WormBase Tree Display for Gene: WBGene00004786

WBGene00004786 Evidence: Paper_evidence: WBPaper00003081
      WBPaper00003416
  SMap: S_parent: Sequence: F44A6
  Identity: Version: 1
    Name: CGC_name: sex-1 Person_evidence: WBPerson421
      Sequence_name: F44A6.2
      Molecular_name: F44A6.2
        F44A6.2.1
        CE03323
      Other_name: nhr-24
        cnr14 Accession_evidence: EMBL U13074
        CELE_F44A6.2 Accession_evidence: NDB BX284606
      Public_name: sex-1
    DB_info: Database: WormQTL gene WBGene00004786
        WormFlux gene WBGene00004786
        NDB locus_tag CELE_F44A6.2
        Panther gene CAEEL|WormBase=WBGene00004786|UniProtKB=P41830
          family PTHR24082
        NCBI gene 181231
        RefSeq protein NM_001029491.5
        SwissProt UniProtAcc P41830
        TREEFAM TREEFAM_ID TF352096
        UniProt_GCRP UniProtAcc P41830
        OMIM gene 180220
            180240
            601487
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sex
    Allele (66)
    Legacy_information: sex-1 for Signal Element on X. sex-1 hermaphrodites are Dpy, Egl and Tra, males are wild type. Encodes predicted nuclear hormone receptor, gene F44A6.2,published as CNR14 by Kostrouch et al. (1995), aka nhr-24
    Strain: WBStrain00028733
      WBStrain00035136
      WBStrain00036740
      WBStrain00036791
      WBStrain00036806
    RNASeq_FPKM (74)
    GO_annotation (28)
    Ortholog (56)
    Paralog (217)
    Structured_description: Concise_description: sex-1 encodes a DNA-binding protein that is a member of the nuclear hormone receptor superfamily of transcriptional regulators; during embryonic development, SEX-1 functions as an X chromosome signal element that transmits the primary sex-determination signal by negatively regulating transcription of xol-1, a gene whose expression levels correlate with hermaphrodite or male development (low xol-1 levels result in hermaphrodite development, high xol-1, in that of males); in vivo, SEX-1 can associate with extrachromosomal arrays containing the xol-1 promoter, indicating that SEX-1's affect on xol-1 transcription is likely to be direct; SEX-1 localizes to nuclei from oogenesis through mid-embryogenesis, with highest levels of expression visible during early gastrulation (28-100-cell-stage); the SEX-1 expression pattern appears to be similar in hermaphrodites and males. Paper_evidence: WBPaper00003262
          Curator_confirmed: WBPerson1843
          Date_last_updated: 12 Oct 2005 00:00:00
      Automated_description: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in primary sex determination and regulation of gene expression. Located in nucleus. Expressed in gonad; intestine; oocyte; and ventral uterine precursor. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); liver disease (multiple); and lung carcinoma (multiple). Is an ortholog of human NR1D1 (nuclear receptor subfamily 1 group D member 1) and NR1D2 (nuclear receptor subfamily 1 group D member 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (27)
  Molecular_info: Corresponding_CDS: F44A6.2
    Corresponding_CDS_history: F44A6.2a:wp144
      F44A6.2b:wp144
    Corresponding_transcript: F44A6.2.1
    Other_sequence: U13074
      JI175482.1
      EF066631.1
      CR04735
      AF367207.1
      JI168358.1
      CRC05784_1
    Associated_feature (21)
    Transcription_factor: WBTranscriptionFactor000302
  Experimental_info: RNAi_result (40)
    Expr_pattern: Expr1581
      Expr7557
      Expr8032
      Expr15144
      Expr1016094
      Expr1032373
      Expr1151099
      Expr1200128
      Expr2015785
      Expr2034018
    Drives_construct: WBCnstr00012702
      WBCnstr00035389
    Construct_product: WBCnstr00016585
      WBCnstr00016774
      WBCnstr00035389
    Antibody: WBAntibody00000976
    Microarray_results (25)
    Expression_cluster (193)
    Interaction: WBInteraction000000734
      WBInteraction000000735
      WBInteraction000000736
      WBInteraction000000789
      WBInteraction000000894
      WBInteraction000000895
      WBInteraction000000896
      WBInteraction000000897
      WBInteraction000001071
      WBInteraction000001072
      WBInteraction000003111
      WBInteraction000003198
      WBInteraction000003215
      WBInteraction000003249
      WBInteraction000003527
      WBInteraction000003620
      WBInteraction000004904
      WBInteraction000005257
      WBInteraction000005809
      WBInteraction000006034
      WBInteraction000006149
      WBInteraction000006158
      WBInteraction000006174
      WBInteraction000006258
      WBInteraction000006278
      WBInteraction000007796
      WBInteraction000009666
      WBInteraction000009837
      WBInteraction000029121
      WBInteraction000029467
      WBInteraction000030555
      WBInteraction000031706
      WBInteraction000031707
      WBInteraction000031708
      WBInteraction000051395
      WBInteraction000051396
      WBInteraction000051397
      WBInteraction000051398
      WBInteraction000051399
      WBInteraction000051400
      WBInteraction000051401
      WBInteraction000051402
      WBInteraction000052063
      WBInteraction000052064
      WBInteraction000052065
      WBInteraction000052078
      WBInteraction000052095
      WBInteraction000052096
      WBInteraction000052097
      WBInteraction000052217
      WBInteraction000052786
      WBInteraction000144325
      WBInteraction000166212
      WBInteraction000166220
      WBInteraction000166238
      WBInteraction000371768
      WBInteraction000384332
      WBInteraction000410041
      WBInteraction000502998
      WBInteraction000502999
      WBInteraction000503000
      WBInteraction000503001
      WBInteraction000503377
      WBInteraction000503378
      WBInteraction000520339
      WBInteraction000525438
      WBInteraction000525535
      WBInteraction000526909
      WBInteraction000527191
      WBInteraction000527192
      WBInteraction000527193
      WBInteraction000527194
      WBInteraction000527195
      WBInteraction000527196
      WBInteraction000527197
      WBInteraction000527198
      WBInteraction000527199
      WBInteraction000527200
      WBInteraction000527201
      WBInteraction000527202
      WBInteraction000527203
      WBInteraction000527204
      WBInteraction000527774
      WBInteraction000527798
      WBInteraction000528240
      WBInteraction000529391
      WBInteraction000529567
      WBInteraction000530024
      WBInteraction000530140
      WBInteraction000530506
      WBInteraction000530694
      WBInteraction000530725
      WBInteraction000530786
      WBInteraction000530868
      WBInteraction000531184
      WBInteraction000532611
      WBInteraction000533112
      WBInteraction000533299
      WBInteraction000533306
      WBInteraction000533422
      WBInteraction000533840
      WBInteraction000534015
      WBInteraction000534098
      WBInteraction000535200
      WBInteraction000548062
    WBProcess: WBbiopr:00000056
  Map_info: Map: X Position: 1.8824 Error: 0.018071
    Well_ordered
    Positive: Inside_rearr: stDp2
      Positive_clone: C06F4
        F44A6 Person_evidence: WBPerson600
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4909
      Pos_neg_data: 9151
  Reference (65)
  Remark: nhr-24 is predicted gene F44A6.2, pka cnr-14
    sex-1 designation takes precedence, nhr-24 retired [021217 ck1]
  Method: Gene