WormBase Tree Display for Gene: WBGene00003495

WBGene00003495 SMap: S_parent: Sequence: T22E5
  Identity: Version: 1
    Name: CGC_name: mup-2 Person_evidence: WBPerson1052
      Sequence_name: T22E5.5
      Molecular_name: T22E5.5
        T22E5.5.1
        CE04994
      Other_name: tnt-1
        CELE_T22E5.5 Accession_evidence: NDB BX284606
      Public_name: mup-2
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:32 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mup
    Allele (28)
    Legacy_information: [C.elegansII] e2346ts : embryonic temp-shift leads to lethal mispositioning and deformity of body-wall muscle; larval temp-shift leads to sterility, defects in oviduct muscle. OA1: up1 (non-conditional, lethal with arrest as kinked larva; probable null, nonsense mutation). Cloned: encodes troponin T homolog. [EE; UG]
    Strain: WBStrain00006650
      WBStrain00006651
      WBStrain00006652
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog (36)
    Paralog: WBGene00006587 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00006589 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006588 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: mup-2 encodes the muscle contractile protein troponin T ( TnT ) homologous to vertebrate and invertebrate TnT and contains an invertebrate- specific COOH -terminal tail; mup-2 affects embryonic body wall muscle cell contraction, sarcomere organization, cell positioning, regulated muscle contraction in larval and adult body wall muscle, epidermal morphogenesis, and is required for proper function of the hermaphrodite nonstriated oviduct myoepithelial sheath, proper growth, and fertility. Paper_evidence: WBPaper00002414
            WBPaper00003294
            WBPaper00006395
          Curator_confirmed: WBPerson48
          Date_last_updated: 11 Mar 2005 00:00:00
      Automated_description: Predicted to enable tropomyosin binding activity. Involved in several processes, including axonal fasciculation; muscle structure development; and ovulation. Predicted to be part of troponin complex. Human ortholog(s) of this gene implicated in several diseases, including distal arthrogryposis type 2B2; intrinsic cardiomyopathy (multiple); and nemaline myopathy (multiple). Is an ortholog of human TNNT1 (troponin T1, slow skeletal type); TNNT2 (troponin T2, cardiac type); and TNNT3 (troponin T3, fast skeletal type). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (14)
  Molecular_info: Corresponding_CDS: T22E5.5
    Corresponding_transcript: T22E5.5.1
    Other_sequence (140)
    Associated_feature: WBsf654064
      WBsf670625
      WBsf670626
      WBsf1005570
      WBsf1005571
      WBsf1023097
      WBsf237478
      WBsf237479
      WBsf237480
  Experimental_info: RNAi_result (21)
    Expr_pattern: Expr1026876
      Expr1031599
      Expr1157386
      Expr2013825
      Expr2032065
    Drives_construct: WBCnstr00036087
    Construct_product: WBCnstr00036087
    Microarray_results (23)
    Expression_cluster (248)
    Interaction: WBInteraction000000340
      WBInteraction000000746
      WBInteraction000000747
      WBInteraction000009834
      WBInteraction000028544
      WBInteraction000031314
      WBInteraction000114225
      WBInteraction000117611
      WBInteraction000117612
      WBInteraction000117613
      WBInteraction000117616
      WBInteraction000120960
      WBInteraction000135573
      WBInteraction000137984
      WBInteraction000140885
      WBInteraction000151660
      WBInteraction000165757
      WBInteraction000166173
      WBInteraction000166387
      WBInteraction000167116
      WBInteraction000169132
      WBInteraction000169501
      WBInteraction000169536
      WBInteraction000169691
      WBInteraction000173640
      WBInteraction000196144
      WBInteraction000238209
      WBInteraction000249305
      WBInteraction000266232
      WBInteraction000279674
      WBInteraction000286502
      WBInteraction000316513
      WBInteraction000324669
      WBInteraction000342566
      WBInteraction000343630
      WBInteraction000370585
      WBInteraction000374673
      WBInteraction000381882
      WBInteraction000387176
      WBInteraction000387878
      WBInteraction000387948
      WBInteraction000388318
      WBInteraction000412535
      WBInteraction000417034
      WBInteraction000421325
      WBInteraction000443836
      WBInteraction000448562
      WBInteraction000449889
      WBInteraction000451042
      WBInteraction000462134
      WBInteraction000538819
      WBInteraction000539911
      WBInteraction000550969
      WBInteraction000552299
      WBInteraction000552487
      WBInteraction000553354
      WBInteraction000553639
      WBInteraction000554944
      WBInteraction000554945
      WBInteraction000554946
      WBInteraction000559492
      WBInteraction000561697
      WBInteraction000562294
      WBInteraction000562333
      WBInteraction000564074
      WBInteraction000566247
      WBInteraction000566526
      WBInteraction000569414
      WBInteraction000572159
      WBInteraction000572780
      WBInteraction000576604
      WBInteraction000580190
    WBProcess: WBbiopr:00000006
      WBbiopr:00000067
  Map_info: Map: X Position: -2.91797 Error: 0.002167
    Well_ordered
    Positive: Positive_clone: R04A4
        T22E5 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3386
        3694
        3958
  Reference (39)
  Method: Gene