WormBase Tree Display for Gene: WBGene00003390
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| WBGene00003390 | SMap | S_parent | Sequence | H20J04 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | mog-2 | Paper_evidence | WBPaper00038354 | |||||
| Person_evidence | WBPerson320 | ||||||||
| Sequence_name | H20J04.8 | ||||||||
| Molecular_name | H20J04.8 | ||||||||
| H20J04.8.1 | |||||||||
| CE20974 | |||||||||
| Other_name | sap-1 | Person_evidence | WBPerson71 | ||||||
| WBPerson395 | |||||||||
| tag-247 | Person_evidence | WBPerson201 | |||||||
| CELE_H20J04.8 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | mog-2 | ||||||||
| DB_info | Database | WormFlux | gene | WBGene00003390 | |||||
| NDB | locus_tag | CELE_H20J04.8 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003390|UniProtKB=Q9BLB6 | |||||||
| family | PTHR10552 | ||||||||
| NCBI | gene | 173767 | |||||||
| RefSeq | protein | NM_062362.6 | |||||||
| SwissProt | UniProtAcc | Q9BLB6 | |||||||
| TREEFAM | TREEFAM_ID | TF313776 | |||||||
| UniProt_GCRP | UniProtAcc | Q9BLB6 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 05 May 2011 12:04:42 | WBPerson2970 | Event | Acquires_merge | WBGene00044076 | ||||
| Name_change | Sequence_name | H20J04.8 | |||||||
| Other_name | sap-1 | ||||||||
| Acquires_merge | WBGene00044076 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mog | ||||||||
| Allele (55) | |||||||||
| Legacy_information | [Graham PL] ts Mog at 25 degrees, hermaphrodite germline makes mostly sperm, rare abnormal oocytes. Mostly fertile at 15 degrees, but no viable progeny (Mel). Also Mel if feminized by fem-3. NA1. | ||||||||
| [C.elegansII] q75 : ts Mog, at 25C hermaphrodite germline makes mostly sperm, rare abnormal oocytes. Mostly fertile at 15 degrees, but no viable progeny (Mel). Also Mel if feminized by fem-3. NA1. [Graham et al. 1993] | |||||||||
| Strain | WBStrain00022554 | ||||||||
| WBStrain00036069 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (17) | |||||||||
| Contained_in_operon | CEOP2124 | ||||||||
| Ortholog (35) | |||||||||
| Structured_description | Concise_description | mog-2 encodes a U2 snRNP protein that functions as a component of a ubiquitous machinery used for the sperm/oocyte switch during hermaphrodite germline development; mog-2 is defined by a single mutation that results in masculinization of the germ line at 25 degrees C, and maternal-effect embryonic and larval lethality at 15 degrees C; genetic epistasis tests indicate that mog-2, like other mog loci, is required for 3'-UTR-mediated repression of the sex determining gene fem-3; in addition, temperature-shift experiments indicate that mog-2 activity is required during the L4 larval stage and into adulthood for normal germline development and throughout adult life for oogenesis; mog-2 not only affects the sperm/oocyte switch in the germ line, but also functions in somatic tissues. | Paper_evidence | WBPaper00001883 | |||||
| WBPaper00003271 | |||||||||
| WBPaper00038354 | |||||||||
| Curator_confirmed | WBPerson12884 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 23 Aug 2011 00:00:00 | ||||||||
| Automated_description | Enables U2 snRNA binding activity. Involved in feminization of hermaphroditic germ-line; germline cell cycle switching, mitotic to meiotic cell cycle; and mRNA 3'-splice site recognition. Located in nucleoplasm. Part of U2 snRNP. Human ortholog(s) of this gene implicated in connective tissue disease. Is an ortholog of human SNRPA1 (small nuclear ribonucleoprotein polypeptide A'). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:65 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11152) | ||||
| Modifies_disease | DOID:0110403 | ||||||||
| Modifies_disease_in_annotation | WBDOannot00001211 | ||||||||
| Molecular_info | Corresponding_CDS | H20J04.8 | |||||||
| Corresponding_transcript | H20J04.8.1 | ||||||||
| Other_sequence (39) | |||||||||
| Associated_feature | WBsf657458 | ||||||||
| WBsf221109 | |||||||||
| WBsf221110 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr9284 | ||||||||
| Expr9285 | |||||||||
| Expr1031562 | |||||||||
| Expr1153175 | |||||||||
| Expr2013649 | |||||||||
| Expr2031883 | |||||||||
| Antibody | WBAntibody00002226 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (119) | |||||||||
| Interaction (23) | |||||||||
| Map_info | Map | II | Position | -4.88055 | Error | 0.016982 | |||
| Positive | Positive_clone | H20J04 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 2790 | |||||||
| 5349 | |||||||||
| 4377 | |||||||||
| 5292 | |||||||||
| Pos_neg_data | 7380 | ||||||||
| Reference (19) | |||||||||
| Remark | data extracted from Graham, Schedl & Kimble 1993 | ||||||||
| Method | Gene |
