WormBase Tree Display for Gene: WBGene00004014
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WBGene00004014 | SMap | S_parent | Sequence | Y37E3 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | phb-1 | Person_evidence | WBPerson364 | |||||
Sequence_name | Y37E3.9 | ||||||||
Molecular_name | Y37E3.9 | ||||||||
Y37E3.9.1 | |||||||||
CE26775 | |||||||||
Other_name | CELE_Y37E3.9 | Accession_evidence | NDB | BX284601 | |||||
Public_name | phb-1 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | phb | ||||||||
Allele (26) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (19) | |||||||||
Contained_in_operon | CEOP1036 | ||||||||
Ortholog (37) | |||||||||
Paralog | WBGene00004015 | Caenorhabditis elegans | From_analysis (2) | ||||||
Structured_description | Concise_description | phb-1 encodes the C. elegans ortholog of prohibitin PHB1; loss of phb-1 activity via RNAi indicates that phb-1 function is required for mitochondrial organization and morphology and for embryonic, germline, and somatic gonad development; PHB-1, along with prohibitin subunit PHB-2, forms a macromolecular complex that localizes to mitochondrial membranes; PHB-1 and PHB-2 are dependent upon one another for stability: loss of either phb-1 or phb-2 activity via RNAi results in depletion of both protein products. | Paper_evidence | WBPaper00006039 | |||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 20 Dec 2010 00:00:00 | ||||||||
Automated_description | Involved in several processes, including defecation; developmental process involved in reproduction; and mitochondrion morphogenesis. Located in mitochondrial membrane. Part of mitochondrial prohibitin complex. Expressed in several structures, including body wall musculature; excretory canal; hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including cervix uteri carcinoma in situ; prostate carcinoma in situ; and sporadic breast cancer. Is an ortholog of human PHB1 (prohibitin 1). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:8991 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8912) | ||||
DOID:8634 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8912) | ||||||
DOID:2671 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8912) | ||||||
DOID:8029 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8912) | ||||||
DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8912) | ||||||
Molecular_info | Corresponding_CDS | Y37E3.9 | |||||||
Corresponding_transcript | Y37E3.9.1 | ||||||||
Other_sequence (132) | |||||||||
Associated_feature | WBsf654771 | ||||||||
WBsf656007 | |||||||||
WBsf980953 | |||||||||
WBsf217273 | |||||||||
Experimental_info | RNAi_result (121) | ||||||||
Expr_pattern | Expr8823 | ||||||||
Expr1014089 | |||||||||
Expr1031921 | |||||||||
Expr1159459 | |||||||||
Expr2014888 | |||||||||
Expr2033123 | |||||||||
Drives_construct | WBCnstr00013545 | ||||||||
Construct_product | WBCnstr00013545 | ||||||||
Microarray_results (17) | |||||||||
Expression_cluster (150) | |||||||||
Interaction (139) | |||||||||
Map_info | Map | I | Position | -11.8948 | Error | 0.038996 | |||
Positive | Positive_clone | Y37E3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference (16) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |