WormBase Tree Display for Gene: WBGene00004773

WBGene00004773 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 1
    Name: CGC_name: sem-4 Person_evidence: WBPerson268
      Sequence_name: F15C11.1
      Molecular_name: F15C11.1
        F15C11.1.1
        CE17673
      Other_name: CELE_F15C11.1 Accession_evidence: NDB BX284601
      Public_name: sem-4
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sem
    Allele (118)
    Legacy_information: [C.elegansII] n1378 : Egl, hermaphrodite sex muscles fail to differentiate; additional axon and lineage defects. ME0 (severe Mab), HME3. OA3: h769, n2087, n1971 (stronger allele, two mesodermal and six neuronal cell types pleiotropically affected; 2 additional touch cells formed in tail), etc. Cloned: encodes predicted protein with 6 C2H2 zincfinger motifs. [Desai et al. 1988; Mitani et al. 1993; MT; NH; TU]
    Strain (13)
    RNASeq_FPKM (74)
    GO_annotation (25)
    Ortholog (50)
    Paralog: WBGene00017430 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: sem-4 encodes a zinc-finger protein; sem-4 activity is required for proper development of cells in neuronal, mesodermal, and vulval cell lineages; sem-4 activity is also required for transdifferentiation of the Y rectal cell to the PDA neuron during larval development; a SEM-4::GFP reporter fusions are widely expressed with fluorescence seen in a number of different cell types including neurons, hypodermis, vulval precursor cells, and tail blast cells such as B and F. Paper_evidence: WBPaper00002518
            WBPaper00004300
            WBPaper00040964
          Curator_confirmed: WBPerson1843
          Date_last_updated: 04 Dec 2012 00:00:00
      Automated_description: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell differentiation; regulation of transcription by RNA polymerase II; and response to oxidative stress. Located in nucleus. Expressed in several structures, including HSN; M lineage cell; rectal epithelial cell; rectum; and tail hypodermis. Human ortholog(s) of this gene implicated in several diseases, including Duane retraction syndrome; Duane-radial ray syndrome; and Holt-Oram syndrome. Is an ortholog of human SALL1 (spalt like transcription factor 1) and SALL3 (spalt like transcription factor 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (13)
  Molecular_info: Corresponding_CDS: F15C11.1
    Corresponding_transcript: F15C11.1.1
    Other_sequence (20)
    Associated_feature (28)
    Gene_product_binds (380)
    Transcription_factor: WBTranscriptionFactor000098
  Experimental_info: RNAi_result (17)
    Expr_pattern (11)
    Drives_construct: WBCnstr00000795
      WBCnstr00000796
      WBCnstr00035398
    Construct_product: WBCnstr00000795
      WBCnstr00000796
      WBCnstr00015364
      WBCnstr00016866
      WBCnstr00035398
    Microarray_results (24)
    Expression_cluster (199)
    Interaction: WBInteraction000001135
      WBInteraction000001136
      WBInteraction000001244
      WBInteraction000001245
      WBInteraction000001246
      WBInteraction000003143
      WBInteraction000003144
      WBInteraction000003341
      WBInteraction000003342
      WBInteraction000003635
      WBInteraction000004080
      WBInteraction000005804
      WBInteraction000005805
      WBInteraction000005806
      WBInteraction000005807
      WBInteraction000005808
      WBInteraction000006499
      WBInteraction000009361
      WBInteraction000009367
      WBInteraction000009394
      WBInteraction000009537
      WBInteraction000009686
      WBInteraction000009749
      WBInteraction000009782
      WBInteraction000028194
      WBInteraction000028393
      WBInteraction000029387
      WBInteraction000031179
      WBInteraction000031190
      WBInteraction000032621
      WBInteraction000033814
      WBInteraction000034254
      WBInteraction000034592
      WBInteraction000034925
      WBInteraction000034991
      WBInteraction000034993
      WBInteraction000034995
      WBInteraction000035313
      WBInteraction000035356
      WBInteraction000035427
      WBInteraction000036002
      WBInteraction000036299
      WBInteraction000037625
      WBInteraction000037748
      WBInteraction000037921
      WBInteraction000037922
      WBInteraction000038015
      WBInteraction000038606
      WBInteraction000038788
      WBInteraction000040285
      WBInteraction000040402
      WBInteraction000040413
      WBInteraction000040908
      WBInteraction000041331
      WBInteraction000041825
      WBInteraction000041850
      WBInteraction000042281
      WBInteraction000042672
      WBInteraction000042970
      WBInteraction000043669
      WBInteraction000043670
      WBInteraction000043745
      WBInteraction000044366
      WBInteraction000044840
      WBInteraction000045615
      WBInteraction000046860
      WBInteraction000047271
      WBInteraction000047343
      WBInteraction000047461
      WBInteraction000047462
      WBInteraction000047529
      WBInteraction000048455
      WBInteraction000049444
      WBInteraction000049573
      WBInteraction000049574
      WBInteraction000049593
      WBInteraction000049744
      WBInteraction000050016
      WBInteraction000134954
      WBInteraction000136026
      WBInteraction000149172
      WBInteraction000151378
      WBInteraction000152403
      WBInteraction000161326
      WBInteraction000161327
      WBInteraction000161328
      WBInteraction000165492
      WBInteraction000166009
      WBInteraction000166228
      WBInteraction000166229
      WBInteraction000166230
      WBInteraction000166231
      WBInteraction000166232
      WBInteraction000169661
      WBInteraction000172103
      WBInteraction000172104
      WBInteraction000179641
      WBInteraction000185233
      WBInteraction000196884
      WBInteraction000226237
      WBInteraction000226238
      WBInteraction000228744
      WBInteraction000228745
      WBInteraction000238819
      WBInteraction000244714
      WBInteraction000246717
      WBInteraction000248130
      WBInteraction000262189
      WBInteraction000270913
      WBInteraction000293314
      WBInteraction000297120
      WBInteraction000297247
      WBInteraction000306769
      WBInteraction000309277
      WBInteraction000309667
      WBInteraction000322319
      WBInteraction000328896
      WBInteraction000328899
      WBInteraction000333630
      WBInteraction000336741
      WBInteraction000341912
      WBInteraction000347535
      WBInteraction000361396
      WBInteraction000388245
      WBInteraction000408010
      WBInteraction000426209
      WBInteraction000427331
      WBInteraction000437744
      WBInteraction000439517
      WBInteraction000454661
      WBInteraction000455551
      WBInteraction000457877
      WBInteraction000459446
      WBInteraction000461631
      WBInteraction000466748
      WBInteraction000470025
      WBInteraction000501946
      WBInteraction000502309
      WBInteraction000503136
      WBInteraction000513408
      WBInteraction000521609
      WBInteraction000521610
      WBInteraction000524252
      WBInteraction000524253
      WBInteraction000524254
      WBInteraction000524255
      WBInteraction000524372
      WBInteraction000527182
      WBInteraction000527183
      WBInteraction000527184
      WBInteraction000527185
      WBInteraction000527186
      WBInteraction000527187
      WBInteraction000527188
      WBInteraction000527189
      WBInteraction000527190
      WBInteraction000528217
      WBInteraction000529204
      WBInteraction000529878
      WBInteraction000529939
      WBInteraction000530662
      WBInteraction000530782
      WBInteraction000531307
      WBInteraction000531589
      WBInteraction000531610
      WBInteraction000531773
      WBInteraction000532122
      WBInteraction000533779
      WBInteraction000533999
      WBInteraction000535163
      WBInteraction000542991
      WBInteraction000543020
      WBInteraction000543082
      WBInteraction000547021
      WBInteraction000547691
      WBInteraction000547791
      WBInteraction000547795
      WBInteraction000547799
      WBInteraction000547803
      WBInteraction000548969
      WBInteraction000548970
      WBInteraction000548971
      WBInteraction000555939
      WBInteraction000573580
      WBInteraction000574458
    WBProcess: WBbiopr:00000020
      WBbiopr:00000023
      WBbiopr:00000115
  Map_info: Map: I Position: 1.65489 Error: 0.003417
    Well_ordered
    Positive: Positive_clone: E02H2
        F15C11 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point (6)
      Pos_neg_data: 5332
        5341
        5349
        5365
        5680
  Reference (87)
  Method: Gene