WormBase Tree Display for Gene: WBGene00003909
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WBGene00003909 | SMap | S_parent | Sequence | F45B8 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | pag | ||||||
Allele (82) | |||||||
Legacy_information | [Aamodt EJ, Jia Y] ls20 causes misexpression of the mec-7 gene, mec-7lacZ and mec-4lacZ fusion genes in the BDU neurons. Also causes a reverse kinker uncoordinated phenotype, and occasional axonal guidance errors in the PLM and BDU neurons. NA1. | ||||||
[C.elegansII] ls20 : homozygotes exhibit misexpression of the mec-7 gene, mec-7lacZ and mec-4lacZ fusion genes in the BDU neurons. Also causes a reverse kinker uncoordinated phenotype, and occasional axonal guidance errors in the PLM and BDU neurons. NA1. [EA] | |||||||
[Aamodt EJ] predicted gene F45B8.4 | |||||||
Strain | WBStrain00027353 | ||||||
WBStrain00035715 | |||||||
WBStrain00006454 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (23) | |||||||
Ortholog (38) | |||||||
Paralog | WBGene00012639 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00017430 | Caenorhabditis elegans | From_analysis | Panther | ||||
WBGene00009937 | Caenorhabditis elegans | From_analysis | Panther | ||||
WBGene00022762 | Caenorhabditis elegans | From_analysis | Panther | ||||
WBGene00015138 | Caenorhabditis elegans | From_analysis | Panther | ||||
WBGene00009508 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | pag-3 encodes a C2H2 zinc-finger protein orthologous to DrosophilaSENSELESS, and to human GFI1 (OMIM:600871, mutated in neutropenia) andGFI1B (OMIM:604383); pag-3 is expressed in neurons (touch receptors, BDUinterneurons, ventral cord motor neurons, and others); PAG-3 is requiredto repress the touch neuron-specific genes mec-4 and mec-7 in BDUneurons, but since this repression does not occur in touch neurons(which also have PAG-3), PAG-3 may require another protein or proteinsfor repression (such as PRK-1 or PRK-2, the C. elegans orthologs ofhuman PIM-1); PAG-3 is also needed for normal neuroblast lineages in theventral nerve cord, and for normal locomotion; pag-3 mutants have areverse kinker uncoordinated phenotype, and occasional axonal guidanceerrors in the PLM and BDU neurons; PAG-3's similarity to GFI1 and GFIBfalls mainly within residues 159-261, but within these residues (whichoverlap PAG-3's five zinc-finger domains in residues 126-265) the aminoacid identity is 87%; pag-3 transcript quantities are doubled in pag-3mutants, suggesting that PAG-3 inhibits its own gene. | Paper_evidence | WBPaper00002355 | |||
WBPaper00002800 | |||||||
WBPaper00003922 | |||||||
WBPaper00005229 | |||||||
WBPaper00005359 | |||||||
WBPaper00028605 | |||||||
Person_evidence | WBPerson2238 | ||||||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 26 Oct 2006 00:00:00 | ||||||
Automated_description | Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; transcription corepressor activity; and transcription corepressor binding activity. Involved in several processes, including negative regulation of secretion by cell; neuroblast fate specification; and regulation of locomotion. Located in nucleus. Expressed in several structures, including P1.aap; P11.aaap; P12.aaap; neurons; and retrovesicular ganglion. Used to study alcohol use disorder. Is an ortholog of human ZNF683 (zinc finger protein 683). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00041098 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 05 Jun 2019 00:00:00 | ||||||
Models_disease_asserted | WBDOannot00000696 | ||||||
Molecular_info | Corresponding_CDS | F45B8.4 | |||||
Corresponding_transcript | F45B8.4.1 | ||||||
Other_sequence (19) | |||||||
Associated_feature (12) | |||||||
Transcription_factor | WBTranscriptionFactor000513 | ||||||
Experimental_info | RNAi_result | WBRNAi00027820 | Inferred_automatically | RNAi_primary | |||
WBRNAi00047348 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr521 | ||||||
Expr1872 | |||||||
Expr1018152 | |||||||
Expr1031844 | |||||||
Expr1151201 | |||||||
Expr1200026 | |||||||
Expr2014684 | |||||||
Expr2032917 | |||||||
Drives_construct | WBCnstr00012418 | ||||||
WBCnstr00035802 | |||||||
Construct_product | WBCnstr00012418 | ||||||
WBCnstr00020653 | |||||||
WBCnstr00021744 | |||||||
WBCnstr00035802 | |||||||
Antibody | WBAntibody00000504 | ||||||
Microarray_results (20) | |||||||
Expression_cluster (113) | |||||||
Interaction (51) | |||||||
WBProcess | WBbiopr:00000024 | ||||||
Map_info | Map | X | Position | 21.592 | Error | 0.004611 | |
Well_ordered | |||||||
Positive | Positive_clone | F45B8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Y37H4 | |||||||
Mapping_data | 2_point | 7015 | |||||
Multi_point | 4508 | ||||||
5033 | |||||||
Pos_neg_data (11) | |||||||
Reference (51) | |||||||
Method | Gene |