WormBase Tree Display for Gene: WBGene00003914
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WBGene00003914 | Evidence | Person_evidence | WBPerson2626 | ||||
---|---|---|---|---|---|---|---|
WBPerson1106 | |||||||
SMap | S_parent | Sequence | F49E8 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | pam | ||||||
Allele (89) | |||||||
Strain | WBStrain00031440 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (52) | |||||||
Contained_in_operon | CEOP4228 | ||||||
CEOP4618 | |||||||
Ortholog (68) | |||||||
Paralog (13) | |||||||
Structured_description | Concise_description | pam-1 encodes a metalloprotease that is the C. elegans puromycin-sensitive aminopeptidase (PSA) ortholog; in the one-cell embryo, PAM-1 is required for timely exit from meiosis II proper centrosome positioning, proper localization of polarity and cell fate determinants, and formation of the anteroposterior axis; genetic studies indicate that cyb-3, which encodes a B-type cyclin, is required for pam-1(lf) meiotic exit defects, suggesting that CYB-3 activity is regulated by PAM-1, directly or indirectly, in the early embryo; a pam-1::gfp reporter fusion is expressed in embryos, larvae, and adults; in larvae and adults, expression is particularly notable in the posterior intestine and amphid sensory neurons; in males, expression is also seen in neurons in the developing and mature male tail; in vitro, PAM-1 exhibits metal-dependent aminopeptidase activity, hydrolyzing the N-terminal amino acid from various peptide substrates. | Paper_evidence | WBPaper00006165 | |||
WBPaper00028560 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 28 Nov 2007 00:00:00 | ||||||
Automated_description | Enables metalloaminopeptidase activity. Involved in several processes, including exit from meiosis; first cell cycle pseudocleavage; and regulation of reproductive process. Located in condensed chromosome; cytoplasm; and mitotic spindle pole. Expressed in amphid process; intestine; male-specific anatomical entity; nerve ring; and tail neurons. Is an ortholog of human NPEPPS (aminopeptidase puromycin sensitive). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | F49E8.3a | |||||
F49E8.3b | |||||||
Corresponding_CDS_history | F49E8.3:wp143 | ||||||
Corresponding_transcript | F49E8.3a.1 | ||||||
F49E8.3a.2 | |||||||
F49E8.3a.3 | |||||||
F49E8.3b.1 | |||||||
Other_sequence (59) | |||||||
Associated_feature | WBsf997007 | ||||||
WBsf230289 | |||||||
WBsf230290 | |||||||
WBsf230291 | |||||||
Experimental_info | RNAi_result | WBRNAi00047870 | Inferred_automatically | RNAi_primary | |||
WBRNAi00047869 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00076453 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00089085 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00062566 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00008824 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00032551 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Chronogram871 | ||||||
Chronogram872 | |||||||
Chronogram1758 | |||||||
Expr2635 | |||||||
Expr9077 | |||||||
Expr1016847 | |||||||
Expr1031847 | |||||||
Expr1151700 | |||||||
Expr2014716 | |||||||
Expr2032950 | |||||||
Drives_construct | WBCnstr00010880 | ||||||
WBCnstr00035799 | |||||||
Construct_product | WBCnstr00010880 | ||||||
WBCnstr00035799 | |||||||
Antibody | WBAntibody00002146 | ||||||
Microarray_results (27) | |||||||
Expression_cluster (131) | |||||||
Interaction (92) | |||||||
Map_info | Map | IV | Position | 3.34579 | Error | 0.001269 | |
Positive | Positive_clone | F49E8 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 4190 | |||||
4563 | |||||||
Pseudo_map_position | |||||||
Reference (26) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |