WormBase Tree Display for Gene: WBGene00003511
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| WBGene00003511 | Evidence | Person_evidence | WBPerson2322 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C49F8 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | mxl-3 | |||||||
| Sequence_name | F46G10.6 | ||||||||
| Molecular_name | F46G10.6 | ||||||||
| F46G10.6.1 | |||||||||
| CE05882 | |||||||||
| Other_name | hlh-23 | Person_evidence | WBPerson346 | ||||||
| CELE_F46G10.6 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | mxl-3 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mxl | ||||||||
| Allele (33) | |||||||||
| Strain | WBStrain00032284 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (36) | |||||||||
| Paralog | WBGene00003509 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00003510 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Structured_description | Concise_description | mxl-3 encodes a basic helix-loop-helix transcription factor; an mxl-3 deletion mutation, tm2580, has been reported to exhibit a slight growth delay; in vitro, MXL-3 binds E-box and/or E-box-like sequences; an mxl-3 reporter fusion is expressed in larvae and adults and seen in head muscles and neurons, part of the intestine, and body hypodermis. | Paper_evidence | WBPaper00034761 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 30 Nov 2009 00:00:00 | ||||||||
| Automated_description | Enables DNA-binding transcription factor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II; regulation of fatty acid biosynthetic process; and response to food. Acts upstream of with a positive effect on insulin receptor signaling pathway. Located in cytoplasm and nucleus. Expressed in AWCL; AWCR; neurons; and pharynx. Used to study diabetes mellitus. Human ortholog(s) of this gene implicated in lung small cell carcinoma and pheochromocytoma. Is an ortholog of human MAX (MYC associated factor X). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:9351 | Homo sapiens | Paper_evidence | WBPaper00053320 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 30 Apr 2018 00:00:00 | ||||||||
| Potential_model | DOID:5409 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6913) | |||||
| DOID:0050771 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6913) | ||||||
| Models_disease_asserted | WBDOannot00000509 | ||||||||
| WBDOannot00000510 | |||||||||
| Molecular_info | Corresponding_CDS | F46G10.6 | |||||||
| Corresponding_transcript | F46G10.6.1 | ||||||||
| Other_sequence | CBC02916_1 | ||||||||
| Hbac_isotig02902 | |||||||||
| XIC03776_1 | |||||||||
| XI03936 | |||||||||
| BXC03138_1 | |||||||||
| JI177401.1 | |||||||||
| BUC01022_1 | |||||||||
| Associated_feature (14) | |||||||||
| Transcription_factor | WBTranscriptionFactor000089 | ||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern | Expr10777 | ||||||||
| Expr10926 | |||||||||
| Expr1025842 | |||||||||
| Expr1031607 | |||||||||
| Expr1151409 | |||||||||
| Expr2013839 | |||||||||
| Expr2032079 | |||||||||
| Drives_construct | WBCnstr00017730 | ||||||||
| WBCnstr00017837 | |||||||||
| WBCnstr00036081 | |||||||||
| Construct_product | WBCnstr00016003 | ||||||||
| WBCnstr00017837 | |||||||||
| WBCnstr00022587 | |||||||||
| WBCnstr00036081 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (222) | |||||||||
| Interaction (56) | |||||||||
| Map_info | Map | X | Position | 11.6963 | Error | 0.120324 | |||
| Positive | Positive_clone | F46G10 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4506 | |||||||
| 4661 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (20) | |||||||||
| Remark | mxl-3 naming is based on high level of sequence identity between F46G10.6 and its human orthologues Max and Mlx [Pickett CL][030331 ck1] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
