cluster (22)
AntibodyWBAntibody00001101
WBAntibody00001123
WBAntibody00001697
WBAntibody00001698
Microarray_results (26)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00033065:isp-1-1(qm150)_upregulated
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:bodywall-muscle_L1-larva_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:bodywall-muscle_larva_enriched
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00045521:Gender_Neutral
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00048988:neuron_expressed
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
WBPaper00049920:Glucose-Diet_downregulated_N2
WBPaper00049942:hsf-1(RNAi)_downregulated
WBPaper00050015:ifg-1(RNAi)_downregulated
WBPaper00050344:AFD-neuron_enriched
WBPaper00050488:20C_vs_25C_regulated_N2_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00051039:germline_enriched
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
WBPaper00054626:NO_upregulated
WBPaper00055648:germline_expressed
WBPaper00056034:pals-22(jy3)_downregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056139:soil-microbiota_downregulated
WBPaper00056619:CEPsh_enriched
WBPaper00058691:set-2(bn129)_upregulated
WBPaper00058725:sftb-1(cer6)_upregulated
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059567:olrn-1(ums9)_regulated
WBPaper00059763:neuron_expressed
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00061340:Neuroblast_AFD_RMD
WBPaper00061340:RIA_parent
WBPaper00061439:unc-30(ok613)_downregulated
WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061527:skr-16-F37B4.10
WBPaper00061572:oleic-acid-specific_mating_upregulated
WBPaper00061902:camt-1(ok515)_regulated_RMG
WBPaper00062159:hda-2(ok1479)_downregulated
WBPaper00062193:hsf-1(RNAi)_downregulated
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062325:etr-1(lq61)_downregulated
WBPaper00062325:etr-1(lq61)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064163:ZNFX-1_interacting_embryo
WBPaper00064716:paraquat_upregulated
WBPaper00064939:vit-5(RNAi)_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066062:xrep-4(lax137)_upregulated
WBPaper00066110:tetraploid_vs_diploid_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
cgc4489_group_7
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00031532:Larva_Pan_Neuronal_Enriched
WBPaper00036286:Pattern_B
WBPaper00036286:Pattern_H
WBPaper00040858:eQTL_age_regulated_aging
WBPaper00040858:eQTL_regulated_old
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_EtBr-exposed_51h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00044091:Bpseudomallei_induced_12h
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(53_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
[cgc6390]:herm_sex-enriched
Interaction (156)
WBProcessWBbiopr:00000001
WBbiopr:00000121
Map_infoMapIVPosition4.57839Error0.000393
PositivePositive_cloneR11A8Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4660
Pseudo_map_position
Reference (245)
RemarkSequence connection from [Tissenbaum HA]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene