WormBase Tree Display for Gene: WBGene00004053
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WBGene00004053 | SMap | S_parent | Sequence | CHROMOSOME_V | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | tank-1 | Person_evidence | WBPerson236 | |||
Sequence_name | ZK1005.1 | ||||||
Molecular_name | ZK1005.1a | ||||||
ZK1005.1a.1 | |||||||
CE24712 | |||||||
ZK1005.1b | |||||||
CE33259 | |||||||
ZK1005.1b.1 | |||||||
Other_name | pme-5 | ||||||
CELE_ZK1005.1 | Accession_evidence | NDB | BX284605 | ||||
Public_name | tank-1 | ||||||
DB_info | Database (12) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | tank | ||||||
Allele (183) | |||||||
Strain | WBStrain00031422 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (20) | |||||||
Ortholog (29) | |||||||
Paralog | WBGene00004049 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
WBGene00004050 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | tank-1 (formerly known as pme-5) encodes a protein containing N-terminal ankyrin repeats and C-terminal poly (ADP-ribose) polymerase (PARP) regulatory and catalytic domains that is orthologous to human tankyrase 1 (TNKS; OMIM:603303) and tankyrase 2 (TNKS2; OMIM: 607128), but structurally more similar to the ADPRT-3 tankyrase of Dictyostelium discoideum; TANK-1 also contains a lysine-rich region, a WGR domain, which may mediate DNA interaction, and a coil-coiled region; X-ray-induced apoptosis of germ cells is slightly increased in tank-1(RNAi) animals; DNA damage via ionizing radiation induces tank-1 expression, and this induction absolutely requires HUS-1; TANK-1 is ubiquitously expressed throughout the life cycle, including in the germ line, and localizes to the nucleus. | Paper_evidence | WBPaper00005600 | |||
WBPaper00006357 | |||||||
WBPaper00032454 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 14 Nov 2014 00:00:00 | ||||||
Automated_description | Predicted to enable NAD+ ADP-ribosyltransferase activity and NAD+-protein ADP-ribosyltransferase activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of programmed cell death; and response to gamma radiation. Located in nucleus. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | ZK1005.1a | |||||
ZK1005.1b | |||||||
Corresponding_transcript | ZK1005.1a.1 | ||||||
ZK1005.1b.1 | |||||||
Other_sequence | Oden_isotig21192 | ||||||
JI163989.1 | |||||||
DN190409.1 | |||||||
Hbac_isotig06157 | |||||||
CRC03985_1 | |||||||
CJC00359_1 | |||||||
AAC00581_1 | |||||||
CR12145 | |||||||
CBC08961_1 | |||||||
Dviv_isotig23950 | |||||||
Associated_feature | WBsf652468 | ||||||
WBsf999295 | |||||||
WBsf999296 | |||||||
WBsf1019159 | |||||||
WBsf233325 | |||||||
WBsf233326 | |||||||
Experimental_info | RNAi_result | WBRNAi00098031 | Inferred_automatically | RNAi_primary | |||
WBRNAi00059031 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00061225 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00098001 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00021767 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00021435 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr8972 | ||||||
Expr11816 | |||||||
Expr1028040 | |||||||
Expr1031952 | |||||||
Expr1162461 | |||||||
Expr2017296 | |||||||
Expr2035431 | |||||||
Drives_construct | WBCnstr00037943 | ||||||
Construct_product | WBCnstr00037943 | ||||||
Antibody | WBAntibody00001710 | ||||||
WBAntibody00001711 | |||||||
Microarray_results (24) | |||||||
Expression_cluster (193) | |||||||
Interaction (24) | |||||||
Map_info | Map | V | Position | -19.844 | Error | 0.004452 | |
Positive | Positive_clone | ZK1005 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 4593 | |||||
Pseudo_map_position | |||||||
Reference (11) | |||||||
Remark | Sequence connection via email from [Desnoyers S], [krb 020729] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |