WormBase Tree Display for Gene: WBGene00004271

WBGene00004271 SMap: S_parent: Sequence: W03C9
  Identity: Version: 1
    Name: CGC_name: rab-7 Person_evidence: WBPerson451
      Sequence_name: W03C9.3
      Molecular_name: W03C9.3
        W03C9.3.1
        CE03777
      Other_name: CELE_W03C9.3 Accession_evidence: NDB BX284602
      Public_name: rab-7
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info (11)
  Disease_info: Experimental_model: DOID:9970 Homo sapiens Paper_evidence: WBPaper00030935
          Accession_evidence: OMIM 601665
          Curator_confirmed: WBPerson324
          Date_last_updated: 30 Jan 2013 00:00:00
    Potential_model: DOID:0110159 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9788)
    Disease_relevance: Studies in C. elegans suggest that the small Rab GTPase RAB-7 and the Rab-GTPase-activating protein RBG-3 are involved in a tub-1/tubby mediated endocytic pathway that increases fat storage; tub-1/tubby is a gene involved in obesity across species; tub-1 also interacts with RBG-3 in ciliated neurons to possibly modulate neurohormonal and chemosensory function in the regulation of fat storage. Homo sapiens Paper_evidence: WBPaper00031329
            WBPaper00038404
          Accession_evidence: OMIM 203750
              601665
          Curator_confirmed: WBPerson324
          Date_last_updated: 12 Jan 2012 00:00:00
  Models_disease_in_annotation: WBDOannot00000028
  Molecular_info: Corresponding_CDS: W03C9.3
    Corresponding_transcript: W03C9.3.1
    Other_sequence (45)
    Associated_feature: WBsf650634
      WBsf666217
      WBsf224016
      WBsf224017
  Experimental_info: RNAi_result (75)
    Expr_pattern (11)
    Drives_construct: WBCnstr00012363
      WBCnstr00020664
      WBCnstr00042405
    Construct_product (36)
    Antibody: WBAntibody00001207
      WBAntibody00002256
    Microarray_results (21)
    Expression_cluster: WBPaper00032031:DConiospora_downregulated_OligoArray_24h
      WBPaper00035073:mitochondria_protein
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00038289:oocyte_protein
      WBPaper00040285:H2S_24hr_upregulated
      WBPaper00040965:lipid-droplet_associated_protein
      WBPaper00044128:DietaryRestriction_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Oogenic
      WBPaper00046012:tdp-1(ok803)_downregulated
      WBPaper00046509:htz-1(ok3099)_upregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00050182:lmn-1(L535P)_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
      WBPaper00053814:25C_downregulated_PY79
      WBPaper00054410:set-26(tm2467)_downregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00057288:Cold_upregulated_transcript
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:Intestinal_and_rectal_muscle
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:T23B5.3_15993-C17D12.1
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064107:lin-35(n745)_downregulated
      WBPaper00064201:SNA-3_interacting
      WBPaper00064716:paraquat_upregulated
      WBPaper00064992:Eugenol_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00027111:eri-1(mg366)_upregulated
      WBPaper00031832:slr-2_regulated
      WBPaper00034739:N2lessDR1350
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Cadmium_regulated
      WBPaper00037611:RNP-8-associated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040821:Au-NP_regulated
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_prime
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-exposed_24h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00044535:male_upregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00055899:nitroguanidine_regulated
      [cgc6390]:mixed_oogenesis-somatic
    Interaction (96)
    WBProcess: WBbiopr:00000015
  Map_info: Map: II Position: 4.64486 Error: 0.24308
    Positive: Positive_clone: W03C9 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4619
    Pseudo_map_position
  Reference (132)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene