WormBase Tree Display for Gene: WBGene00003464

WBGene00003464 SMap: S_parent: Sequence: F32B6
  Identity: Version: 1
    Name: CGC_name: msp-77 Person_evidence: WBPerson680
      Sequence_name: F32B6.6
      Molecular_name: F32B6.6
        F32B6.6.1
        CE09861
      Other_name: CELE_F32B6.6 Accession_evidence: NDB BX284604
      Public_name: msp-77
    DB_info: Database: AceView gene 4K659
        WormQTL gene WBGene00003464
        WormFlux gene WBGene00003464
        NDB locus_tag CELE_F32B6.6
        Panther gene CAEEL|WormBase=WBGene00003464|UniProtKB=Q9TVW5
          family PTHR22920
        NCBI gene 177844
        RefSeq protein NM_069380.5
        SwissProt UniProtAcc Q9TVW5
        UniProt_GCRP UniProtAcc Q9TVW5
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:32 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: msp
    Allele: WBVar01500079
      WBVar01856404
      WBVar01498996
      WBVar01499925
      WBVar00433032
      WBVar00934603
      WBVar00934604
      WBVar00934605
      WBVar01500245
    Legacy_information: [C.elegansII] NMK. Encodes MSP (16kD); defines cluster of 3 genes, 3 pseudogenes. [Ward et al. (1988); BA]
    RNASeq_FPKM (74)
    GO_annotation: 00096811
      00096812
      00096813
      00096814
      00096815
      00096816
      00096817
      00096818
    Ortholog (32)
    Paralog (50)
    Structured_description: Concise_description: msp-77 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. Paper_evidence: WBPaper00001023
            WBPaper00002143
            WBPaper00003113
            WBPaper00004591
            WBPaper00005670
          Curator_confirmed: WBPerson324
          Date_last_updated: 17 May 2005 00:00:00
      Automated_description: Involved in oocyte maturation; positive regulation of MAPK cascade; and positive regulation of smooth muscle contraction. Predicted to be located in cytoplasm; cytoskeleton; and pseudopodium. Expressed in gonad; oocyte; and sperm. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F32B6.6
    Corresponding_transcript: F32B6.6.1
    Other_sequence (36)
    Associated_feature: WBsf228898
  Experimental_info: RNAi_result (20)
    Expr_pattern: Expr3417
      Expr1012537
      Expr1150000
      Expr2013789
      Expr2032027
    Drives_construct: WBCnstr00036103
    Construct_product: WBCnstr00036103
    Antibody: WBAntibody00000037
      WBAntibody00000038
      WBAntibody00000854
      WBAntibody00000855
      WBAntibody00000856
      WBAntibody00000857
      WBAntibody00000858
    Microarray_results: SMD_F32B6.6
      Aff_F32B6.6
      GPL14144_F32B6.6_48-107_0.926_1_A
      GPL3518_CE09861
      GPL8673_F32B6_6P00018
    Expression_cluster: WBPaper00029047:atx-3_upregulated
      WBPaper00035269:cde-1_regulated
      WBPaper00036231:long-telomeres_downregulated
      WBPaper00038118:aak-2(gt33)_downregulated
      WBPaper00038237:age-1_upregulated_intestine_rescue
      WBPaper00038237:age-1_upregulated_neuron_rescue
      WBPaper00038237:age-1_upregulated_nontransgenic
      WBPaper00038289:oocyte_protein
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00041954:ethanol_upregulated
      WBPaper00042194:nhr-114(RNAi)_upregulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00042477:prp-8(RNAi)_downregulated_RNAseq
      WBPaper00043945:MeHg_downregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044616:alg-3-4_downregulated_gene
      WBPaper00044743:wdr-23_neuron_upregulated
      WBPaper00044760:germline_specific
      WBPaper00045314:S.aureus-induced_hlh-30(tm1978)
      WBPaper00045521:Spermatogenic
      WBPaper00045729:gld-2(RNAi)_upregulated
      WBPaper00046012:tdp-1(ok803)_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00046795:starvation_upregulated
      WBPaper00046805:csr-1(RNAi)_upregulated_Set1
      WBPaper00046805:csr-1(RNAi)_upregulated_Set2
      WBPaper00046805:P-granule-RNAi_upregulated_Set1
      WBPaper00046805:P-granule-RNAi_upregulated_Set2
      WBPaper00048611:MnCl2_downregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049417:B.animalis_upregulated
      WBPaper00049489:AMsh-glia_enriched
      WBPaper00049498:npr-1(ur89)_regulated_2
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049905:Age_variant_expression
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00050182:lmn-1(L535P)_downregulated
      WBPaper00050231:male_enriched
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00051404:alg-2(ok304)_downregulated
      WBPaper00051404:alg-5(ram2)_downregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053318:Aging_downregulated_mRNA_N2
      WBPaper00053318:mir-71(n4115)_downregulated_mRNA
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00054477:cisplatin_downregulated
      WBPaper00054872:egl-9(sa307)_downregulated
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055354:Rapamycin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055386:eat-2(ad465)_upregulated
      WBPaper00055648:sperm_expressed
      WBPaper00055804:FBF-1-FBF-2-associated_spermatogenic-enriched
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00055971:nhl-2(ok818)_20C_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056167:Cry5B_downregulated
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056731:human-amylin_downregulated
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057288:iff-1(RNAi)_upregulated_protein
      WBPaper00057347:nhr-14(tm1473)_upreglated
      WBPaper00058948:npr-8(ok1439)_downregulated_PA14
      WBPaper00058948:PA14_upregulated
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059175:hlh-17p-XBP-1_upregulated
      WBPaper00059253:sucrose_stearic-acid_downregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059328:mrps-5(RNAi)_upregulated_protein
      WBPaper00059334:sacy-1(depletion)_regulated
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059426:Ag-nanoparticles_upregulated
      WBPaper00059426:SiO2-nanoparticles_upregulated
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059605:mut-16(pk710)_upregulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00059739:hira-1(gk835598)_downregulated_adult
      WBPaper00059739:hira-1(gk835598)_upregulated_L4
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060526:plp-1(ok2155)_upregulated
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060744:Radiation_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060871:M.humicola-infection_48h_regulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00060921:cat-2(e1112)_downregulated
      WBPaper00060921:tbh-1(ok1196)_downregulated
      WBPaper00061040:eat-2(ad1116)_downregulated
      WBPaper00061045:Y56A3A.22(cck200)_upregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061424:Diet_MYb131_upregulated
      WBPaper00061478:pie-1(ne4433)_upregulated
      WBPaper00061479:hda-1(ne4747)_upregulated
      WBPaper00061479:hda-1(ne4748)_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061479:prg-1(tm872)_upregulated
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:msp-36-msp-55
      WBPaper00061572:oleic-acid-specific_mating_upregulated
      WBPaper00061651:Sperm_enriched
      WBPaper00061853:osm-3(dh441)_downregulated
      WBPaper00061853:osm-3(dh441)_downregulated_tunicamycin
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00061995:mter-4(syb3662syb3403)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062456:doxycycline_upregulated_CB4856_transcript
      WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064107:lin-35(n745)_downregulated
      WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
      WBPaper00064130:Beta-Amyloid_downregulated_protein
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064494:postdauer_downregulated_WholeAnimal
      WBPaper00064502:nhr-23(kry61);spe-44(fx110)_downregulated
      WBPaper00064539:nhr-114(gk849)_downregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064721:fasn-1(g14)_upregulated_starved
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064789:Day6_vs_Day1_downregulated_neuron
      WBPaper00064952:Day1_vs_L4_upregulated_20C
      WBPaper00064952:Day1_vs_L4_upregulated_25C
      WBPaper00064952:Day5_vs_Day1_downregulated_20C
      WBPaper00064952:Day5_vs_Day1_downregulated_25C
      WBPaper00064952:Day10_vs_Day1_downregulated_20C
      WBPaper00064952:Day10_vs_Day1_downregulated_25C
      WBPaper00064999:miR-229-64-65-66_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C
      WBPaper00065096:npr-8(ok1439)_upregulated_Day10_20C
      WBPaper00065096:npr-8(ok1439)_upregulated_Day10_25C
      WBPaper00065158:AFD_depleted
      WBPaper00065734:unc-25(e156)_downregulated
      WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_upregulated_N2
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00066038:mip-1(how5)_upregulated
      WBPaper00066085:hda-3(ok1991)_upregulated
      WBPaper00066110:Cisplatin_upregulated_diploid
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
      cgc4386_cluster_1_2
      cgc4489_group_11
      WBPaper00025099:MA_specific
      WBPaper00026629:L3_male_enriched
      WBPaper00031184:acrylamide_upregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(83_min)
      [cgc5767]:expression_class_E_pi(83_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SET
      [cgc5767]:expression_class_SE_pi(83_min)
      [cgc6390]:Cluster_D
      [cgc6390]:spermatogenesis-enriched
    Interaction (217)
  Map_info: Map: IV Position: 4.4394 Error: 0.000573
    Positive: Positive_clone: C01D10
        F32B6 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00001023
    WBPaper00004591
    WBPaper00014039
    WBPaper00024312
    WBPaper00028730
    WBPaper00040308
    WBPaper00057218
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene