WormBase Tree Display for Gene: WBGene00003918
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| WBGene00003918 | SMap | S_parent | Sequence | F54E7 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | par-3 | Person_evidence | WBPerson314 | |||||
| Sequence_name | F54E7.3 | ||||||||
| Molecular_name (42) | |||||||||
| Other_name | CELE_F54E7.3 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | par-3 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | par | ||||||||
| Reference_allele | WBVar00144542 | ||||||||
| Allele (192) | |||||||||
| Legacy_information | [Etemad-Moghadam B] par for partitioning defective. Maternal effect lethal mutation that affects first two embryonic cell cycles. | ||||||||
| [C.elegansII] e2074amb : maternal effect lethal mutation, affects first two embryonic cell cycles; abnormal pseudocleavage, streaming, P granule localization; 2nd cleavage spindle orientation variable, often both longitudinal (ectopic rotation in AB).OA5: it54 (leaky, Mes), it71amb (null), it62, it91. Cloned: encodes predicted 138 kD novel protein. Antibody staining indicates specific asymmetric peripheral localizations in early blastomeres. [Cheng et al. 1995; KK] | |||||||||
| [Schnabel H] maternal-effect embryonic lethal | |||||||||
| Strain (12) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (51) | |||||||||
| Ortholog (41) | |||||||||
| Structured_description | Concise_description | par-3 encodes a PDZ domain-containing protein orthologous to mammalian atypical PKC isotype-specific interacting protein (ASIP) and Drosophila Bazooka; PAR-3 is required maternally for polarization of the zygote along the anterior-posterior (A-P) axis; PAR-3, PAR-6, and PKC-3 form a complex that localizes to the anterior cytoplasmic cortex of the one- and two-cell embryo; this localization is regulated spatially by PAR-2, which segregates to the posterior cortex. | Paper_evidence | WBPaper00004672 | |||||
| WBPaper00005115 | |||||||||
| WBPaper00005347 | |||||||||
| WBPaper00005653 | |||||||||
| WBPaper00005735 | |||||||||
| WBPaper00005778 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable phosphatidylinositol binding activity. Involved in several processes, including establishment of mitotic spindle orientation; gonad development; and polarity specification of anterior/posterior axis. Located in several cellular components, including P granule; basal part of cell; and cell cortex. Is extrinsic component of cytoplasmic side of plasma membrane. Expressed in several structures, including AB; Psub1; excretory cell; hermaphrodite gonad; and vulval cell. Is an ortholog of human PARD3B (par-3 family cell polarity regulator beta). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS (13) | ||||||||
| Corresponding_transcript (16) | |||||||||
| Other_sequence (19) | |||||||||
| Associated_feature (21) | |||||||||
| Experimental_info | RNAi_result (65) | ||||||||
| Expr_pattern | Expr1558 | ||||||||
| Expr1821 | |||||||||
| Expr2934 | |||||||||
| Expr3436 | |||||||||
| Expr11916 | |||||||||
| Expr1019819 | |||||||||
| Expr1031851 | |||||||||
| Expr1152146 | |||||||||
| Expr2014728 | |||||||||
| Expr2032962 | |||||||||
| Drives_construct (19) | |||||||||
| Construct_product | WBCnstr00000666 | ||||||||
| WBCnstr00005202 | |||||||||
| WBCnstr00006081 | |||||||||
| WBCnstr00007516 | |||||||||
| WBCnstr00007517 | |||||||||
| WBCnstr00009173 | |||||||||
| WBCnstr00009174 | |||||||||
| WBCnstr00019545 | |||||||||
| WBCnstr00020202 | |||||||||
| WBCnstr00035797 | |||||||||
| Antibody (12) | |||||||||
| Microarray_results (49) | |||||||||
| Expression_cluster (166) | |||||||||
| Interaction (486) | |||||||||
| WBProcess | WBbiopr:00000017 | ||||||||
| Map_info | Map | III | Position | -1.46058 | Error | 0.000572 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F54E7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Negative | Outside_rearr | sDf121 | |||||||
| sDf127 | |||||||||
| sDf125 | |||||||||
| Negative_clone | F46E7 | ||||||||
| R06G9 | |||||||||
| Mapping_data | 2_point | 2725 | |||||||
| 6133 | |||||||||
| Multi_point | 1096 | ||||||||
| 1444 | |||||||||
| 1723 | |||||||||
| 2327 | |||||||||
| 5250 | |||||||||
| Pos_neg_data | 8417 | ||||||||
| 10181 | |||||||||
| 10182 | |||||||||
| 10183 | |||||||||
| Reference (340) | |||||||||
| Method | Gene |
