WormBase Tree Display for Gene: WBGene00003847
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WBGene00003847 | SMap | S_parent | Sequence | F25D7 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 3 | |||||
Name | CGC_name | blmp-1 | Paper_evidence | WBPaper00045431 | |||
Person_evidence | WBPerson3099 | ||||||
Sequence_name | F25D7.3 | ||||||
Molecular_name | F25D7.3a | ||||||
F25D7.3a.1 | |||||||
CE09631 | |||||||
F25D7.3b | |||||||
CE43409 | |||||||
F25D7.3b.1 | |||||||
Other_name | odd-3 | CGC_data_submission | |||||
dpy-24 | Person_evidence | WBPerson261 | |||||
CELE_F25D7.3 | Accession_evidence | NDB | BX284601 | ||||
Public_name | blmp-1 | ||||||
DB_info | Database | AceView | gene | 1K989 | |||
WormQTL | gene | WBGene00003847 | |||||
WormFlux | gene | WBGene00003847 | |||||
NDB | locus_tag | CELE_F25D7.3 | |||||
Panther | gene | CAEEL|WormBase=WBGene00003847|UniProtKB=Q93560 | |||||
family | PTHR16515 | ||||||
NCBI | gene | 172917 | |||||
RefSeq | protein | NM_001264442.2 | |||||
NM_001264441.2 | |||||||
SwissProt | UniProtAcc | Q93560 | |||||
TREEFAM | TREEFAM_ID | TF316545 | |||||
UniProt_GCRP | UniProtAcc | Q93560 | |||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (3) | ||||||
Acquires_merge | WBGene00001083 | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | blmp | ||||||
Allele (68) | |||||||
Legacy_information | s71 : weak dumpy. ES3 (adult) ES1 (larvae). NA1. | ||||||
[C.elegansII] s71 : weak dumpy; abnormal DTC migration. ES3 (adult) ES1 (larvae). NA1. [Hedgecock et al. 1987; BC; BS] | |||||||
Strain | WBStrain00022557 | ||||||
WBStrain00034109 | |||||||
WBStrain00034369 | |||||||
WBStrain00000464 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (26) | |||||||
Ortholog (37) | |||||||
Paralog (12) | |||||||
Structured_description | Concise_description | blmp-1 encodes a zinc finger and SET domain-containing protein that is the C. elegans BLIMP1 (B lymphocyte-induced maturation protein 1) ortholog; loss of blmp-1 activity via deletion mutation has been reported to result in small, dumpy animals with abnormal fat content, while loss of blmp-1 activity via RNAi reportedly results in animals that are small, dumpy, have an amorphous pharynx, and are uncoordinated with patchy coloration and protruding vulvae; a blmp-1::gfp transcriptional fusion is expressed from late embryogenesis through adulthood and found in a variety of tissues including hypodermis, seam cells, gonad distal tip cells and vulva, ventral nerve cord, amphids and phasmids, and rectal muscles. | Paper_evidence | WBPaper00005654 | |||
WBPaper00006395 | |||||||
WBPaper00029055 | |||||||
WBPaper00030864 | |||||||
WBPaper00040399 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 16 Nov 2011 00:00:00 | ||||||
Automated_description | Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of distal tip cell migration; regulation of developmental process; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Expressed in several structures, including distal tip cell; dorsal nerve cord; enteric muscle; neurons; and tail hypodermis. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung adenocarcinoma; and non-Hodgkin lymphoma (multiple). Is an ortholog of human PRDM1 (PR/SET domain 1). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0080797 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9346) | ||
DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9346) | ||||
DOID:0050745 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9346) | ||||
DOID:3910 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9346) | ||||
DOID:1324 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9346) | ||||
DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9346) | ||||
Molecular_info | Corresponding_CDS | F25D7.3a | |||||
F25D7.3b | |||||||
Corresponding_transcript | F25D7.3a.1 | ||||||
F25D7.3b.1 | |||||||
Other_sequence (27) | |||||||
Associated_feature (13) | |||||||
Gene_product_binds (10744) | |||||||
Transcription_factor | WBTranscriptionFactor000004 | ||||||
Experimental_info | RNAi_result (23) | ||||||
Expr_pattern (15) | |||||||
Drives_construct | WBCnstr00007730 | ||||||
WBCnstr00008157 | |||||||
WBCnstr00012664 | |||||||
WBCnstr00019673 | |||||||
WBCnstr00023092 | |||||||
WBCnstr00035833 | |||||||
WBCnstr00042568 | |||||||
WBCnstr00042569 | |||||||
Construct_product | WBCnstr00007730 | ||||||
WBCnstr00008157 | |||||||
WBCnstr00023092 | |||||||
WBCnstr00035833 | |||||||
WBCnstr00042569 | |||||||
Regulate_expr_cluster | WBPaper00045017:blmp-1(tm548)_downregulated | ||||||
WBPaper00045017:blmp-1(tm548)_upregulated | |||||||
WBPaper00049732:blmp-1(tm548);daf-7(e1372ts)_vs_daf-7(e1372ts)_downregulated | |||||||
WBPaper00049732:blmp-1(tm548);daf-7(e1372ts)_vs_daf-7(e1372ts)_upregulated | |||||||
WBPaper00049732:blmp-1(tm548)_vs_N2_downregulated | |||||||
WBPaper00049732:blmp-1(tm548)_vs_N2_upregulated | |||||||
WBPaper00062347:blmp-1(tm548)_downregulated | |||||||
WBPaper00062347:blmp-1(tm548)_upregulated | |||||||
WBPaper00062715:blmp-1(s71)_downregulated | |||||||
WBPaper00062715:blmp-1(s71)_upregulated | |||||||
Antibody | WBAntibody00002520 | ||||||
WBAntibody00002528 | |||||||
Microarray_results (29) | |||||||
Expression_cluster (181) | |||||||
Interaction (70) | |||||||
Product_binds_matrix | WBPmat00005558 | ||||||
Map_info | Map | I | Position | 4.9856 | Error | 0.009659 | |
Positive | Positive_clone | F25D7 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | 2_point | 464 | |||||
5839 | |||||||
6047 | |||||||
6048 | |||||||
6214 | |||||||
Multi_point (24) | |||||||
Pos_neg_data | 2512 | ||||||
5841 | |||||||
5843 | |||||||
5845 | |||||||
5847 | |||||||
8063 | |||||||
8074 | |||||||
8085 | |||||||
8131 | |||||||
8136 | |||||||
Pseudo_map_position | |||||||
Reference (65) | |||||||
Remark | Sequence connection from [Strohmaier K, Rothman JH] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |