phb-1 encodes the C. elegans ortholog of prohibitin PHB1; loss of phb-1 activity via RNAi indicates that phb-1 function is required for mitochondrial organization and morphology and for embryonic, germline, and somatic gonad development; PHB-1, along with prohibitin subunit PHB-2, forms a macromolecular complex that localizes to mitochondrial membranes; PHB-1 and PHB-2 are dependent upon one another for stability: loss of either phb-1 or phb-2 activity via RNAi results in depletion of both protein products.
Involved in several processes, including defecation; developmental process involved in reproduction; and mitochondrion morphogenesis. Located in mitochondrial membrane. Part of mitochondrial prohibitin complex. Expressed in several structures, including body wall musculature; excretory canal; hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including cervix uteri carcinoma in situ; prostate carcinoma in situ; and sporadic breast cancer. Is an ortholog of human PHB1 (prohibitin 1).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.