WormBase Tree Display for Gene: WBGene00004773
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WBGene00004773 | SMap | S_parent | Sequence | CHROMOSOME_I | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | sem | ||||||
Allele (118) | |||||||
Legacy_information | [C.elegansII] n1378 : Egl, hermaphrodite sex muscles fail to differentiate; additional axon and lineage defects. ME0 (severe Mab), HME3. OA3: h769, n2087, n1971 (stronger allele, two mesodermal and six neuronal cell types pleiotropically affected; 2 additional touch cells formed in tail), etc. Cloned: encodes predicted protein with 6 C2H2 zincfinger motifs. [Desai et al. 1988; Mitani et al. 1993; MT; NH; TU] | ||||||
Strain (13) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (25) | |||||||
Ortholog (50) | |||||||
Paralog | WBGene00017430 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
Structured_description | Concise_description | sem-4 encodes a zinc-finger protein; sem-4 activity is required for proper development of cells in neuronal, mesodermal, and vulval cell lineages; sem-4 activity is also required for transdifferentiation of the Y rectal cell to the PDA neuron during larval development; a SEM-4::GFP reporter fusions are widely expressed with fluorescence seen in a number of different cell types including neurons, hypodermis, vulval precursor cells, and tail blast cells such as B and F. | Paper_evidence | WBPaper00002518 | |||
WBPaper00004300 | |||||||
WBPaper00040964 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 04 Dec 2012 00:00:00 | ||||||
Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell differentiation; regulation of transcription by RNA polymerase II; and response to oxidative stress. Located in nucleus. Expressed in several structures, including HSN; M lineage cell; rectal epithelial cell; rectum; and tail hypodermis. Human ortholog(s) of this gene implicated in several diseases, including Duane retraction syndrome; Duane-radial ray syndrome; and Holt-Oram syndrome. Is an ortholog of human SALL1 (spalt like transcription factor 1) and SALL3 (spalt like transcription factor 3). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (13) | ||||||
Molecular_info | Corresponding_CDS | F15C11.1 | |||||
Corresponding_transcript | F15C11.1.1 | ||||||
Other_sequence (20) | |||||||
Associated_feature (28) | |||||||
Gene_product_binds (380) | |||||||
Transcription_factor | WBTranscriptionFactor000098 | ||||||
Experimental_info | RNAi_result (17) | ||||||
Expr_pattern (11) | |||||||
Drives_construct | WBCnstr00000795 | ||||||
WBCnstr00000796 | |||||||
WBCnstr00035398 | |||||||
Construct_product | WBCnstr00000795 | ||||||
WBCnstr00000796 | |||||||
WBCnstr00015364 | |||||||
WBCnstr00016866 | |||||||
WBCnstr00035398 | |||||||
Microarray_results (24) | |||||||
Expression_cluster (199) | |||||||
Interaction (185) | |||||||
WBProcess | WBbiopr:00000020 | ||||||
WBbiopr:00000023 | |||||||
WBbiopr:00000115 | |||||||
Map_info | Map | I | Position | 1.65489 | Error | 0.003417 | |
Well_ordered | |||||||
Positive | Positive_clone | E02H2 | |||||
F15C11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 1446 | |||||
1447 | |||||||
2089 | |||||||
4030 | |||||||
5026 | |||||||
5509 | |||||||
Pos_neg_data | 5332 | ||||||
5341 | |||||||
5349 | |||||||
5365 | |||||||
5680 | |||||||
Reference (87) | |||||||
Method | Gene |