WormBase Tree Display for Gene: WBGene00003909

WBGene00003909 SMap: S_parent: Sequence: F45B8
  Identity: Version: 1
    Name: CGC_name: pag-3
      Sequence_name: F45B8.4
      Molecular_name: F45B8.4
        F45B8.4.1
        CE24977
      Other_name: CELE_F45B8.4 Accession_evidence: NDB BX284606
      Public_name: pag-3
    DB_info: Database: AceView gene XP570
        WormQTL gene WBGene00003909
        WormFlux gene WBGene00003909
        NDB locus_tag CELE_F45B8.4
        Panther gene CAEEL|WormBase=WBGene00003909|UniProtKB=G5EDE1
          family PTHR24390
        NCBI gene 181588
        RefSeq protein NM_078079.6
        SwissProt UniProtAcc G5EDE1
        TREEFAM TREEFAM_ID TF317208
        UniProt_GCRP UniProtAcc G5EDE1
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pag
    Allele (82)
    Legacy_information: [Aamodt EJ, Jia Y] ls20 causes misexpression of the mec-7 gene, mec-7lacZ and mec-4lacZ fusion genes in the BDU neurons. Also causes a reverse kinker uncoordinated phenotype, and occasional axonal guidance errors in the PLM and BDU neurons. NA1.
      [C.elegansII] ls20 : homozygotes exhibit misexpression of the mec-7 gene, mec-7lacZ and mec-4lacZ fusion genes in the BDU neurons. Also causes a reverse kinker uncoordinated phenotype, and occasional axonal guidance errors in the PLM and BDU neurons. NA1. [EA]
      [Aamodt EJ] predicted gene F45B8.4
    Strain: WBStrain00027353
      WBStrain00035715
      WBStrain00006454
    RNASeq_FPKM (74)
    GO_annotation (23)
    Ortholog (38)
    Paralog: WBGene00012639 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017430 Caenorhabditis elegans From_analysis: Panther
      WBGene00009937 Caenorhabditis elegans From_analysis: Panther
      WBGene00022762 Caenorhabditis elegans From_analysis: Panther
      WBGene00015138 Caenorhabditis elegans From_analysis: Panther
      WBGene00009508 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: pag-3 encodes a C2H2 zinc-finger protein orthologous to DrosophilaSENSELESS, and to human GFI1 (OMIM:600871, mutated in neutropenia) andGFI1B (OMIM:604383); pag-3 is expressed in neurons (touch receptors, BDUinterneurons, ventral cord motor neurons, and others); PAG-3 is requiredto repress the touch neuron-specific genes mec-4 and mec-7 in BDUneurons, but since this repression does not occur in touch neurons(which also have PAG-3), PAG-3 may require another protein or proteinsfor repression (such as PRK-1 or PRK-2, the C. elegans orthologs ofhuman PIM-1); PAG-3 is also needed for normal neuroblast lineages in theventral nerve cord, and for normal locomotion; pag-3 mutants have areverse kinker uncoordinated phenotype, and occasional axonal guidanceerrors in the PLM and BDU neurons; PAG-3's similarity to GFI1 and GFIBfalls mainly within residues 159-261, but within these residues (whichoverlap PAG-3's five zinc-finger domains in residues 126-265) the aminoacid identity is 87%; pag-3 transcript quantities are doubled in pag-3mutants, suggesting that PAG-3 inhibits its own gene. Paper_evidence: WBPaper00002355
            WBPaper00002800
            WBPaper00003922
            WBPaper00005229
            WBPaper00005359
            WBPaper00028605
          Person_evidence: WBPerson2238
          Curator_confirmed: WBPerson567
          Date_last_updated: 26 Oct 2006 00:00:00
      Automated_description: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; transcription corepressor activity; and transcription corepressor binding activity. Involved in several processes, including negative regulation of secretion by cell; neuroblast fate specification; and regulation of locomotion. Located in nucleus. Expressed in several structures, including P1.aap; P11.aaap; P12.aaap; neurons; and retrovesicular ganglion. Used to study alcohol use disorder. Is an ortholog of human ZNF683 (zinc finger protein 683). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:1574 Homo sapiens Paper_evidence: WBPaper00041098
          Curator_confirmed: WBPerson324
          Date_last_updated: 05 Jun 2019 00:00:00
  Models_disease_asserted: WBDOannot00000696
  Molecular_info: Corresponding_CDS: F45B8.4
    Corresponding_transcript: F45B8.4.1
    Other_sequence (19)
    Associated_feature (12)
    Transcription_factor: WBTranscriptionFactor000513
  Experimental_info: RNAi_result: WBRNAi00027820 Inferred_automatically: RNAi_primary
      WBRNAi00047348 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr521
      Expr1872
      Expr1018152
      Expr1031844
      Expr1151201
      Expr1200026
      Expr2014684
      Expr2032917
    Drives_construct: WBCnstr00012418
      WBCnstr00035802
    Construct_product: WBCnstr00012418
      WBCnstr00020653
      WBCnstr00021744
      WBCnstr00035802
    Antibody: WBAntibody00000504
    Microarray_results (20)
    Expression_cluster (113)
    Interaction (51)
    WBProcess: WBbiopr:00000024
  Map_info: Map: X Position: 21.592 Error: 0.004611
    Well_ordered
    Positive: Positive_clone: F45B8 Inferred_automatically: From sequence, transcript, pseudogene data
        Y37H4
    Mapping_data: 2_point: 7015
      Multi_point: 4508
        5033
      Pos_neg_data (11)
  Reference (51)
  Method: Gene