WormBase Tree Display for Gene: WBGene00004798
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WBGene00004798 | SMap | S_parent | Sequence | F43D9 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | sip | ||||||
Allele (18) | |||||||
Legacy_information | [C.elegansII] NMK. Expression in gonad and early embryo increased after treatment with > 0.2 mM cadmium. Encodes novel protein related to heat shock proteins. [CR] | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (12) | |||||||
Ortholog (36) | |||||||
Paralog (17) | |||||||
Structured_description | Concise_description | sip-1 encodes a member of the small heat shock family of proteins; loss of sip-1 function via antisense or large-scale RNAi experiments results in embryonic lethality and in a small but reproducible reduction in lifespan in otherwise long-lived animals, respectively, suggesting that sip-1 plays a role in embryonic development as well as regulation of adult lifespan; in addition, expression of sip-1 in E. coli is able to confer thermotolerance on the bacterium; sip-1 mRNA is detected in oocytes and developing embryos, with SIP-1 protein abundant and widely expressed in embryos that have not yet begun morphogenesis; sip-1 expression is regulated by the insulin/IGF-1 signaling (IIS) pathway. | Paper_evidence | WBPaper00002615 | |||
WBPaper00005976 | |||||||
WBPaper00006377 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 23 Sep 2010 00:00:00 | ||||||
Automated_description | Predicted to enable unfolded protein binding activity. Involved in several processes, including determination of adult lifespan; embryo development; and response to heat. Located in cytosol. Expressed in body wall musculature and gonad. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | F43D9.4 | |||||
Corresponding_transcript | F43D9.4.1 | ||||||
Other_sequence (50) | |||||||
Associated_feature | WBsf651460 | ||||||
WBsf667395 | |||||||
WBsf667396 | |||||||
WBsf976005 | |||||||
WBsf976006 | |||||||
WBsf976007 | |||||||
WBsf976008 | |||||||
WBsf976009 | |||||||
WBsf227467 | |||||||
WBsf227468 | |||||||
Experimental_info | RNAi_result (19) | ||||||
Expr_pattern | Expr1607 | ||||||
Expr1608 | |||||||
Expr12380 | |||||||
Expr14422 | |||||||
Expr15512 | |||||||
Expr1025283 | |||||||
Expr1032381 | |||||||
Expr1151051 | |||||||
Expr2015821 | |||||||
Expr2034054 | |||||||
Drives_construct | WBCnstr00035382 | ||||||
WBCnstr00040852 | |||||||
WBCnstr00042203 | |||||||
Construct_product | WBCnstr00035382 | ||||||
WBCnstr00042203 | |||||||
Antibody | WBAntibody00001798 | ||||||
Microarray_results (21) | |||||||
Expression_cluster (325) | |||||||
Interaction (1036) | |||||||
WBProcess | WBbiopr:00000053 | ||||||
Map_info | Map | III | Position | 2.93581 | Error | 0.122939 | |
Positive | Positive_clone | CR#7A-2 | |||||
F43D9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 5626 | |||||
Pseudo_map_position | |||||||
Reference (32) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |