WormBase Tree Display for Gene: WBGene00003914
expand all nodes | collapse all nodes | view schema
| WBGene00003914 | Evidence | Person_evidence | WBPerson2626 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| WBPerson1106 | |||||||||
| SMap | S_parent | Sequence | F49E8 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | pam-1 | |||||||
| Sequence_name | F49E8.3 | ||||||||
| Molecular_name | F49E8.3a | ||||||||
| F49E8.3a.1 | |||||||||
| CE10790 | |||||||||
| F49E8.3b | |||||||||
| CE37649 | |||||||||
| F49E8.3a.2 | |||||||||
| F49E8.3a.3 | |||||||||
| F49E8.3b.1 | |||||||||
| Other_name | scu-1 | Paper_evidence | WBPaper00028560 | ||||||
| CELE_F49E8.3 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | pam-1 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00003914 | |||||
| WormFlux | gene | WBGene00003914 | |||||||
| NDB | locus_tag | CELE_F49E8.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003914|UniProtKB=Q4TT88 | |||||||
| family | PTHR11533 | ||||||||
| NCBI | gene | 177528 | |||||||
| RefSeq | protein | NM_001028039.3 | |||||||
| NM_001392330.1 | |||||||||
| KEGG | KEGG_id | 3.4.11.14 | |||||||
| NemaPath | KEGG_id | 3.4.11.14 | |||||||
| SwissProt | UniProtAcc | Q4TT88 | |||||||
| UniProt_GCRP | UniProtAcc | Q4TT88 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 19 Oct 2006 10:23:17 | WBPerson2970 | Name_change | Other_name | scu-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pam | ||||||||
| Allele (89) | |||||||||
| Strain | WBStrain00031440 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (52) | |||||||||
| Contained_in_operon | CEOP4228 | ||||||||
| CEOP4618 | |||||||||
| Ortholog (68) | |||||||||
| Paralog (13) | |||||||||
| Structured_description | Concise_description | pam-1 encodes a metalloprotease that is the C. elegans puromycin-sensitive aminopeptidase (PSA) ortholog; in the one-cell embryo, PAM-1 is required for timely exit from meiosis II proper centrosome positioning, proper localization of polarity and cell fate determinants, and formation of the anteroposterior axis; genetic studies indicate that cyb-3, which encodes a B-type cyclin, is required for pam-1(lf) meiotic exit defects, suggesting that CYB-3 activity is regulated by PAM-1, directly or indirectly, in the early embryo; a pam-1::gfp reporter fusion is expressed in embryos, larvae, and adults; in larvae and adults, expression is particularly notable in the posterior intestine and amphid sensory neurons; in males, expression is also seen in neurons in the developing and mature male tail; in vitro, PAM-1 exhibits metal-dependent aminopeptidase activity, hydrolyzing the N-terminal amino acid from various peptide substrates. | Paper_evidence | WBPaper00006165 | |||||
| WBPaper00028560 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 28 Nov 2007 00:00:00 | ||||||||
| Automated_description | Enables metalloaminopeptidase activity. Involved in several processes, including exit from meiosis; first cell cycle pseudocleavage; and regulation of reproductive process. Located in condensed chromosome; cytoplasm; and mitotic spindle pole. Expressed in amphid process; intestine; male-specific anatomical entity; nerve ring; and tail neurons. Is an ortholog of human NPEPPS (aminopeptidase puromycin sensitive). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F49E8.3a | |||||||
| F49E8.3b | |||||||||
| Corresponding_CDS_history | F49E8.3:wp143 | ||||||||
| Corresponding_transcript | F49E8.3a.1 | ||||||||
| F49E8.3a.2 | |||||||||
| F49E8.3a.3 | |||||||||
| F49E8.3b.1 | |||||||||
| Other_sequence (59) | |||||||||
| Associated_feature | WBsf997007 | ||||||||
| WBsf230289 | |||||||||
| WBsf230290 | |||||||||
| WBsf230291 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00047870 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00047869 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076453 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089085 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062566 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00008824 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00032551 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram871 | ||||||||
| Chronogram872 | |||||||||
| Chronogram1758 | |||||||||
| Expr2635 | |||||||||
| Expr9077 | |||||||||
| Expr1016847 | |||||||||
| Expr1031847 | |||||||||
| Expr1151700 | |||||||||
| Expr2014716 | |||||||||
| Expr2032950 | |||||||||
| Drives_construct | WBCnstr00010880 | ||||||||
| WBCnstr00035799 | |||||||||
| Construct_product | WBCnstr00010880 | ||||||||
| WBCnstr00035799 | |||||||||
| Antibody | WBAntibody00002146 | ||||||||
| Microarray_results (27) | |||||||||
| Expression_cluster (131) | |||||||||
| Interaction (92) | |||||||||
| Map_info | Map | IV | Position | 3.34579 | Error | 0.001269 | |||
| Positive | Positive_clone | F49E8 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4190 | |||||||
| 4563 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (26) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
