WormBase Tree Display for Gene: WBGene00004773

WBGene00004773 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 1
    Name: CGC_name: sem-4 Person_evidence: WBPerson268
      Sequence_name: F15C11.1
      Molecular_name: F15C11.1
        F15C11.1.1
        CE17673
      Other_name: CELE_F15C11.1 Accession_evidence: NDB BX284601
      Public_name: sem-4
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sem
    Allele (118)
    Legacy_information: [C.elegansII] n1378 : Egl, hermaphrodite sex muscles fail to differentiate; additional axon and lineage defects. ME0 (severe Mab), HME3. OA3: h769, n2087, n1971 (stronger allele, two mesodermal and six neuronal cell types pleiotropically affected; 2 additional touch cells formed in tail), etc. Cloned: encodes predicted protein with 6 C2H2 zincfinger motifs. [Desai et al. 1988; Mitani et al. 1993; MT; NH; TU]
    Strain (13)
    RNASeq_FPKM (74)
    GO_annotation (25)
    Ortholog: WBGene00070757 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00032062 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00163834 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00131542 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00192272 Caenorhabditis brenneri From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00195122 Pristionchus pacificus From_analysis: Inparanoid_8
      WBGene00111951 Pristionchus pacificus From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00223649 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g10479 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g12357 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g11340 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g13072 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g10716 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g118 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g15418 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g7806 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g13854 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g17943 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_04840.g19158 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-sem-4 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold625.g6344 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00290.g8777 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_07599 Caenorhabditis latens From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g14832 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g8159 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_10081100 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrI_pilon.g1293 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00236896 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00278228 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00259749 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00289652 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0000287 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      FB:FBgn0261648 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-020228-2 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-020228-4 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-030131-9140 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-060328-2 Danio rerio From_analysis: Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-020228-3 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:10526 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:10524 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:10527 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:15924 Homo sapiens From_analysis: Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:109295 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1354373 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            Panther
            SonicParanoid
      MGI:1889585 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
            SonicParanoid
      MGI:2139360 Mus musculus From_analysis: Inparanoid
            OrthoFinder
            Panther
            SonicParanoid
      RGD:1309272 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1309916 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1310232 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
            SonicParanoid
      RGD:1597672 Rattus norvegicus From_analysis: Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
    Paralog: WBGene00017430 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: sem-4 encodes a zinc-finger protein; sem-4 activity is required for proper development of cells in neuronal, mesodermal, and vulval cell lineages; sem-4 activity is also required for transdifferentiation of the Y rectal cell to the PDA neuron during larval development; a SEM-4::GFP reporter fusions are widely expressed with fluorescence seen in a number of different cell types including neurons, hypodermis, vulval precursor cells, and tail blast cells such as B and F. Paper_evidence: WBPaper00002518
            WBPaper00004300
            WBPaper00040964
          Curator_confirmed: WBPerson1843
          Date_last_updated: 04 Dec 2012 00:00:00
      Automated_description: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell differentiation; regulation of transcription by RNA polymerase II; and response to oxidative stress. Located in nucleus. Expressed in several structures, including HSN; M lineage cell; rectal epithelial cell; rectum; and tail hypodermis. Human ortholog(s) of this gene implicated in several diseases, including Duane retraction syndrome; Duane-radial ray syndrome; and Holt-Oram syndrome. Is an ortholog of human SALL1 (spalt like transcription factor 1) and SALL3 (spalt like transcription factor 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (13)
  Molecular_info: Corresponding_CDS: F15C11.1
    Corresponding_transcript: F15C11.1.1
    Other_sequence (20)
    Associated_feature (28)
    Gene_product_binds (380)
    Transcription_factor: WBTranscriptionFactor000098
  Experimental_info: RNAi_result (17)
    Expr_pattern (11)
    Drives_construct: WBCnstr00000795
      WBCnstr00000796
      WBCnstr00035398
    Construct_product: WBCnstr00000795
      WBCnstr00000796
      WBCnstr00015364
      WBCnstr00016866
      WBCnstr00035398
    Microarray_results: SMD_F15C11.1
      175707_s_at
      193521_s_at
      A_12_P112731
      A_12_P156520
      A_12_P156521
      A_12_P156522
      A_12_P156523
      Aff_F15C11.1
      GPL13394_WBGene00004773
      GPL13914_F15C11.1
      GPL14144_F15C11.1_1706-1765_0.917_10_C
      GPL14144_F15C11.1_1779-1838_0.924_6_B
      GPL14144_F15C11.1_1910-1969_0.954_1_A
      GPL19516_CGZ0016470
      GPL21109_F15C11.1
      GPL3518_CE17673
      GPL8304_CE_WBGene00004773_A
      GPL8304_CE_WBGene00004773_B
      GPL8673_F15C11_1P00735
      GPL8673_F15C11_1P01372
      GPL8673_F15C11_1P01848
      GPL9450_F15C11.1
      cea2.c.02241
    Expression_cluster (199)
    Interaction (185)
    WBProcess: WBbiopr:00000020
      WBbiopr:00000023
      WBbiopr:00000115
  Map_info: Map: I Position: 1.65489 Error: 0.003417
    Well_ordered
    Positive: Positive_clone: E02H2
        F15C11 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 1446
        1447
        2089
        4030
        5026
        5509
      Pos_neg_data: 5332
        5341
        5349
        5365
        5680
  Reference (87)
  Method: Gene