WormBase Tree Display for Gene: WBGene00004754

WBGene00004754 SMap: S_parent: Sequence: Y113G7A
  Identity: Version: 1
    Name: CGC_name: sec-23 Person_evidence: WBPerson297
      Sequence_name: Y113G7A.3
      Molecular_name: Y113G7A.3
        Y113G7A.3.1
        CE27230
      Other_name: Y113G7A.n Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_Y113G7A.3 Accession_evidence: NDB BX284605
      Public_name: sec-23
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sec
    Allele (341)
    Strain: WBStrain00008607
    RNASeq_FPKM (74)
    GO_annotation (19)
    Ortholog: WBGene00063610 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00033782 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00164015 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00125061 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
      WBGene00228612 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g285 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g6185 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g3540 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g7309 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g1155 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g2287 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g6739 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g5996 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g21118 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g3802 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00740.g13810 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-sec-23 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g14754 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp11.Scaffold629.g14756 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_03640.g30833 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_03753.g31170 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_06440.g36539 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_19596 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_022020 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g11540 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g2678 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_50430000 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrV_pilon.g18023 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00181795 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00243420 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00098991 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00109987 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00256097 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00295351 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000006385 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0262125 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030131-5479 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040426-2823 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:10702 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:10701 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1349635 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1350925 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1309103 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1310699 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Structured_description: Concise_description: sec-23 encodes a component of COPII (coat protein complex II)-coated vesicles orthologous to Saccharomyces cerevisiae Sec23p; by homology, SEC-23 is predicted to be involved in endoplasmic reticulum (ER)-to-Golgi transport; loss of sec-23 activity results in defects in oogenesis, morphogenesis, and extracellular matrix secretion; a SEC-23::GFP fusion protein localizes to the apical region of the endoplasmic reticulum of hypodermal cells, consistent with localization to endoplasmic reticulum exit sites. Paper_evidence: WBPaper00006236
          Curator_confirmed: WBPerson1843
          Date_last_updated: 02 May 2014 00:00:00
      Automated_description: Predicted to enable GTPase activator activity. Predicted to be involved in COPII-coated vesicle cargo loading. Located in endoplasmic reticulum exit site. Expressed in hypodermis. Human ortholog(s) of this gene implicated in Cowden syndrome 7; congenital dyserythropoietic anemia type II; and craniolenticulosutural dysplasia. Is an ortholog of human SEC23B (SEC23 homolog B, COPII coat complex component). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0081003 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10702)
      DOID:0070307 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10701)
      DOID:0111401 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10702)
  Molecular_info: Corresponding_CDS: Y113G7A.3
    Corresponding_CDS_history: Y113G7A.3:wp47
    Corresponding_transcript: Y113G7A.3.1
    Other_sequence (54)
    Associated_feature (17)
  Experimental_info: RNAi_result (29)
    Expr_pattern: Expr2790
      Expr1022212
      Expr1032351
      Expr1158901
      Expr2015713
      Expr2033945
    Drives_construct: WBCnstr00004952
      WBCnstr00010950
    Construct_product: WBCnstr00010950
    Microarray_results (23)
    Expression_cluster (122)
    Interaction (129)
    Anatomy_function: WBbtf0239
  Map_info: Map: V Position: 24.7157 Error: 0.024791
    Positive: Positive_clone: Y113G7A Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4325
        4800
        5484
    Pseudo_map_position
  Reference (17)
  Remark: Sequence connection from [Johnstone IL], [020809 krb]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene