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WormBase Tree Display for Gene: WBGene00004773

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Name Class

WBGene00004773SMapS_parentSequenceCHROMOSOME_I
IdentityVersion1
NameCGC_namesem-4Person_evidenceWBPerson268
Sequence_nameF15C11.1
Molecular_nameF15C11.1
F15C11.1.1
CE17673
Other_nameCELE_F15C11.1Accession_evidenceNDBBX284601
Public_namesem-4
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:36WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classsem
AlleleWBVar00145414Inferred_automaticallyFrom strain object: EW35
WBVar00090315Inferred_automaticallyFrom strain object: MT5825
From strain object: MT5884
WBVar00088334
WBVar00090147
WBVar00090155
WBVar00242574
WBVar01622872
WBVar00647324
WBVar00647325
WBVar00647326
WBVar00647327
WBVar00647328
WBVar00647329
WBVar00647330
WBVar00647331
WBVar00647332
WBVar00647333
WBVar00647334
WBVar00647335
WBVar00647336
WBVar00337419
WBVar00647337
WBVar00337420
WBVar00647338
WBVar00337421
WBVar00337422
WBVar00647339
WBVar00647340
WBVar00337423
WBVar00647341
WBVar00337424
WBVar00337425
WBVar02124860
WBVar00647342
WBVar00337426
WBVar00647343
WBVar00337427
WBVar00647344
WBVar00337428
WBVar00647345
WBVar00647346
WBVar00337429
WBVar00337430
WBVar00647347
WBVar00647348
WBVar00337431
WBVar00337432
WBVar00647349
WBVar00647350
WBVar00337433
WBVar00337434
WBVar00647351
WBVar00337435
WBVar00647352
WBVar00337436
WBVar00647353
WBVar00647354
WBVar00337437
WBVar00647355
WBVar00337438
WBVar00647356
WBVar00337439
WBVar00337440
WBVar00647357
WBVar02148528
WBVar00647358
WBVar02148529
WBVar00647359
WBVar00647360
WBVar00647361
WBVar00647362
WBVar00647363
WBVar00647364
WBVar00647365
WBVar00647366
WBVar00647367
WBVar00647368
WBVar00647369
WBVar00146674
WBVar00647370
WBVar00647371
WBVar00647372
WBVar00647373
WBVar00647374
WBVar00647375
WBVar00647376
WBVar00647377
WBVar00647378
WBVar00647379
WBVar00647380
WBVar00090149
WBVar00647381
WBVar00647382
WBVar00647383
WBVar00647384
WBVar00647385
WBVar00249586
WBVar01411657
WBVar01475676
WBVar01475677
WBVar00154158
WBVar01499786
WBVar01641060
WBVar01499054
WBVar02014167
WBVar00142170
WBVar01498894
WBVar01488593
WBVar00088336
WBVar00255558
WBVar00088339
WBVar00090534
WBVar02127757
WBVar02127758
WBVar01283419
WBVar01283420
WBVar01498959
WBVar00142242
Legacy_information[C.elegansII] n1378 : Egl, hermaphrodite sex muscles fail to differentiate; additional axon and lineage defects. ME0 (severe Mab), HME3. OA3: h769, n2087, n1971 (stronger allele, two mesodermal and six neuronal cell types pleiotropically affected; 2 additional touch cells formed in tail), etc. Cloned: encodes predicted protein with 6 C2H2 zincfinger motifs. [Desai et al. 1988; Mitani et al. 1993; MT; NH; TU]
Strain (13)
RNASeq_FPKM (74)
GO_annotation (25)
Ortholog (50)
ParalogWBGene00017430Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionsem-4 encodes a zinc-finger protein; sem-4 activity is required for proper development of cells in neuronal, mesodermal, and vulval cell lineages; sem-4 activity is also required for transdifferentiation of the Y rectal cell to the PDA neuron during larval development; a SEM-4::GFP reporter fusions are widely expressed with fluorescence seen in a number of different cell types including neurons, hypodermis, vulval precursor cells, and tail blast cells such as B and F.Paper_evidenceWBPaper00002518
WBPaper00004300
WBPaper00040964
Curator_confirmedWBPerson1843
Date_last_updated04 Dec 2012 00:00:00
Automated_descriptionEnables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell differentiation; regulation of transcription by RNA polymerase II; and response to oxidative stress. Located in nucleus. Expressed in several structures, including HSN; M lineage cell; rectal epithelial cell; rectum; and tail hypodermis. Human ortholog(s) of this gene implicated in several diseases, including Duane retraction syndrome; Duane-radial ray syndrome; and Holt-Oram syndrome. Is an ortholog of human SALL1 (spalt like transcription factor 1) and SALL3 (spalt like transcription factor 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (13)
Molecular_infoCorresponding_CDSF15C11.1
Corresponding_transcriptF15C11.1.1
Other_sequence (20)
Associated_feature (28)
Gene_product_binds (380)
Transcription_factorWBTranscriptionFactor000098
Experimental_infoRNAi_result (17)
Expr_pattern (11)
Drives_constructWBCnstr00000795
WBCnstr00000796
WBCnstr00035398
Construct_productWBCnstr00000795
WBCnstr00000796
WBCnstr00015364
WBCnstr00016866
WBCnstr00035398
Microarray_results (24)
Expression_cluster (199)
Interaction (185)
WBProcessWBbiopr:00000020
WBbiopr:00000023
WBbiopr:00000115
Map_infoMapIPosition1.65489Error0.003417
Well_ordered
PositivePositive_cloneE02H2
F15C11Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point1446
1447
2089
4030
5026
5509
Pos_neg_data (5)
Reference (87)
MethodGene