WormBase Tree Display for Gene: WBGene00004754
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| WBGene00004754 | SMap | S_parent | Sequence | Y113G7A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | sec-23 | Person_evidence | WBPerson297 | |||||
| Sequence_name | Y113G7A.3 | ||||||||
| Molecular_name | Y113G7A.3 | ||||||||
| Y113G7A.3.1 | |||||||||
| CE27230 | |||||||||
| Other_name | Y113G7A.n | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_Y113G7A.3 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | sec-23 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sec | ||||||||
| Allele (341) | |||||||||
| Strain | WBStrain00008607 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (44) | |||||||||
| Structured_description | Concise_description | sec-23 encodes a component of COPII (coat protein complex II)-coated vesicles orthologous to Saccharomyces cerevisiae Sec23p; by homology, SEC-23 is predicted to be involved in endoplasmic reticulum (ER)-to-Golgi transport; loss of sec-23 activity results in defects in oogenesis, morphogenesis, and extracellular matrix secretion; a SEC-23::GFP fusion protein localizes to the apical region of the endoplasmic reticulum of hypodermal cells, consistent with localization to endoplasmic reticulum exit sites. | Paper_evidence | WBPaper00006236 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 02 May 2014 00:00:00 | ||||||||
| Automated_description | Predicted to enable GTPase activator activity. Predicted to be involved in COPII-coated vesicle cargo loading. Located in endoplasmic reticulum exit site. Expressed in hypodermis. Human ortholog(s) of this gene implicated in Cowden syndrome 7; congenital dyserythropoietic anemia type II; and craniolenticulosutural dysplasia. Is an ortholog of human SEC23B (SEC23 homolog B, COPII coat complex component). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0081003 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10702) | ||||
| DOID:0070307 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10701) | ||||||
| DOID:0111401 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10702) | ||||||
| Molecular_info | Corresponding_CDS | Y113G7A.3 | |||||||
| Corresponding_CDS_history | Y113G7A.3:wp47 | ||||||||
| Corresponding_transcript | Y113G7A.3.1 | ||||||||
| Other_sequence (54) | |||||||||
| Associated_feature (17) | |||||||||
| Experimental_info | RNAi_result (29) | ||||||||
| Expr_pattern | Expr2790 | ||||||||
| Expr1022212 | |||||||||
| Expr1032351 | |||||||||
| Expr1158901 | |||||||||
| Expr2015713 | |||||||||
| Expr2033945 | |||||||||
| Drives_construct | WBCnstr00004952 | ||||||||
| WBCnstr00010950 | |||||||||
| Construct_product | WBCnstr00010950 | ||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (122) | |||||||||
| Interaction (129) | |||||||||
| Anatomy_function | WBbtf0239 | ||||||||
| Map_info | Map | V | Position | 24.7157 | Error | 0.024791 | |||
| Positive | Positive_clone | Y113G7A | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4325 | |||||||
| 4800 | |||||||||
| 5484 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (17) | |||||||||
| Remark | Sequence connection from [Johnstone IL], [020809 krb] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
