WormBase Tree Display for Gene: WBGene00004786

WBGene00004786 Evidence: Paper_evidence: WBPaper00003081
      WBPaper00003416
  SMap: S_parent: Sequence: F44A6
  Identity: Version: 1
    Name: CGC_name: sex-1 Person_evidence: WBPerson421
      Sequence_name: F44A6.2
      Molecular_name: F44A6.2
        F44A6.2.1
        CE03323
      Other_name: nhr-24
        cnr14 Accession_evidence: EMBL U13074
        CELE_F44A6.2 Accession_evidence: NDB BX284606
      Public_name: sex-1
    DB_info: Database: WormQTL gene WBGene00004786
        WormFlux gene WBGene00004786
        NDB locus_tag CELE_F44A6.2
        Panther gene CAEEL|WormBase=WBGene00004786|UniProtKB=P41830
          family PTHR24082
        NCBI gene 181231
        RefSeq protein NM_001029491.5
        SwissProt UniProtAcc P41830
        TREEFAM TREEFAM_ID TF352096
        UniProt_GCRP UniProtAcc P41830
        OMIM gene 180220
            180240
            601487
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sex
    Allele (66)
    Legacy_information: sex-1 for Signal Element on X. sex-1 hermaphrodites are Dpy, Egl and Tra, males are wild type. Encodes predicted nuclear hormone receptor, gene F44A6.2,published as CNR14 by Kostrouch et al. (1995), aka nhr-24
    Strain: WBStrain00028733
      WBStrain00035136
      WBStrain00036740
      WBStrain00036791
      WBStrain00036806
    RNASeq_FPKM (74)
    GO_annotation (28)
    Ortholog: WBGene00063113 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            WormBase-Compara
      WBGene00036894 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            WormBase-Compara
      WBGene00152210 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            WormBase-Compara
      WBGene00124484 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            WormBase-Compara
      WBGene00145412 Caenorhabditis brenneri From_analysis: WormBase-Compara
      CBOVI.g2928 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP26.g20640 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP26.g9688 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g17553 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP28.g7000 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g16065 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP29.g5957 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g25101 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g12730 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g3504 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g27396 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g15884 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00008.g707 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-sex-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g13695 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00005.g375 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_01121.g18558 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_01365 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_023541 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g07329 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g4374 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_X0067600 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g19868 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00272173 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00259720 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00288560 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0004865 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-990415-244 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-980526-531 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-980526-284 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
      ZFIN:ZDB-GENE-040504-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            SonicParanoid
      ZFIN:ZDB-GENE-050105-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-980526-72 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-070314-1 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      HGNC:9236 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
            Panther
      HGNC:9864 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      HGNC:9865 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      HGNC:9866 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      HGNC:7962 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Panther
            SonicParanoid
      HGNC:7963 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Panther
            SonicParanoid
      MGI:97856 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      MGI:97858 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      MGI:2444210 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Panther
            SonicParanoid
      MGI:97857 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
      MGI:2449205 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Panther
            SonicParanoid
      RGD:3534 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      RGD:3535 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
      RGD:3371 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:628827 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Panther
            SonicParanoid
      RGD:628828 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Panther
            SonicParanoid
      RGD:1583230 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
    Paralog (217)
    Structured_description: Concise_description: sex-1 encodes a DNA-binding protein that is a member of the nuclear hormone receptor superfamily of transcriptional regulators; during embryonic development, SEX-1 functions as an X chromosome signal element that transmits the primary sex-determination signal by negatively regulating transcription of xol-1, a gene whose expression levels correlate with hermaphrodite or male development (low xol-1 levels result in hermaphrodite development, high xol-1, in that of males); in vivo, SEX-1 can associate with extrachromosomal arrays containing the xol-1 promoter, indicating that SEX-1's affect on xol-1 transcription is likely to be direct; SEX-1 localizes to nuclei from oogenesis through mid-embryogenesis, with highest levels of expression visible during early gastrulation (28-100-cell-stage); the SEX-1 expression pattern appears to be similar in hermaphrodites and males. Paper_evidence: WBPaper00003262
          Curator_confirmed: WBPerson1843
          Date_last_updated: 12 Oct 2005 00:00:00
      Automated_description: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in primary sex determination and regulation of gene expression. Located in nucleus. Expressed in gonad; intestine; oocyte; and ventral uterine precursor. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); liver disease (multiple); and lung carcinoma (multiple). Is an ortholog of human NR1D1 (nuclear receptor subfamily 1 group D member 1) and NR1D2 (nuclear receptor subfamily 1 group D member 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (27)
  Molecular_info: Corresponding_CDS: F44A6.2
    Corresponding_CDS_history: F44A6.2a:wp144
      F44A6.2b:wp144
    Corresponding_transcript: F44A6.2.1
    Other_sequence: U13074
      JI175482.1
      EF066631.1
      CR04735
      AF367207.1
      JI168358.1
      CRC05784_1
    Associated_feature (21)
    Transcription_factor: WBTranscriptionFactor000302
  Experimental_info: RNAi_result (40)
    Expr_pattern: Expr1581
      Expr7557
      Expr8032
      Expr15144
      Expr1016094
      Expr1032373
      Expr1151099
      Expr1200128
      Expr2015785
      Expr2034018
    Drives_construct: WBCnstr00012702
      WBCnstr00035389
    Construct_product: WBCnstr00016585
      WBCnstr00016774
      WBCnstr00035389
    Antibody: WBAntibody00000976
    Microarray_results (25)
    Expression_cluster (193)
    Interaction (105)
    WBProcess: WBbiopr:00000056
  Map_info: Map: X Position: 1.8824 Error: 0.018071
    Well_ordered
    Positive: Inside_rearr: stDp2
      Positive_clone: C06F4
        F44A6 Person_evidence: WBPerson600
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4909
      Pos_neg_data: 9151
  Reference (65)
  Remark: nhr-24 is predicted gene F44A6.2, pka cnr-14
    sex-1 designation takes precedence, nhr-24 retired [021217 ck1]
  Method: Gene