WormBase Tree Display for Gene: WBGene00003509

WBGene00003509 SMap: S_parent: Sequence: T19B10
  Identity: Version: 1
    Name: CGC_name: mxl-1
      Sequence_name: T19B10.11
      Molecular_name: T19B10.11
        T19B10.11.1
        CE16417
      Other_name: CELE_T19B10.11 Accession_evidence: NDB BX284605
      Public_name: mxl-1
    DB_info: Database: AceView gene 5L725
        WormQTL gene WBGene00003509
        WormFlux gene WBGene00003509
        NDB locus_tag CELE_T19B10.11
        Panther gene CAEEL|WormBase=WBGene00003509|UniProtKB=G5EEH5
          family PTHR10328
        NCBI gene 179557
        RefSeq protein NM_073455.7
        SwissProt UniProtAcc G5EEH5
        UniProt_GCRP UniProtAcc G5EEH5
        OMIM gene 154950
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:32 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mxl
    Allele (17)
    Legacy_information: [Yuan J, Cole MD] No mutations known. Related to vertebrate MAX transcription factor, MXL-1 can form DNA-binding heterodimer with MDL-1 in vitro. mxl-1::GFP expression strongest in intestinal cells. Predicted gene T19B10.11.
    RNASeq_FPKM (74)
    GO_annotation (18)
    Contained_in_operon: CEOP5280
    Ortholog (28)
    Paralog: WBGene00003511 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: mxl-1 encodes a basic helix-loop-helix protein similar to the vertebrate MAX transcriptional regulators; in vitro, MXL-1 can heterodimerize, and bind an E-box DNA sequence, with MDL-1, a C. elegans MAD-like bHLH protein; mxl-1::gfp reporter fusions are expressed in the posterior intestine and in head and tail neurons. Paper_evidence: WBPaper00003190
          Curator_confirmed: WBPerson1843
          Date_last_updated: 11 Sep 2007 00:00:00
      Automated_description: Enables protein domain specific binding activity and protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Involved in determination of adult lifespan. Located in nucleus. Part of transcription regulator complex. Expressed in tail neurons. Human ortholog(s) of this gene implicated in lung small cell carcinoma and pheochromocytoma. Is an ortholog of human MAX (MYC associated factor X). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:5409 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6913)
      DOID:0050771 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6913)
  Molecular_info: Corresponding_CDS: T19B10.11
    Corresponding_transcript: T19B10.11.1
    Other_sequence (22)
    Associated_feature: WBsf647243
      WBsf978665
      WBsf232485
      WBsf232486
    Transcription_factor: WBTranscriptionFactor000088
      WBTranscriptionFactor000087
  Experimental_info: RNAi_result: WBRNAi00018816 Inferred_automatically: RNAi_primary
      WBRNAi00061886 Inferred_automatically: RNAi_primary
      WBRNAi00115841 Inferred_automatically: RNAi_primary
      WBRNAi00027699 Inferred_automatically: RNAi_primary
      WBRNAi00115664 Inferred_automatically: RNAi_primary
      WBRNAi00053490 Inferred_automatically: RNAi_primary
      WBRNAi00090663 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr701
      Expr1019202
      Expr1031605
      Expr1157055
      Expr2013837
      Expr2032077
    Drives_construct: WBCnstr00012497
      WBCnstr00036082
    Construct_product: WBCnstr00021771
      WBCnstr00036082
    Microarray_results (20)
    Expression_cluster (116)
    SAGE_tag: SAGE:ctcgagaaca Strand: Sense
        Unambiguously_mapped
      SAGE:taaataatat Strand: Antisense
      SAGE:catacacggtagttatt Strand: Antisense
      SAGE:catacacggt Strand: Antisense
      SAGE:ctcgagaacagcacaac Strand: Sense
        Unambiguously_mapped
      SAGE:ctcaataatgtaatgta Strand: Sense
        Unambiguously_mapped
      SAGE:ctcaataatg Strand: Sense
        Unambiguously_mapped
      SAGE:taaaataact Strand: Antisense
      SAGE:ccgcttcgga Strand: Antisense
    Interaction (12)
  Map_info: Map: V Position: 3.0135 Error: 0.004779
    Positive: Positive_clone: T19B10 Author_evidence: Yuan JY
            Cole MD
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4855
        4822
        4225
        4437
    Pseudo_map_position
  Reference (15)
  Remark: Data extracted from Yuan et al. (1998)
    Old name connection to max-1 removed according to [Huang X, Jin Y]. [krb 020614]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene