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WormBase Tree Display for Gene: WBGene00004077

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Name Class

WBGene00004077EvidenceCGC_data_submission
SMapS_parentSequenceCHROMOSOME_I
IdentityVersion1
NameCGC_namepop-1Person_evidenceWBPerson498
Sequence_nameW10C8.2
Molecular_nameW10C8.2
W10C8.2.1
CE46967
Other_namesys-2
CELE_W10C8.2Accession_evidenceNDBBX284601
Public_namepop-1
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:34WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classpop
Allele (168)
Legacy_information[Lin R] Pop (posterior pharynx defective) phenotype: maternal lethal, causing MS blastomere to adopt the fate of sister blastomere E; resulting embryos have twice the wildtype amount of gut. zu189 isolated in mutator background, probable Tc1 insertion.
[C.elegansII] zu189mut : maternal effect embryonic lethal,no MS-derived pharyngeal cells; MS blastomere adopts the fate of sister blastomere E; resulting embryos have twice the wildtype amount of gut. NA1. Cloned: encodes predicted 487 aa protein with HMG box; antibody stains nuclei of oocytes, early blastomeres. [Lin et al. 1995; JJ]
Strain (11)
RNASeq_FPKM (74)
GO_annotation (113)
Ortholog (59)
Structured_descriptionConcise_descriptionpop-1 encodes an HMG box-containing protein that is the sole C. elegans member of the TCF/LEF family of transcription factors; in C. elegans, POP-1 functions as a component of the canonical and noncanonical Wnt signaling pathways that are required for cell migrations and binary cell fate decisions associated with asymmetric cell division, respectively; in yeast two-hybrid assays, the POP-1 N-terminal beta-catenin binding domain interacts with BAR-1/beta-catenin as well as with the more divergent beta-catenin, SYS-1; when coexpressed with SYS-1, POP-1 is able to activate transcription from a promoter with TCF binding sites; during development, maternally provided POP-1 is first detected in the nuclei of maturing oocytes and then in nearly all cells of the early embryo; in sister blastomeres in the early embryo, POP-1 is detected at lower levels in posterior blastomeres, such as E and P3, than in corresponding anterior blastomeres, MS and C; in later developmental stages, POP-1 is detected in a subset of tissues including hypodermal seam cells, gonadal precursors, and the developing vulva; in the vulva, POP-1 also exhibits an asymmetric staining pattern, with sister cells showing high or low levels of POP-1 depending upon their orientation along the anterior/posterior axis of the vulva.Paper_evidenceWBPaper00002330
WBPaper00004103
WBPaper00005116
WBPaper00024693
WBPaper00026603
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated04 Aug 2005 00:00:00
Automated_descriptionEnables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; beta-catenin binding activity; and enzyme binding activity. Involved in several processes, including mesodermal cell fate commitment; regulation of cell division; and regulation of gene expression. Located in cytoplasm and nucleus. Expressed in several structures, including ABplpapaaa; ABprpapaaa; oocyte; somatic nervous system; and vulva. Used to study obesity. Human ortholog(s) of this gene implicated in several diseases, including diabetes mellitus (multiple); endocrine gland cancer (multiple); and prostate disease (multiple). Is an ortholog of human TCF7L2 (transcription factor 7 like 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:9970Homo sapiensPaper_evidenceWBPaper00061889
Curator_confirmedWBPerson324
Date_last_updated28 Jun 2022 00:00:00
Potential_modelDOID:9351Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11641)
DOID:9256Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11641)
DOID:9352Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11641)
DOID:11714Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11641)
DOID:2394Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6551)
DOID:3969Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6551)
DOID:8634Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6551)
DOID:10283Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11639,HGNC:11641,HGNC:6551)
DOID:1793Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11641)
DOID:1612Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11641)
Models_disease_in_annotationWBDOannot00001266
Molecular_infoCorresponding_CDSW10C8.2
Corresponding_CDS_historyW10C8.2:wp229
Corresponding_transcriptW10C8.2.1
Other_sequence (26)
Associated_feature (14)
Gene_product_binds (20)
Transcription_factorWBTranscriptionFactor000102
Experimental_infoRNAi_result (249)
Expr_pattern (15)
Drives_constructWBCnstr00001895
WBCnstr00012848
WBCnstr00035711
Construct_product (13)
AntibodyWBAntibody00000100
WBAntibody00000162
WBAntibody00000612
WBAntibody00000723
WBAntibody00000724
Microarray_results (22)
Expression_cluster (116)
Interaction (464)
Anatomy_functionWBbtf0106
WBProcessWBbiopr:00000073
WBbiopr:00000112
WBbiopr:00000114
Map_infoMapIPosition-5.32204Error0.039261
Well_ordered
PositivePositive_cloneBF8
W10C8Inferred_automaticallyFrom sequence, transcript, pseudogene data
NegativeNegative_cloneK11A2
Mapping_data2_point7005
7006
Multi_point3030
4915
5051
Pos_neg_data8160
8161
8162
8163
8164
8165
10668
10669
ReferenceWBPaper00002330
WBPaper00002531
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WBPaper00002734
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WBPaper00010125
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WBPaper00010231
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WBPaper00010990
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WBPaper00019754
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WBPaper00021917
WBPaper00022368
WBPaper00022501
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WBPaper00022879
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WBPaper00023031
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PictureWBPicture0000013083
WBPicture0000013084
Remark (4)
MethodGene