WormBase Tree Display for Gene: WBGene00004333
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| WBGene00004333 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | W02A2 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | rec-8 | Person_evidence | WBPerson533 | |||||
| Sequence_name | W02A2.6 | ||||||||
| Molecular_name | W02A2.6a | ||||||||
| W02A2.6a.1 | |||||||||
| CE21236 | |||||||||
| W02A2.6b | |||||||||
| CE45697 | |||||||||
| W02A2.6c | |||||||||
| CE45566 | |||||||||
| W02A2.6b.1 | |||||||||
| W02A2.6c.1 | |||||||||
| Other_name | CELE_W02A2.6 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | rec-8 | ||||||||
| DB_info | Database | AceView | gene | 4O114 | |||||
| WormQTL | gene | WBGene00004333 | |||||||
| WormFlux | gene | WBGene00004333 | |||||||
| NDB | locus_tag | CELE_W02A2.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004333|UniProtKB=Q9XUB3 | |||||||
| family | PTHR12585 | ||||||||
| NCBI | gene | 178295 | |||||||
| RefSeq | protein | NM_001268800.3 | |||||||
| NM_001268799.3 | |||||||||
| NM_001268798.3 | |||||||||
| SwissProt | UniProtAcc | Q9XUB3 | |||||||
| UniProt_GCRP | UniProtAcc | Q9XUB3 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:35 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | rec | ||||||||
| Allele (63) | |||||||||
| Legacy_information | RNAi phenotypes: >90% embryonic lethality, HIM (11% males); loss of meiotic chromosome pairing and sister chromatid cohesion; meiotic nondisjunction; protein localizes to axes of chromosomes at meiotic prophase | ||||||||
| Strain | WBStrain00035158 | ||||||||
| WBStrain00035162 | |||||||||
| WBStrain00035163 | |||||||||
| WBStrain00035963 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (34) | |||||||||
| Ortholog (19) | |||||||||
| Structured_description | Concise_description | rec-8 encodes a meiosis-specific cohesin complex subunit orthologous to Saccharomyces cerevisiae and Schizosaccharomyces pombe Rec8p; REC-8 is essential for pairing of homologoues and sister chromatids during meiosis and thus for proper chromosome disjunction; in the germline, REC-8 associates with chromatin of transition zone nuclei, and co-localizes with SMC-1 along the longitudinal axes of synapsed chromosomes at pachytene and in a cruciform pattern at diakinesis; REC-8 localization to chromatin is dependent upon TIM-1, a HEAT/Armadillo repeat-containing protein related to Drosophila TIMELESS, and additionally, REC-8 and SCC-3 are mutually required for chromatin localization; REC-8 cleavage and degradation during meiosis I is dependent on the AIR-2 aurora-like kinase and during meiosis II on AIR-2 and the PLK-1 polo-like kinase. | Paper_evidence | WBPaper00004722 | |||||
| WBPaper00004997 | |||||||||
| WBPaper00005919 | |||||||||
| WBPaper00006163 | |||||||||
| WBPaper00018756 | |||||||||
| WBPaper00019729 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable chromatin binding activity and damaged DNA binding activity. Involved in double-strand break repair and organelle organization. Located in nuclear lumen and spindle. Part of chromatin. Expressed in Z2; Z3; embryonic cell; and gonad. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | W02A2.6a | |||||||
| W02A2.6b | |||||||||
| W02A2.6c | |||||||||
| Corresponding_transcript | W02A2.6a.1 | ||||||||
| W02A2.6b.1 | |||||||||
| W02A2.6c.1 | |||||||||
| Other_sequence | CBC07473_1 | ||||||||
| CRC05866_1 | |||||||||
| CR05949 | |||||||||
| CJC04410_1 | |||||||||
| Associated_feature | WBsf668473 | ||||||||
| WBsf998389 | |||||||||
| WBsf1018520 | |||||||||
| WBsf231115 | |||||||||
| WBsf231116 | |||||||||
| Experimental_info | RNAi_result (25) | ||||||||
| Expr_pattern | Expr2451 | ||||||||
| Expr11542 | |||||||||
| Expr12238 | |||||||||
| Expr16473 | |||||||||
| Expr1017580 | |||||||||
| Expr1032151 | |||||||||
| Expr1158093 | |||||||||
| Expr2015291 | |||||||||
| Expr2033525 | |||||||||
| Drives_construct | WBCnstr00035561 | ||||||||
| Construct_product | WBCnstr00035561 | ||||||||
| Antibody (15) | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (125) | |||||||||
| Interaction (83) | |||||||||
| WBProcess | WBbiopr:00000099 | ||||||||
| Map_info | Map | IV | Position | 8.53422 | Error | 0.001584 | |||
| Positive | Positive_clone | W02A2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4298 | |||||||
| Pseudo_map_position | |||||||||
| Reference (75) | |||||||||
| Remark | [J. Loidl] rec-8 (W02A2.6) is the likely ortholog of S. cerevisiae rec8 meiosis-specific cohesion protein | ||||||||
| Sequence connection from [Loidl J] | |||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
