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WormBase Tree Display for Gene: WBGene00004001

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Name Class

WBGene00004001SMapS_parentSequenceT21E8
IdentityVersion1
NameCGC_namepgp-7Person_evidenceWBPerson490
Sequence_nameT21E8.2
Molecular_nameT21E8.2
T21E8.2.1
CE53605
Other_nameCELE_T21E8.2Accession_evidenceNDBBX284606
Public_namepgp-7
DB_infoDatabaseAceViewgeneXL484
WormQTLgeneWBGene00004001
WormFluxgeneWBGene00004001
NDBlocus_tagCELE_T21E8.2
PanthergeneCAEEL|WormBase=WBGene00004001|UniProtKB=Q22655
familyPTHR24221
NCBIgene188697
RefSeqproteinNM_001375126.1
TrEMBLUniProtAccQ22655
UniProt_GCRPUniProtAccQ22655
OMIMgene171050
171060
603201
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:33WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classpgp
Allele (39)
StrainWBStrain00001119
WBStrain00031754
WBStrain00035647
RNASeq_FPKM (74)
GO_annotation (13)
Ortholog (57)
Paralog (23)
Structured_descriptionConcise_descriptionpgp-7 encodes an ATP-binding protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; PGP-7 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of pgp-7 activity via RNAi results in no obvious defects, the precise role of PGP-7 in C. elegans development and/or behavior is not yet known; pgp-7 promoter-gfp fusion proteins are expressed in the rays of the adult male tail.Paper_evidenceWBPaper00006421
WBPaper00024561
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated07 Mar 2006 00:00:00
Automated_descriptionPredicted to enable ATPase-coupled transmembrane transporter activity. Involved in stress response to cadmium ion. Predicted to be located in membrane. Expressed in tail. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and intrahepatic cholestasis (multiple). Is an ortholog of several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB11 (ATP binding cassette subfamily B member 11); and ABCB4 (ATP binding cassette subfamily B member 4).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (41)
Molecular_infoCorresponding_CDST21E8.2
Corresponding_CDS_historyT21E8.2:wp124
T21E8.2:wp272
Corresponding_transcriptT21E8.2.1
Other_sequenceDviv_isotig27005
Associated_featureWBsf1006841
Experimental_infoRNAi_resultWBRNAi00018983Inferred_automaticallyRNAi_primary
WBRNAi00053749Inferred_automaticallyRNAi_primary
Expr_patternExpr3331
Expr3332
Expr6734
Expr1157297
Expr2014874
Expr2033109
Drives_constructWBCnstr00002003
WBCnstr00011327
WBCnstr00011328
WBCnstr00035749
Construct_productWBCnstr00035749
Microarray_results (15)
Expression_clusterWBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00033065:isp-1-1(qm150)_downregulated
WBPaper00037682:sma-2_upregulated
WBPaper00037950:AVA-neuron_embryo_enriched
WBPaper00037950:AVA-neuron_embryo_SelectivelyEnriched
WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00040285:H2S_24hr_downregulated
WBPaper00040560:hpl-2_L3_downregulated
WBPaper00040990:PA14_upregulated
WBPaper00041954:ethanol_upregulated
WBPaper00043945:MeHg_downregulated
WBPaper00044316:CH3HgCl_0.75uM_upregulated
WBPaper00044316:HgCl2_20uM_upregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00045521:Gender_Neutral
WBPaper00045774:clk-1_downregulated
WBPaper00046415:lithium_downregulated
WBPaper00048923:Aging_regulated
WBPaper00048971:daf-16(mgDf50)_downregulated_L1
WBPaper00049018:swsn-2.2(RNAi)_downregulated
WBPaper00049134:hpk-1(pk1393)_upregulated
WBPaper00049498:npr-1(ur89)_regulated_7
WBPaper00049905:Age_variant_expression
WBPaper00050193:cec-4(ok3124)_upregulated_L1
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
WBPaper00050712:RC301_vs_DA650_4h-PA_upregulated
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050726:starvation_regulated_LowSalt
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00051069:isp-1(qm150)_downregulated
WBPaper00051558:aging_regulated
WBPaper00053295:lin-22(ot269)_downregulated
WBPaper00053318:Aging_upregulated_mRNA_N2
WBPaper00053318:mir-71(n4115)_upregulated_mRNA
WBPaper00053402:cco-1(RNAi)_upregulated
WBPaper00053402:his-3(RNAi)_upregulated
WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
WBPaper00053771:up_at_24h-NaCl
WBPaper00055013:hmg-3(bar24)_upregulated
WBPaper00055013:spt-16(RNAi)_upregulated
WBPaper00055103:thoc-5(wy822)_upregulated
WBPaper00055354:eat-2(ad1116)_downregulated
WBPaper00055354:Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055354:Rapamycin_downregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00055386:daf-2(e1370)_downregulated
WBPaper00055626:pry-1(mu38)_downregulated
WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00056275:P.aeruginosa_upregulated
WBPaper00056330:glycine_downregulated
WBPaper00056443:DietaryRestriction_upregulated
WBPaper00056809:smn-1(ok355)_upregulated
WBPaper00057041:unc-70(cas983)_downregulated
WBPaper00057068:ints-4(RNAi)_upregulated
WBPaper00057154:HeatShock_downregulated_mRNA
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058948:npr-8(ok1439)_upregulated_PA14
WBPaper00058948:PA14_downregulated
WBPaper00058955:heatshock_upregulated_CE
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00060399:CoCl2_6hr_upregulated_N2
WBPaper00060434:pH4.33_vs_pH6.33_uprgulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060909:atfs-1(cmh15)_upregulated
WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640)
WBPaper00061341:28C_48h_upregulated
WBPaper00061390:daf-22(ok693)_ascarosides_upregulated
WBPaper00061530:nhr-49(e2144)_downregulated
WBPaper00061590:CGP37157_upregulated
WBPaper00061613:human-alpha-Synuclein(A53T)_downregulated
WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_downregulated
WBPaper00061753:csr-1(tor159)_upregulated_25C
WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
WBPaper00062056:lin-35(n745)_upregulated
WBPaper00062184:PA14_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062345:bortezomib_4h_downregulated_N2
WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13)
WBPaper00062354:H.zoospora_6h_regulated
WBPaper00062456:doxycycline_upregulated_CB4856_protein
WBPaper00062456:doxycycline_upregulated_CB4856_transcript
WBPaper00062456:doxycycline_upregulated_N2_protein
WBPaper00062497:xpf-1(tm2842)_upregulated
WBPaper00062590:Aging_upregulated_intestine
WBPaper00062590:Aging_upregulated_neuron
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064375:sid-1(pk3321)_regulated
WBPaper00064509:static-magnetic-field_upregulated
WBPaper00064532:pals-22(jy3)_downregulated
WBPaper00064637:cox-5B(RNAi)_upregulated
WBPaper00064871:PA14_upregulated_AWA
WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
WBPaper00064939:vit-5(RNAi)_upregulated
WBPaper00064999:miR-229-64-65-66_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065746:tmc-1(rg1003)_upregulated
WBPaper00066005:RAGA-1_degradation_somatic_downregulated
WBPaper00066204:CdCl2_upregulated_mRNA
WBPaper00066232:ash-2(RNAi)_downregulated_WT
WBPaper00024393:strongly_regulated_dauer_genes
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00026952:class_E
WBPaper00028789:PA14_vs_gacA_upregulated_4hr
WBPaper00028789:PA14_vs_gacA_upregulated_8hr
WBPaper00028789:PA14_vs_OP50_upregulated_4hr
WBPaper00028789:PA14_vs_OP50_upregulated_8hr
WBPaper00031252:AIN-1_IP_enriched
WBPaper00031832:slr-2_regulated
WBPaper00031850:mdt-15(RNAi)_downregulated
WBPaper00032948:FedUp
WBPaper00034757:up_by_oxidative_stress
WBPaper00035873:dpy-9_regulated
WBPaper00035891:PA_induced_zip-2_dependent
WBPaper00035891:zip-2(RNAi)_downregulated
WBPaper00036130:mir-243_up_regulated
WBPaper00036286:Pattern_D
WBPaper00036383:ash-2_L3_regulated
WBPaper00037695:LD_3-day
WBPaper00038172:crh-1null_up_regulated
WBPaper00038427:lin-54_embryo_changed
WBPaper00040184:hcf-1down_sir-2.1down_daf-2down
WBPaper00040210:Chlorpyrifos_16C_regulated
WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
WBPaper00040210:Diazinon_24C_regulated
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_developing
WBPaper00040858:eQTL_regulated_juvenile
WBPaper00040858:eQTL_regulated_old
WBPaper00040963:TA300_up
WBPaper00041211:RPW-24_Up
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041876:daf-10(m79)_downreglated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:control_vs_UVC-exposed_51h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041960:N2_fasting_upregulated_anytime
WBPaper00044013:nasp-1_downregulated
WBPaper00044091:Bpseudomallei_induced_2h
WBPaper00044091:Bpseudomallei_induced_4h
WBPaper00044091:Bpseudomallei_induced_8h
WBPaper00044091:Bpseudomallei_induced_12h
WBPaper00044535:male_upregulated
WBPaper00045263:0.1mM-paraquat_downregulated
WBPaper00045263:isp-1(qm150)_downregulated
WBPaper00045263:nuo-6(qm200)_downregulated
WBPaper00045263:ProLongevity-mtROS_downregulated
WBPaper00045960:L4-lethargus_upregulated
WBPaper00046083:pmk-1(km25)_OP50_downregulated
WBPaper00046548:dafachronic-acid_downregulated
WBPaper00047070:xpa-1_UV_upregulated
WBPaper00048637:lin-35(n745)_starvation_upregulated
WBPaper00050515:nipi-3(fr4)_upregulated
WBPaper00050520:lagr-1(gk327);hyl-1(ok976)_upregulated
WBPaper00051448:P.aeruginosa_Liquid-Killing_upregulated
WBPaper00055899:nitroguanidine_regulated
[cgc5376]:let-60(G12V)-regulated_genes
[cgc6390]:Cluster_B
Interaction (45)
Map_infoMapXPosition2.62311Error0.016448
PositivePositive_cloneT21E8Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4578
4579
Pseudo_map_position
Reference (15)
RemarkSequence connection from [Sheps JA, Baillie DL] [040902 ck1]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene