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WormBase Tree Display for Gene: WBGene00004333

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Name Class

WBGene00004333EvidenceCGC_data_submission
SMapS_parentSequenceW02A2
IdentityVersion1
NameCGC_namerec-8Person_evidenceWBPerson533
Sequence_nameW02A2.6
Molecular_nameW02A2.6a
W02A2.6a.1
CE21236
W02A2.6b
CE45697
W02A2.6c
CE45566
W02A2.6b.1
W02A2.6c.1
Other_nameCELE_W02A2.6Accession_evidenceNDBBX284604
Public_namerec-8
DB_infoDatabaseAceViewgene4O114
WormQTLgeneWBGene00004333
WormFluxgeneWBGene00004333
NDBlocus_tagCELE_W02A2.6
PanthergeneCAEEL|WormBase=WBGene00004333|UniProtKB=Q9XUB3
familyPTHR12585
NCBIgene178295
RefSeqproteinNM_001268800.3
NM_001268799.3
NM_001268798.3
SwissProtUniProtAccQ9XUB3
UniProt_GCRPUniProtAccQ9XUB3
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:35WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classrec
Allele (63)
Legacy_informationRNAi phenotypes: >90% embryonic lethality, HIM (11% males); loss of meiotic chromosome pairing and sister chromatid cohesion; meiotic nondisjunction; protein localizes to axes of chromosomes at meiotic prophase
StrainWBStrain00035158
WBStrain00035162
WBStrain00035163
WBStrain00035963
RNASeq_FPKM (74)
GO_annotation (34)
Ortholog (19)
Structured_descriptionConcise_descriptionrec-8 encodes a meiosis-specific cohesin complex subunit orthologous to Saccharomyces cerevisiae and Schizosaccharomyces pombe Rec8p; REC-8 is essential for pairing of homologoues and sister chromatids during meiosis and thus for proper chromosome disjunction; in the germline, REC-8 associates with chromatin of transition zone nuclei, and co-localizes with SMC-1 along the longitudinal axes of synapsed chromosomes at pachytene and in a cruciform pattern at diakinesis; REC-8 localization to chromatin is dependent upon TIM-1, a HEAT/Armadillo repeat-containing protein related to Drosophila TIMELESS, and additionally, REC-8 and SCC-3 are mutually required for chromatin localization; REC-8 cleavage and degradation during meiosis I is dependent on the AIR-2 aurora-like kinase and during meiosis II on AIR-2 and the PLK-1 polo-like kinase.Paper_evidenceWBPaper00004722
WBPaper00004997
WBPaper00005919
WBPaper00006163
WBPaper00018756
WBPaper00019729
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to enable chromatin binding activity and damaged DNA binding activity. Involved in double-strand break repair and organelle organization. Located in nuclear lumen and spindle. Part of chromatin. Expressed in Z2; Z3; embryonic cell; and gonad.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSW02A2.6a
W02A2.6b
W02A2.6c
Corresponding_transcriptW02A2.6a.1
W02A2.6b.1
W02A2.6c.1
Other_sequenceCBC07473_1
CRC05866_1
CR05949
CJC04410_1
Associated_featureWBsf668473
WBsf998389
WBsf1018520
WBsf231115
WBsf231116
Experimental_infoRNAi_result (25)
Expr_patternExpr2451
Expr11542
Expr12238
Expr16473
Expr1017580
Expr1032151
Expr1158093
Expr2015291
Expr2033525
Drives_constructWBCnstr00035561
Construct_productWBCnstr00035561
Antibody (15)
Microarray_results (21)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00032031:DConiospora_upregulated_cDNA_24h
WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:AVE-neuron_L1-larva_expressed
WBPaper00037950:bodywall-muscle_L1-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:germline-precursors_embryo_enriched
WBPaper00037950:hypodermis_embryo_enriched
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:pharyngeal-muscle_embryo_enriched
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00038168:lin-15B(n744)_upregulated
WBPaper00038168:lin-35_upregulated
WBPaper00040560:hpl-2_L3_upregulated
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00044786:emr-1(gk119)_downregulated
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Gender_Neutral
WBPaper00045571:germline-ablation_downregulated
WBPaper00048611:MnCl2_downregulated
WBPaper00048988:neuron_expressed
WBPaper00049498:npr-1(ur89)_regulated_8
WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050080:rbr-2(tm3141)_downregulated
WBPaper00050193:lsm-1(tm3585)_upregulated_L3
WBPaper00050193:met-2(n4256)set-25(n5021)_upregulated_L1
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050522:mafr-1(tm6082)_downregulated
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:starvation_regulated_LowSalt
WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050990:hypodermis_enriched
WBPaper00050990:hypodermis_expressed
WBPaper00051039:germline_enriched
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053302:alovudine_24h_regulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053321:PGCs_enriched_NuGen
WBPaper00053388:dauer_regulated_Cluster2
WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
WBPaper00053810:nuo-6(qm200)_downregulated
WBPaper00053814:25C_upregulated_OP50
WBPaper00055334:DLC-1_interacting
WBPaper00055354:Rapamycin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin_downregulated
WBPaper00055354:Rifampicin_downregulated
WBPaper00055648:germline_expressed
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00055971:nhl-2(ok818)_25C_upregulated
WBPaper00056139:soil-microbiota_downregulated
WBPaper00056165:MINA-1_interacting_mRNA
WBPaper00056443:sek-1(km4)_downregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00056826:hmc_biased
WBPaper00057288:Cold_upregulated_transcript
WBPaper00057288:iff-1(RNAi)_upregulated_transcript
WBPaper00058598:sin-3(tm1276)_upregulated
WBPaper00058691:cfp-1(tm6369)_upregulated
WBPaper00058691:sin-3(tm1276)_upregulated
WBPaper00058725:sftb-1(cer39)_downregulated
WBPaper00059027:neuron-synapses_enriched
WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated
WBPaper00059664:srbc-48(ac23)_downregulated
WBPaper00059739:hira-1(gk835598)_upregulated_L1
WBPaper00060445:ikb-1(nr2027)_upregulated_L4
WBPaper00060445:nfki-1(cer1)_upregulated_L4
WBPaper00060459:bcat-1(RNAi)_downregulated
WBPaper00060661:sensory-neuron_depleted
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00060871:M.humicola-infection_48h_regulated
WBPaper00060909:atfs-1(cmh15)_upregulated
WBPaper00060911:prx-5(RNAi)_downregulated_protein
WBPaper00061203:sin-3(tm1276)_downregulated
WBPaper00061340:Germline
WBPaper00061466:nath-10(icb99)_upregulated
WBPaper00061466:nath-10(icb102)_upregulated
WBPaper00061527:puf-3-oma-2_18268
WBPaper00061753:csr-1(tor159)_downregulated_25C
WBPaper00062159:hda-2(ok1479)_downregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00063924:PARG-1_interacting
WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064716:paraquat_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065258:anchor-cell_depleted
WBPaper00065373:Cisplatin_upregulated_WT
WBPaper00065373:sek-1(km4)_upregulated_Ref
WBPaper00065746:eat-2(ad1113)_downregulated
WBPaper00065984:pals-17(syb3980)_upregulated
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066110:tetraploid_vs_diploid_downregulated
cgc4489_group_9
WBPaper00032062:age_regulated_genes
WBPaper00032165:A_to_C_transit_decreased
WBPaper00035905:FBF-1_Associated
WBPaper00036123:Atrazine_regulated
WBPaper00036286:Pattern_B
WBPaper00041002:HF_11d_2.0mM_Up
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00042331:a-SWCNTs_downregulated
WBPaper00045263:nuo-6(qm200)_downregulated
WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
WBPaper00056330:mrps-5(RNAi)_downregulated
[cgc5767]:expression_class_M
[cgc5767]:expression_class_SM
[cgc6390]:Cluster_F
[cgc6390]:intrinsic
Interaction (83)
WBProcessWBbiopr:00000099
Map_infoMapIVPosition8.53422Error0.001584
PositivePositive_cloneW02A2Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4298
Pseudo_map_position
Reference (75)
Remark[J. Loidl] rec-8 (W02A2.6) is the likely ortholog of S. cerevisiae rec8 meiosis-specific cohesion protein
Sequence connection from [Loidl J]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene