WormBase Tree Display for Gene: WBGene00003837

WBGene00003837 SMap: S_parent: Sequence: T01B11
  Identity: Version: 1
    Name: CGC_name: oat-1
      Sequence_name: T01B11.7
      Molecular_name: T01B11.7
        T01B11.7.1
        CE30160
      Other_name: CELE_T01B11.7 Accession_evidence: NDB BX284604
      Public_name: oat-1
    DB_info: Database: AceView gene 4J230
        WormQTL gene WBGene00003837
        WormFlux gene WBGene00003837
        NDB locus_tag CELE_T01B11.7
        Panther gene CAEEL|WormBase=WBGene00003837|UniProtKB=G5EDU0
          family PTHR24064
        NCBI gene 177649
        RefSeq protein NM_069041.6
        TrEMBL UniProtAcc G5EDU0
        UniProt_GCRP UniProtAcc G5EDU0
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: oat
    Allele (93)
    RNASeq_FPKM (74)
    GO_annotation: 00014764
      00014765
      00111879
      00111880
      00111881
    Ortholog (90)
    Paralog (27)
    Structured_description: Concise_description: oat-1 encodes a transmembrane organic anion transporter; although loss of oat-1 activity via large-scale RNAi screens results in no obvious abnormalities, when expressed in mammalian cells OAT-1 can transport a variety of structurally diverse organic anions via an anion exchange mechanism that is functionally coupled to a sodium-coupled dicarboxylate transporter; by homology with mammalian OAT1 transporters, C. elegans OAT-1 is predicted to function in xenobiotic elimination. Paper_evidence: WBPaper00003716
            WBPaper00004424
            WBPaper00005654
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 19 Jan 2005 00:00:00
      Automated_description: Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Is an ortholog of several human genes including SLC22A17 (solute carrier family 22 member 17); SLC22A6 (solute carrier family 22 member 6); and SLC22A8 (solute carrier family 22 member 8). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3883 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:16261)
      DOID:0112182 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:16261)
  Molecular_info: Corresponding_CDS: T01B11.7
    Corresponding_transcript: T01B11.7.1
    Other_sequence (26)
    Associated_feature: WBsf1017850
      WBsf230432
  Experimental_info: RNAi_result: WBRNAi00052074 Inferred_automatically: RNAi_primary
      WBRNAi00017933 Inferred_automatically: RNAi_primary
      WBRNAi00052075 Inferred_automatically: RNAi_primary
      WBRNAi00034997 Inferred_automatically: RNAi_primary
      WBRNAi00017932 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1013385
      Expr1155705
      Expr2014588
      Expr2032821
    Drives_construct: WBCnstr00035843
    Construct_product: WBCnstr00035843
    Microarray_results (26)
    Expression_cluster (167)
    Interaction (11)
  Map_info: Map: IV Position: 3.83208 Error: 0.002368
    Positive: Positive_clone: T01B11 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00003716
  Remark: Sequence connection from [George RL, Ganapathy V]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene