WormBase Tree Display for Gene: WBGene00004800

WBGene00004800 SMap: S_parent: Sequence: R11A8
  Identity: Version: 1
    Name: CGC_name: sir-2.1 Person_evidence: WBPerson1840
      Sequence_name: R11A8.4
      Molecular_name: R11A8.4a
        R11A8.4a.1
        CE06302
        R11A8.4b
        CE44629
        R11A8.4b.1
      Other_name: CELE_R11A8.4 Accession_evidence: NDB BX284604
      Public_name: sir-2.1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sir
    Allele (42)
    Strain: WBStrain00024177
      WBStrain00022167
      WBStrain00026544
      WBStrain00035578
      WBStrain00047283
    RNASeq_FPKM (74)
    GO_annotation (36)
    Contained_in_operon: CEOP4372
    Ortholog (42)
    Paralog: WBGene00014769 Caenorhabditis elegans From_analysis: modENCODE_Pseudogenes
      WBGene00004801 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004802 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004803 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: sir-2.1 encodes an NAD-dependent protein deacetylase with similarity to Saccharomyces cerevisiae Sir2p and mammalian SIRT1. Paper_evidence: WBPaper00004566
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 14 Nov 2014 00:00:00
      Automated_description: Enables deacetylase activity. Involved in dauer larval development; determination of adult lifespan; and intrinsic apoptotic signaling pathway in response to DNA damage. Located in chromosome, telomeric region; nucleus; and perinuclear region of cytoplasm. Expressed in several structures, including intestinal cell; neurons; retrovesicular ganglion; tail; and ventral nerve cord. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; non-alcoholic fatty liver disease; and senile cataract. Is an ortholog of human SIRT1 (sirtuin 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:1574 Homo sapiens Paper_evidence: WBPaper00041098
          Curator_confirmed: WBPerson324
          Date_last_updated: 21 May 2019 00:00:00
    Potential_model: DOID:9669 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14929)
      DOID:12858 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14929)
      DOID:10283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14929)
      DOID:4448 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14929)
      DOID:0080208 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14929)
      DOID:1826 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14929)
  Models_disease_asserted: WBDOannot00000675
  Molecular_info: Corresponding_CDS: R11A8.4a
      R11A8.4b
    Corresponding_transcript: R11A8.4a.1
      R11A8.4b.1
    Other_sequence (27)
    Associated_feature: WBsf652127
      WBsf230722
      WBsf230723
      WBsf230724
  Experimental_info: RNAi_result (22)
    Expr_pattern (11)
    Drives_construct: WBCnstr00000542
      WBCnstr00000543
      WBCnstr00000544
      WBCnstr00001714
      WBCnstr00004909
      WBCnstr00009072
      WBCnstr00016017
      WBCnstr00016018
      WBCnstr00016019
      WBCnstr00016020
      WBCnstr00016021
      WBCnstr00016022
      WBCnstr00018687
      WBCnstr00018688
      WBCnstr00018690
      WBCnstr00018691
      WBCnstr00018708
      WBCnstr00035381
    Construct_product (18)
    Regulate_expr_cluster (22)
    Antibody: WBAntibody00001101
      WBAntibody00001123
      WBAntibody00001697
      WBAntibody00001698
    Microarray_results (26)
    Expression_cluster (97)
    Interaction (156)
    WBProcess: WBbiopr:00000001
      WBbiopr:00000121
  Map_info: Map: IV Position: 4.57839 Error: 0.000393
    Positive: Positive_clone: R11A8 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4660
    Pseudo_map_position
  Reference: WBPaper00004566
    WBPaper00004817
    WBPaper00005475
    WBPaper00005697
    WBPaper00005715
    WBPaper00005811
    WBPaper00005870
    WBPaper00006520
    WBPaper00010298
    WBPaper00013133
    WBPaper00017903
    WBPaper00018853
    WBPaper00024072
    WBPaper00024298
    WBPaper00024393
    WBPaper00025055
    WBPaper00025195
    WBPaper00025295
    WBPaper00026089
    WBPaper00026231
    WBPaper00026643
    WBPaper00026929
    WBPaper00026947
    WBPaper00027148
    WBPaper00027338
    WBPaper00027421
    WBPaper00027682
    WBPaper00027763
    WBPaper00028759
    WBPaper00028760
    WBPaper00028790
    WBPaper00028983
    WBPaper00029007
    WBPaper00029008
    WBPaper00029019
    WBPaper00029149
    WBPaper00029298
    WBPaper00030955
    WBPaper00030988
    WBPaper00031034
    WBPaper00031060
    WBPaper00031132
    WBPaper00031326
    WBPaper00031629
    WBPaper00031715
    WBPaper00032003
    WBPaper00032268
    WBPaper00032390
    WBPaper00032622
    WBPaper00032932
    WBPaper00033091
    WBPaper00033112
    WBPaper00033162
    WBPaper00033203
    WBPaper00033279
    WBPaper00033299
    WBPaper00033401
    WBPaper00033448
    WBPaper00033907
    WBPaper00033944
    WBPaper00034437
    WBPaper00034502
    WBPaper00034717
    WBPaper00034891
    WBPaper00035173
    WBPaper00035248
    WBPaper00035442
    WBPaper00035479
    WBPaper00036044
    WBPaper00036067
    WBPaper00036140
    WBPaper00036354
    WBPaper00036476
    WBPaper00036572
    WBPaper00036573
    WBPaper00036730
    WBPaper00037043
    WBPaper00037128
    WBPaper00037149
    WBPaper00037367
    WBPaper00037393
    WBPaper00037420
    WBPaper00037688
    WBPaper00037741
    WBPaper00038046
    WBPaper00038093
    WBPaper00038329
    WBPaper00038372
    WBPaper00038386
    WBPaper00038491
    WBPaper00038741
    WBPaper00038954
    WBPaper00038966
    WBPaper00038989
    WBPaper00039001
    WBPaper00039540
    WBPaper00039819
    WBPaper00039978
    WBPaper00040109
    WBPaper00040132
    WBPaper00040139
    WBPaper00040154
    WBPaper00040184
    WBPaper00040229
    WBPaper00040786
    WBPaper00040843
    WBPaper00041375
    WBPaper00041624
    WBPaper00041837
    WBPaper00042021
    WBPaper00042090
    WBPaper00042106
    WBPaper00042148
    WBPaper00042269
    WBPaper00042375
    WBPaper00042478
    WBPaper00043042
    WBPaper00043048
    WBPaper00043085
    WBPaper00043659
    WBPaper00043666
    WBPaper00043942
    WBPaper00044152
    WBPaper00044260
    WBPaper00044426
    WBPaper00044584
    WBPaper00044685
    WBPaper00044730
    WBPaper00044735
    WBPaper00044873
    WBPaper00045006
    WBPaper00045075
    WBPaper00045170
    WBPaper00045295
    WBPaper00045297
    WBPaper00045410
    WBPaper00045581
    WBPaper00045631
    WBPaper00045681
    WBPaper00045808
    WBPaper00045933
    WBPaper00046016
    WBPaper00046162
    WBPaper00046394
    WBPaper00046413
    WBPaper00046579
    WBPaper00046620
    WBPaper00046807
    WBPaper00047022
    WBPaper00047109
    WBPaper00047492
    WBPaper00047595
    WBPaper00048151
    WBPaper00048426
    WBPaper00048625
    WBPaper00048895
    WBPaper00048955
    WBPaper00049277
    WBPaper00049502
    WBPaper00049675
    WBPaper00049944
    WBPaper00049999
    WBPaper00050219
    WBPaper00050434
    WBPaper00050459
    WBPaper00050602
    WBPaper00050737
    WBPaper00050843
    WBPaper00050950
    WBPaper00051037
    WBPaper00051233
    WBPaper00051287
    WBPaper00051389
    WBPaper00051440
    WBPaper00051561
    WBPaper00051627
    WBPaper00051635
    WBPaper00051659
    WBPaper00052954
    WBPaper00053098
    WBPaper00053133
    WBPaper00053146
    WBPaper00053368
    WBPaper00053409
    WBPaper00053539
    WBPaper00053663
    WBPaper00053706
    WBPaper00054153
    WBPaper00054735
    WBPaper00054831
    WBPaper00054838
    WBPaper00054866
    WBPaper00054925
    WBPaper00055090
    WBPaper00055136
    WBPaper00055782
    WBPaper00055972
    WBPaper00057060
    WBPaper00057113
    WBPaper00057215
    WBPaper00057361
    WBPaper00057445
    WBPaper00058649
    WBPaper00058829
    WBPaper00058832
    WBPaper00059352
    WBPaper00059393
    WBPaper00059451
    WBPaper00059457
    WBPaper00059512
    WBPaper00059520
    WBPaper00059553
    WBPaper00059799
    WBPaper00059947
    WBPaper00060664
    WBPaper00061159
    WBPaper00061254
    WBPaper00061304
    WBPaper00061470
    WBPaper00061547
    WBPaper00061579
    WBPaper00061590
    WBPaper00061835
    WBPaper00062011
    WBPaper00062335
    WBPaper00062799
    WBPaper00063345
    WBPaper00063917
    WBPaper00063994
    WBPaper00064212
    WBPaper00064258
    WBPaper00064306
    WBPaper00064362
    WBPaper00064498
    WBPaper00064668
    WBPaper00064747
    WBPaper00064853
    WBPaper00064904
    WBPaper00064912
    WBPaper00064915
    WBPaper00065090
    WBPaper00065263
    WBPaper00065308
    WBPaper00065864
    WBPaper00066067
  Remark: Sequence connection from [Tissenbaum HA]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene