WormBase Tree Display for Gene: WBGene00004202
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| WBGene00004202 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C37A5 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | pry-1 | Person_evidence | WBPerson1157 | |||||
| Sequence_name | C37A5.9 | ||||||||
| Molecular_name | C37A5.9 | ||||||||
| C37A5.9.1 | |||||||||
| CE30125 | |||||||||
| Other_name | Axin | Paper_evidence | WBPaper00044307 | ||||||
| CELE_C37A5.9 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | pry-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pry | ||||||||
| Allele (164) | |||||||||
| Possibly_affected_by | WBVar02153203 | ||||||||
| Legacy_information | [Maloof JN] pry for polyray. Adult males make no alae but instead have ectopic rays. Hermaphrodites are sometimes Muv. The descendants of QR stay in the posterior. The postderid is often missing. Causes late ectopic expression of lin-39, mab-5, and egl-5. | ||||||||
| [C.elegansII] mu38 : adult males make no alae but instead have ectopic rays. Hermaphrodites are sometimes Muv. The descendants of QR stay in the posterior. The postderid is often missing. Causes late ectopic expression of lin-39, mab-5, and egl-5. See also spy. [CF] | |||||||||
| Strain | WBStrain00023614 | ||||||||
| WBStrain00030966 | |||||||||
| WBStrain00004827 | |||||||||
| WBStrain00024333 | |||||||||
| WBStrain00047536 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (59) | |||||||||
| Ortholog (35) | |||||||||
| Structured_description | Concise_description | pry-1 encodes a protein containing RGS and DIX domains that is distantly related to members of the Axin family of proteins that function as part of a complex that targets beta-catenin for destruction in the absence of Wnt signaling; during C. elegans development, PRY-1 functions as a negative regulator of Wnt signaling pathways that specify cell fates during asymmetric cell division; in addition, pry-1 has been shown to have a role in axon guidance; PRY-1 physically interacts with BAR-1, SGG-1, APR-1, and AXL-1; PRY-1 reporter fusion proteins are expressed in hypodermal and neuronal lineages where they typically localize asymmetrically to the anterior cortex. | Paper_evidence | WBPaper00003383 | |||||
| WBPaper00005278 | |||||||||
| WBPaper00028984 | |||||||||
| WBPaper00029082 | |||||||||
| WBPaper00030820 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 02 Feb 2009 00:00:00 | ||||||||
| Automated_description | Enables ubiquitin ligase-substrate adaptor activity. Involved in several processes, including axon guidance; negative regulation of vulval development; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cell cortex; membrane; and nucleus. Part of beta-catenin destruction complex. Expressed in several structures, including QL.a; hypodermal cell; neurons; ventral cord blast cell; and vulval precursor cell. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C37A5.9 | |||||||
| Corresponding_CDS_history | C37A5.9:wp71 | ||||||||
| Corresponding_transcript | C37A5.9.1 | ||||||||
| Other_sequence (14) | |||||||||
| Associated_feature | WBsf665111 | ||||||||
| WBsf986083 | |||||||||
| WBsf1011197 | |||||||||
| WBsf220586 | |||||||||
| WBsf220587 | |||||||||
| WBsf220588 | |||||||||
| Experimental_info | RNAi_result (63) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00000302 | ||||||||
| WBCnstr00000614 | |||||||||
| WBCnstr00012109 | |||||||||
| WBCnstr00016100 | |||||||||
| WBCnstr00019338 | |||||||||
| WBCnstr00022520 | |||||||||
| WBCnstr00042081 | |||||||||
| WBCnstr00042220 | |||||||||
| Construct_product | WBCnstr00012109 | ||||||||
| WBCnstr00016100 | |||||||||
| WBCnstr00042081 | |||||||||
| WBCnstr00042082 | |||||||||
| WBCnstr00042083 | |||||||||
| WBCnstr00042084 | |||||||||
| WBCnstr00042220 | |||||||||
| Regulate_expr_cluster | WBPaper00055626:pry-1(mu38)_downregulated | ||||||||
| WBPaper00055626:pry-1(mu38)_upregulated | |||||||||
| WBPaper00057033:pry-1(mu38)_downregulated | |||||||||
| WBPaper00057033:pry-1(mu38)_upregulated | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (107) | |||||||||
| Interaction (191) | |||||||||
| Map_info | Map | I | Position | 23.6118 | Error | 0.064259 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C37A5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 3241 | |||||||
| 3242 | |||||||||
| 4451 | |||||||||
| 4793 | |||||||||
| Pos_neg_data | 8537 | ||||||||
| Reference (88) | |||||||||
| Picture | WBPicture0000013083 | ||||||||
| Remark | Sequence connection from [Korswagen H] | ||||||||
| Method | Gene |
