WormBase Tree Display for Gene: WBGene00003918

WBGene00003918 SMap: S_parent: Sequence: F54E7
  Identity: Version: 1
    Name: CGC_name: par-3 Person_evidence: WBPerson314
      Sequence_name: F54E7.3
      Molecular_name (42)
      Other_name: CELE_F54E7.3 Accession_evidence: NDB BX284603
      Public_name: par-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: par
    Reference_allele: WBVar00144542
    Allele (192)
    Legacy_information: [Etemad-Moghadam B] par for partitioning defective. Maternal effect lethal mutation that affects first two embryonic cell cycles.
      [C.elegansII] e2074amb : maternal effect lethal mutation, affects first two embryonic cell cycles; abnormal pseudocleavage, streaming, P granule localization; 2nd cleavage spindle orientation variable, often both longitudinal (ectopic rotation in AB).OA5: it54 (leaky, Mes), it71amb (null), it62, it91. Cloned: encodes predicted 138 kD novel protein. Antibody staining indicates specific asymmetric peripheral localizations in early blastomeres. [Cheng et al. 1995; KK]
      [Schnabel H] maternal-effect embryonic lethal
    Strain (12)
    RNASeq_FPKM (74)
    GO_annotation (51)
    Ortholog (41)
    Structured_description: Concise_description: par-3 encodes a PDZ domain-containing protein orthologous to mammalian atypical PKC isotype-specific interacting protein (ASIP) and Drosophila Bazooka; PAR-3 is required maternally for polarization of the zygote along the anterior-posterior (A-P) axis; PAR-3, PAR-6, and PKC-3 form a complex that localizes to the anterior cytoplasmic cortex of the one- and two-cell embryo; this localization is regulated spatially by PAR-2, which segregates to the posterior cortex. Paper_evidence: WBPaper00004672
            WBPaper00005115
            WBPaper00005347
            WBPaper00005653
            WBPaper00005735
            WBPaper00005778
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable phosphatidylinositol binding activity. Involved in several processes, including establishment of mitotic spindle orientation; gonad development; and polarity specification of anterior/posterior axis. Located in several cellular components, including P granule; basal part of cell; and cell cortex. Is extrinsic component of cytoplasmic side of plasma membrane. Expressed in several structures, including AB; Psub1; excretory cell; hermaphrodite gonad; and vulval cell. Is an ortholog of human PARD3B (par-3 family cell polarity regulator beta). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS (13)
    Corresponding_transcript (16)
    Other_sequence (19)
    Associated_feature (21)
  Experimental_info: RNAi_result (65)
    Expr_pattern: Expr1558
      Expr1821
      Expr2934
      Expr3436
      Expr11916
      Expr1019819
      Expr1031851
      Expr1152146
      Expr2014728
      Expr2032962
    Drives_construct (19)
    Construct_product: WBCnstr00000666
      WBCnstr00005202
      WBCnstr00006081
      WBCnstr00007516
      WBCnstr00007517
      WBCnstr00009173
      WBCnstr00009174
      WBCnstr00019545
      WBCnstr00020202
      WBCnstr00035797
    Antibody (12)
    Microarray_results (49)
    Expression_cluster (166)
    Interaction: WBInteraction000000267
      WBInteraction000000268
      WBInteraction000000427
      WBInteraction000000435
      WBInteraction000000437
      WBInteraction000000627
      WBInteraction000001615
      WBInteraction000001617
      WBInteraction000002235
      WBInteraction000002648
      WBInteraction000003020
      WBInteraction000003101
      WBInteraction000003107
      WBInteraction000003151
      WBInteraction000003152
      WBInteraction000003208
      WBInteraction000003277
      WBInteraction000003278
      WBInteraction000003324
      WBInteraction000003325
      WBInteraction000003356
      WBInteraction000003539
      WBInteraction000003575
      WBInteraction000003578
      WBInteraction000003668
      WBInteraction000003671
      WBInteraction000003968
      WBInteraction000003969
      WBInteraction000005199
      WBInteraction000005209
      WBInteraction000005210
      WBInteraction000006974
      WBInteraction000007008
      WBInteraction000009119
      WBInteraction000009271
      WBInteraction000009298
      WBInteraction000009349
      WBInteraction000009438
      WBInteraction000009445
      WBInteraction000009455
      WBInteraction000009468
      WBInteraction000009534
      WBInteraction000009562
      WBInteraction000009595
      WBInteraction000009729
      WBInteraction000028279
      WBInteraction000028406
      WBInteraction000028669
      WBInteraction000028675
      WBInteraction000029076
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      WBInteraction000032560
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      WBInteraction000033047
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      WBInteraction000033146
      WBInteraction000033467
      WBInteraction000034266
      WBInteraction000034325
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      WBInteraction000544689
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      WBInteraction000544743
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      WBInteraction000546243
      WBInteraction000553676
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      WBInteraction000553678
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      WBInteraction000553680
      WBInteraction000553681
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      WBInteraction000553684
      WBInteraction000553685
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      WBInteraction000553688
      WBInteraction000553689
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      WBInteraction000553700
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      WBInteraction000553795
      WBInteraction000553796
      WBInteraction000553797
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      WBInteraction000553799
      WBInteraction000553800
      WBInteraction000553801
      WBInteraction000553802
      WBInteraction000553803
      WBInteraction000553804
      WBInteraction000553805
      WBInteraction000553806
      WBInteraction000553807
      WBInteraction000553808
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      WBInteraction000553810
      WBInteraction000553811
      WBInteraction000553812
      WBInteraction000553813
      WBInteraction000553814
      WBInteraction000553815
      WBInteraction000553816
      WBInteraction000553817
      WBInteraction000553818
      WBInteraction000553819
      WBInteraction000553820
      WBInteraction000553821
      WBInteraction000553822
      WBInteraction000553823
      WBInteraction000555749
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      WBInteraction000556163
      WBInteraction000556169
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      WBInteraction000557480
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    WBProcess: WBbiopr:00000017
  Map_info: Map: III Position: -1.46058 Error: 0.000572
    Well_ordered
    Positive: Positive_clone: F54E7 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Outside_rearr: sDf121
        sDf127
        sDf125
      Negative_clone: F46E7
        R06G9
    Mapping_data: 2_point: 2725
        6133
      Multi_point: 1096
        1444
        1723
        2327
        5250
      Pos_neg_data: 8417
        10181
        10182
        10183
  Reference (340)
  Method: Gene