WormBase Tree Display for Gene: WBGene00003889

WBGene00003889 SMap: S_parent: Sequence: B0212
  Identity: Version: 1
    Name: CGC_name: osm-9 Person_evidence: WBPerson242
      Sequence_name: B0212.5
      Molecular_name: B0212.5
        B0212.5.1
        CE20445
      Other_name: nss-2
        CELE_B0212.5 Accession_evidence: NDB BX284604
      Public_name: osm-9
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: osm
    Allele: WBVar00090217
      WBVar00090494
      WBVar00274907
      WBVar00274909
      WBVar00090568
      WBVar02141212
      WBVar00090921
      WBVar00090215
      WBVar00088410
      WBVar00088387
      WBVar00421497
      WBVar00421498
      WBVar00421499
      WBVar00421500
      WBVar00421501
      WBVar00421502
      WBVar00421503
      WBVar00421504
      WBVar00421505
      WBVar00421506
      WBVar00421507
      WBVar00258568
      WBVar01668486
      WBVar00421508
      WBVar00421509
      WBVar01727051
      WBVar01727052
      WBVar00421510
      WBVar00421511
      WBVar02151637
      WBVar01451776
      WBVar01451778
      WBVar01451779
      WBVar00899316
      WBVar00899317
      WBVar01451780
      WBVar00899318
      WBVar01451781
      WBVar01451782
      WBVar00899319
      WBVar00899320
      WBVar00899321
      WBVar00899322
      WBVar00899323
      WBVar00899324
      WBVar00899325
      WBVar00899326
      WBVar00899327
      WBVar00899328
      WBVar00899329
      WBVar00092885
      WBVar00899330
      WBVar01630350
      WBVar00275616
      WBVar00899331
      WBVar00899332
      WBVar00899333
      WBVar00899334
      WBVar00899335
      WBVar00899336
      WBVar00899337
      WBVar00899338
      WBVar00899339
      WBVar00899340
      WBVar00899341
      WBVar00899342
      WBVar00899343
      WBVar00899344
      WBVar00899345
      WBVar00899346
      WBVar01922883
      WBVar01922884
      WBVar00899347
      WBVar01922885
      WBVar00899348
      WBVar00899349
      WBVar00899350
      WBVar00899351
      WBVar00899352
      WBVar00899353
      WBVar00899354
      WBVar01514941
      WBVar01499240
      WBVar00090199
      WBVar01514942
      WBVar01499241
      WBVar01514943
      WBVar02133610
      WBVar01514944
      WBVar02133611
      WBVar01514945
      WBVar02133612
      WBVar01514946
      WBVar02133613
      WBVar01514947
      WBVar01514948
      WBVar01514949
      WBVar00600938
      WBVar00600939
      WBVar00600940
      WBVar01499633
      WBVar00275450
      WBVar01481633
      WBVar01481634
      WBVar01481635
      WBVar00187542
      WBVar00187543
      WBVar00187544
      WBVar00187545
      WBVar00187546
      WBVar02020406
      WBVar00187547
      WBVar00187548
      WBVar00187549
      WBVar00571409
      WBVar00571410
      WBVar02082314
      WBVar00571413
      WBVar00571414
      WBVar00571415
    Legacy_information: [C.elegansII] n1601 : defective in osmotic avoidance, also in nose touch avoidance (Not); Adp (partly defective adaptation to isoamyl alcohol and butanone); normal chemotaxis.OA5: n1516, n1603, n2473, ky10 (similar). [Colbert & Bargmann 1995; JT; KP; MT]
    Strain: WBStrain00023453
      WBStrain00036458
      WBStrain00005214
      WBStrain00007483
      WBStrain00052609
    RNASeq_FPKM (74)
    GO_annotation (33)
    Ortholog (45)
    Paralog: WBGene00003838 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00003839 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00003840 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00003841 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: osm-9 encodes a TRPV channel homologous to capsaicin receptors; osm-9 is involved in sensory responses to a subset of chemical stimuli and to ASH neuron-mediated osmotic and mechanical stimuli; OSM-9 is also involved in adaptation to volatile odorants and salts; OSM-9 is expressed in a variety of sensory neurons and shows neuron-specific localization to either the cell body or the cilium. Paper_evidence: WBPaper00002166
            WBPaper00002930
            WBPaper00005150
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 20 Apr 2011 00:00:00
      Automated_description: Enables calcium channel activity and temperature-gated cation channel activity. Involved in several processes, including heat acclimation; negative adaptation of signaling pathway; and nervous system process. Located in neuronal cell body; non-motile cilium; and perinuclear region of cytoplasm. Expressed in RIG; head mesodermal cell; rectal gland cell; sensory neurons; and uterine toroidal epithelial cell. Human ortholog(s) of this gene implicated in several diseases, including keratosis (multiple); motor neuron disease (multiple); and osteochondrodysplasia (multiple). Is an ortholog of human TRPV3 (transient receptor potential cation channel subfamily V member 3); TRPV4 (transient receptor potential cation channel subfamily V member 4); and TRPV5 (transient receptor potential cation channel subfamily V member 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (17)
  Molecular_info: Corresponding_CDS: B0212.5
    Corresponding_transcript: B0212.5.1
    Other_sequence (14)
    Associated_feature: WBsf667839
      WBsf995982
  Experimental_info: RNAi_result (14)
    Expr_pattern (12)
    Drives_construct: WBCnstr00000837
      WBCnstr00005979
      WBCnstr00008561
      WBCnstr00010985
      WBCnstr00010991
      WBCnstr00011000
      WBCnstr00011004
      WBCnstr00012945
      WBCnstr00023098
      WBCnstr00035811
    Construct_product: WBCnstr00000837
      WBCnstr00006801
      WBCnstr00010991
      WBCnstr00011000
      WBCnstr00011004
      WBCnstr00012945
      WBCnstr00020618
      WBCnstr00035811
    Regulate_expr_cluster: WBPaper00049594:osm-9(ok1677)_NaCl(200mM)_upregulate
      WBPaper00049594:osm-9(ok1677)_upregulated
    Microarray_results (18)
    Expression_cluster (103)
    Interaction (116)
    Anatomy_function: WBbtf0291
    WBProcess: WBbiopr:00000002
  Map_info: Map: IV Position: -3.15659 Error: 0.016734
    Well_ordered
    Positive: Positive_clone: B0212 Inferred_automatically: From sequence, transcript, pseudogene data
        CX#2-12
    Mapping_data: 2_point: 3729
        3730
      Multi_point: 1365
        1366
  Reference (225)
  Remark: Possibly homologous to mammalian capsaicin receptor VR1. Some osm-9 mutants are sensitive to capsaicin.[bionet.celegans from Olsen] Curator_confirmed: WBPerson1250
  Method: Gene