WormBase Tree Display for Gene: WBGene00004798
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| WBGene00004798 | SMap | S_parent | Sequence | F43D9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | sip-1 | Person_evidence | WBPerson1414 | |||||
| Sequence_name | F43D9.4 | ||||||||
| Molecular_name | F43D9.4 | ||||||||
| F43D9.4.1 | |||||||||
| CE00994 | |||||||||
| Other_name | SIP/1 | ||||||||
| sec-1 | |||||||||
| CELE_F43D9.4 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | sip-1 | ||||||||
| DB_info | Database | AceView | gene | 3L596 | |||||
| WormQTL | gene | WBGene00004798 | |||||||
| WormFlux | gene | WBGene00004798 | |||||||
| NDB | locus_tag | CELE_F43D9.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004798|UniProtKB=Q20363 | |||||||
| family | PTHR45640 | ||||||||
| NCBI | gene | 176471 | |||||||
| RefSeq | protein | NM_066915.5 | |||||||
| SwissProt | UniProtAcc | Q20363 | |||||||
| UniProt_GCRP | UniProtAcc | Q20363 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sip | ||||||||
| Allele (18) | |||||||||
| Legacy_information | [C.elegansII] NMK. Expression in gonad and early embryo increased after treatment with > 0.2 mM cadmium. Encodes novel protein related to heat shock proteins. [CR] | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (12) | |||||||||
| Ortholog (36) | |||||||||
| Paralog (17) | |||||||||
| Structured_description | Concise_description | sip-1 encodes a member of the small heat shock family of proteins; loss of sip-1 function via antisense or large-scale RNAi experiments results in embryonic lethality and in a small but reproducible reduction in lifespan in otherwise long-lived animals, respectively, suggesting that sip-1 plays a role in embryonic development as well as regulation of adult lifespan; in addition, expression of sip-1 in E. coli is able to confer thermotolerance on the bacterium; sip-1 mRNA is detected in oocytes and developing embryos, with SIP-1 protein abundant and widely expressed in embryos that have not yet begun morphogenesis; sip-1 expression is regulated by the insulin/IGF-1 signaling (IIS) pathway. | Paper_evidence | WBPaper00002615 | |||||
| WBPaper00005976 | |||||||||
| WBPaper00006377 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 23 Sep 2010 00:00:00 | ||||||||
| Automated_description | Predicted to enable unfolded protein binding activity. Involved in several processes, including determination of adult lifespan; embryo development; and response to heat. Located in cytosol. Expressed in body wall musculature and gonad. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F43D9.4 | |||||||
| Corresponding_transcript | F43D9.4.1 | ||||||||
| Other_sequence (50) | |||||||||
| Associated_feature | WBsf651460 | ||||||||
| WBsf667395 | |||||||||
| WBsf667396 | |||||||||
| WBsf976005 | |||||||||
| WBsf976006 | |||||||||
| WBsf976007 | |||||||||
| WBsf976008 | |||||||||
| WBsf976009 | |||||||||
| WBsf227467 | |||||||||
| WBsf227468 | |||||||||
| Experimental_info | RNAi_result (19) | ||||||||
| Expr_pattern | Expr1607 | ||||||||
| Expr1608 | |||||||||
| Expr12380 | |||||||||
| Expr14422 | |||||||||
| Expr15512 | |||||||||
| Expr1025283 | |||||||||
| Expr1032381 | |||||||||
| Expr1151051 | |||||||||
| Expr2015821 | |||||||||
| Expr2034054 | |||||||||
| Drives_construct | WBCnstr00035382 | ||||||||
| WBCnstr00040852 | |||||||||
| WBCnstr00042203 | |||||||||
| Construct_product | WBCnstr00035382 | ||||||||
| WBCnstr00042203 | |||||||||
| Antibody | WBAntibody00001798 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (325) | |||||||||
| Interaction (1036) | |||||||||
| WBProcess | WBbiopr:00000053 | ||||||||
| Map_info | Map | III | Position | 2.93581 | Error | 0.122939 | |||
| Positive | Positive_clone | CR#7A-2 | |||||||
| F43D9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 5626 | |||||||
| Pseudo_map_position | |||||||||
| Reference (32) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
