WormBase Tree Display for Gene: WBGene00004053

WBGene00004053 SMap: S_parent: Sequence: CHROMOSOME_V
  Identity: Version: 2
    Name: CGC_name: tank-1 Person_evidence: WBPerson236
      Sequence_name: ZK1005.1
      Molecular_name: ZK1005.1a
        ZK1005.1a.1
        CE24712
        ZK1005.1b
        CE33259
        ZK1005.1b.1
      Other_name: pme-5
        CELE_ZK1005.1 Accession_evidence: NDB BX284605
      Public_name: tank-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 18 Nov 2014 11:51:19 WBPerson2970 Name_change: CGC_name: tank-1
                Other_name: pme-5
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: tank
    Allele: WBVar01500253
      WBVar00257078
      WBVar01833793
      WBVar01833794
      WBVar01833795
      WBVar01833796
      WBVar01833797
      WBVar01499528
      WBVar01833798
      WBVar01833799
      WBVar00985290
      WBVar00202667
      WBVar00985291
      WBVar00202668
      WBVar00985292
      WBVar00202669
      WBVar00985293
      WBVar00202670
      WBVar01499167
      WBVar00202671
      WBVar00985294
      WBVar00202672
      WBVar00985295
      WBVar00202673
      WBVar00985296
      WBVar00985297
      WBVar00202674
      WBVar00985298
      WBVar00202675
      WBVar00985299
      WBVar00202676
      WBVar00202677
      WBVar00985300
      WBVar00580957
      WBVar00985301
      WBVar00202678
      WBVar00202679
      WBVar00985302
      WBVar02031772
      WBVar00985303
      WBVar00985304
      WBVar00985305
      WBVar00985306
      WBVar00985307
      WBVar00985308
      WBVar00985309
      WBVar00985310
      WBVar00985311
      WBVar01584536
      WBVar00985312
      WBVar00985313
      WBVar01499740
      WBVar00985314
      WBVar00985315
      WBVar00985316
      WBVar00985317
      WBVar00985318
      WBVar00985319
      WBVar00985320
      WBVar00985321
      WBVar00985322
      WBVar00985323
      WBVar00251591
      WBVar00985324
      WBVar00985325
      WBVar00985326
      WBVar00985327
      WBVar00985328
      WBVar00449690
      WBVar00449691
      WBVar00985329
      WBVar00449692
      WBVar00985330
      WBVar00271429
      WBVar00449693
      WBVar00985331
      WBVar00985332
      WBVar00449694
      WBVar00985333
      WBVar00449695
      WBVar00985334
      WBVar00449696
      WBVar00985335
      WBVar00449697
      WBVar00449698
      WBVar00985336
      WBVar00985337
      WBVar00449699
      WBVar00449700
      WBVar00985338
      WBVar00449701
      WBVar00985339
      WBVar00449702
      WBVar00985340
      WBVar00449703
      WBVar00985341
      WBVar00985342
      WBVar00449704
      WBVar00449705
      WBVar00985343
      WBVar00985344
      WBVar00449706
      WBVar00449707
      WBVar00985345
      WBVar00985346
      WBVar00449708
      WBVar00449709
      WBVar00985347
      WBVar00449710
      WBVar00985348
      WBVar00985349
      WBVar00449711
      WBVar00985350
      WBVar00449712
      WBVar00985351
      WBVar00449713
      WBVar00985352
      WBVar00449714
      WBVar01661153
      WBVar00449715
      WBVar00985353
      WBVar00449716
      WBVar01985371
      WBVar00985354
      WBVar00449717
      WBVar01985372
      WBVar00985355
      WBVar00985356
      WBVar01985373
      WBVar00449718
      WBVar00985357
      WBVar00449719
      WBVar01985374
      WBVar01499784
      WBVar00985358
      WBVar00449720
      WBVar01985375
      WBVar01985376
      WBVar00449721
      WBVar00985359
      WBVar00985360
      WBVar00985361
      WBVar00985362
      WBVar00985363
      WBVar01496844
      WBVar00985364
      WBVar00985365
      WBVar00985366
      WBVar01703051
      WBVar01703052
      WBVar01610271
      WBVar01610272
      WBVar01610273
      WBVar01457998
      WBVar01610274
      WBVar01457999
      WBVar01774794
      WBVar01458000
      WBVar01610275
      WBVar01774795
      WBVar01610276
      WBVar01610277
      WBVar01610278
      WBVar01610279
      WBVar01610280
      WBVar01610281
      WBVar01610282
      WBVar01610283
      WBVar01610284
      WBVar01610285
      WBVar01610286
      WBVar01610287
      WBVar01807482
      WBVar00091737
      WBVar01970916
      WBVar01970917
      WBVar01970918
      WBVar02092789
      WBVar01499496
      WBVar02090411
      WBVar01674163
      WBVar01674164
      WBVar01500066
    Strain: WBStrain00031422
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (29)
    Paralog: WBGene00004049 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004050 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: tank-1 (formerly known as pme-5) encodes a protein containing N-terminal ankyrin repeats and C-terminal poly (ADP-ribose) polymerase (PARP) regulatory and catalytic domains that is orthologous to human tankyrase 1 (TNKS; OMIM:603303) and tankyrase 2 (TNKS2; OMIM: 607128), but structurally more similar to the ADPRT-3 tankyrase of Dictyostelium discoideum; TANK-1 also contains a lysine-rich region, a WGR domain, which may mediate DNA interaction, and a coil-coiled region; X-ray-induced apoptosis of germ cells is slightly increased in tank-1(RNAi) animals; DNA damage via ionizing radiation induces tank-1 expression, and this induction absolutely requires HUS-1; TANK-1 is ubiquitously expressed throughout the life cycle, including in the germ line, and localizes to the nucleus. Paper_evidence: WBPaper00005600
            WBPaper00006357
            WBPaper00032454
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 14 Nov 2014 00:00:00
      Automated_description: Predicted to enable NAD+ ADP-ribosyltransferase activity and NAD+-protein ADP-ribosyltransferase activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of programmed cell death; and response to gamma radiation. Located in nucleus. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: ZK1005.1a
      ZK1005.1b
    Corresponding_transcript: ZK1005.1a.1
      ZK1005.1b.1
    Other_sequence: Oden_isotig21192
      JI163989.1
      DN190409.1
      Hbac_isotig06157
      CRC03985_1
      CJC00359_1
      AAC00581_1
      CR12145
      CBC08961_1
      Dviv_isotig23950
    Associated_feature: WBsf652468
      WBsf999295
      WBsf999296
      WBsf1019159
      WBsf233325
      WBsf233326
  Experimental_info: RNAi_result: WBRNAi00098031 Inferred_automatically: RNAi_primary
      WBRNAi00059031 Inferred_automatically: RNAi_primary
      WBRNAi00061225 Inferred_automatically: RNAi_primary
      WBRNAi00098001 Inferred_automatically: RNAi_primary
      WBRNAi00021767 Inferred_automatically: RNAi_primary
      WBRNAi00021435 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr8972
      Expr11816
      Expr1028040
      Expr1031952
      Expr1162461
      Expr2017296
      Expr2035431
    Drives_construct: WBCnstr00037943
    Construct_product: WBCnstr00037943
    Antibody: WBAntibody00001710
      WBAntibody00001711
    Microarray_results (24)
    Expression_cluster (193)
    Interaction (24)
  Map_info: Map: V Position: -19.844 Error: 0.004452
    Positive: Positive_clone: ZK1005 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4593
    Pseudo_map_position
  Reference (11)
  Remark: Sequence connection via email from [Desnoyers S], [krb 020729]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene