WormBase Tree Display for Gene: WBGene00003387

WBGene00003387 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: Y54E10BR
  Identity: Version: 1
    Name: CGC_name: mod-5 Person_evidence: WBPerson268
      Sequence_name: Y54E10BR.7
      Molecular_name: Y54E10BR.7
        Y54E10BR.7.1
        CE28995
      Other_name: Y54E10BR.b Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_Y54E10BR.7 Accession_evidence: NDB BX284601
      Public_name: mod-5
    DB_info: Database: AceView gene 1D604
        WormQTL gene WBGene00003387
        WormFlux gene WBGene00003387
        NDB locus_tag CELE_Y54E10BR.7
        Panther gene CAEEL|WormBase=WBGene00003387|UniProtKB=Q9N3C7
          family PTHR11616
        NCBI gene 171879
        RefSeq protein NM_058694.4
        TrEMBL UniProtAcc Q9N3C7
        UniProt_GCRP UniProtAcc Q9N3C7
        OMIM gene 182138
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:31 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mod
    Allele: WBVar00090682 Inferred_automatically: From strain object: MT11190
          From strain object: MT9772
      WBVar00097484
      WBVar02035186
      WBVar02035187
      WBVar02028370
      WBVar02028371
      WBVar02028372
      WBVar02106076
      WBVar02028373
      WBVar00329687
      WBVar01421145
      WBVar01391747
      WBVar00329688
      WBVar00329689
      WBVar01421146
      WBVar01391748
      WBVar01421148
      WBVar00329690
      WBVar01421149
      WBVar00329691
      WBVar01421150
      WBVar00329692
      WBVar00329693
      WBVar01421152
      WBVar00329694
      WBVar01421159
      WBVar00308618
      WBVar00329695
      WBVar01421161
      WBVar00329696
      WBVar01421162
      WBVar01421164
      WBVar00329697
      WBVar00329698
      WBVar01421166
      WBVar01265029
      WBVar00329699
      WBVar00329700
      WBVar01421168
      WBVar00329701
      WBVar01421169
      WBVar01421172
      WBVar00329702
      WBVar01398835
      WBVar00329703
      WBVar01421174
      WBVar00329704
      WBVar01421175
      WBVar01421176
      WBVar00329705
      WBVar01421177
      WBVar00329706
      WBVar01421179
      WBVar00329707
      WBVar01421180
      WBVar01421182
      WBVar01421183
      WBVar01704836
      WBVar01421184
      WBVar01602787
      WBVar01421185
      WBVar01602788
      WBVar01414411
      WBVar01421188
      WBVar01421193
      WBVar01602789
      WBVar01411335
      WBVar01602790
      WBVar01421194
      WBVar01602791
      WBVar00028751
      WBVar01421195
      WBVar01602792
      WBVar01691737
      WBVar01602793
      WBVar01602794
      WBVar01691738
      WBVar01691739
      WBVar01602795
      WBVar01602796
      WBVar01691740
      WBVar01414422
      WBVar01762164
      WBVar01762165
      WBVar01414433
      WBVar01762166
      WBVar01762167
      WBVar01762168
      WBVar01762169
      WBVar01762170
      WBVar01762171
      WBVar01414444
      WBVar01762172
      WBVar01762173
      WBVar01500504
      WBVar01762174
      WBVar01762175
      WBVar01490947
      WBVar01264805
      WBVar01430889
      WBVar01430891
      WBVar01430892
      WBVar01982044
      WBVar01531728
      WBVar01982045
      WBVar01430893
      WBVar01531729
      WBVar01982047
      WBVar01430894
      WBVar01430895
      WBVar01430897
      WBVar01499786
      WBVar01430898
      WBVar02045447
      WBVar01693803
      WBVar01430899
      WBVar01693804
      WBVar01430900
      WBVar00151609
      WBVar00151610
      WBVar00316055
      WBVar00151611
      WBVar00151612
      WBVar00151613
      WBVar01573898
      WBVar00151614
      WBVar00029451
      WBVar00151615
      WBVar00151616
      WBVar00151617
      WBVar00151618
      WBVar00623849
      WBVar00623850
      WBVar01499985
      WBVar00151619
      WBVar00151620
      WBVar00623851
      WBVar00623852
      WBVar00151621
      WBVar00151622
      WBVar00623853
      WBVar00151623
      WBVar02126773
      WBVar00623854
      WBVar02126774
      WBVar00151624
      WBVar00623855
      WBVar02126775
      WBVar00151625
      WBVar00623856
      WBVar02126776
      WBVar00623857
      WBVar00151626
      WBVar00623858
      WBVar00151627
      WBVar01403066
      WBVar00151628
      WBVar00623859
      WBVar01403070
      WBVar00151629
      WBVar00623860
      WBVar01498892
      WBVar00151630
      WBVar01909475
      WBVar00623861
      WBVar01909476
      WBVar00623862
      WBVar00623863
      WBVar00247603
      WBVar00623864
      WBVar00535670
      WBVar00623865
      WBVar00535671
      WBVar00623866
      WBVar00535673
      WBVar01280229
      WBVar01280230
      WBVar00623867
      WBVar00535674
      WBVar01849662
      WBVar00535676
      WBVar01280231
      WBVar00623868
      WBVar00304898
      WBVar00307448
      WBVar00623869
      WBVar00535679
      WBVar01280232
      WBVar00535680
      WBVar01280233
      WBVar00623870
      WBVar00535682
      WBVar01911516
      WBVar01280234
      WBVar00623871
      WBVar01265140
      WBVar00623872
      WBVar00623873
      WBVar00623874
      WBVar00623875
      WBVar00623876
      WBVar01817421
      WBVar00623877
      WBVar01817422
      WBVar00623878
      WBVar01817423
      WBVar01817424
      WBVar00623879
      WBVar01817425
      WBVar01475174
      WBVar00623880
      WBVar01817426
      WBVar01475175
      WBVar00623881
      WBVar01817427
      WBVar01475176
      WBVar00623882
      WBVar00623883
      WBVar01817428
      WBVar01662681
      WBVar00623884
      WBVar01817429
      WBVar00623885
      WBVar01817430
      WBVar01956582
      WBVar01817431
      WBVar00623886
      WBVar00623887
      WBVar01788490
      WBVar01788491
      WBVar00623888
      WBVar00623889
      WBVar00623890
      WBVar00623891
      WBVar00623892
      WBVar00623893
      WBVar01801236
      WBVar00623894
      WBVar00623895
      WBVar00623896
      WBVar00623897
      WBVar01264916
      WBVar00623898
      WBVar00623899
      WBVar01341613
      WBVar00623900
      WBVar00623901
      WBVar01341614
      WBVar00623902
      WBVar01341616
      WBVar01341618
      WBVar00623903
      WBVar00623904
      WBVar01341621
      WBVar00623905
      WBVar00623906
      WBVar01341627
      WBVar01341628
      WBVar00623907
      WBVar00623908
      WBVar00089790
      WBVar00089791
      WBVar00623909
      WBVar01341642
      WBVar00623910
      WBVar00623911
      WBVar01341646
      WBVar00623912
      WBVar00623913
      WBVar01265251
      WBVar00623914
      WBVar00623915
      WBVar00623916
      WBVar00623917
      WBVar00623918
      WBVar00623919
      WBVar02148406
      WBVar00623920
      WBVar01264694
      WBVar00623921
      WBVar00623922
      WBVar00623923
      WBVar00623924
      WBVar01894746
      WBVar01489944
    Legacy_information: [Ranganathan R] Modulation of locomotion defective. Hypersensitive to serotonin in assays of locomotion.
    Strain: WBStrain00027352
      WBStrain00027366
      WBStrain00027389
      WBStrain00006656
      WBStrain00051808
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog (39)
    Paralog (13)
    Structured_description: Concise_description: mod-5 encodes a Na[+],Cl[-]-dependent serotonin transporter that is required for serotonin uptake by neurosecretory motor neurons and for the experience-dependent enhanced slowing response to food; MOD-5 has serotonin transport activity in cell culture, and is a target of the serotonin uptake inhibitor fluoxetine (Prozac) in vivo; MOD-5 is orthologous to the human serotonin transporter (SLC6A4, OMIM:182138, associated with varying levels of neuroticism, introversion, and anxiety). Paper_evidence: WBPaper00004809
          Curator_confirmed: WBPerson1823
            WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables serotonin:sodium:chloride symporter activity. Involved in serotonin uptake. Predicted to be located in neuron projection. Expressed in several structures, including nerve ring. Used to study cocaine abuse. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; alexithymia; and attention deficit hyperactivity disorder. Is an ortholog of human SLC6A4 (solute carrier family 6 member 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:809 Homo sapiens Paper_evidence: WBPaper00034643
          Curator_confirmed: WBPerson324
          Date_last_updated: 28 May 2019 00:00:00
    Potential_model (23)
  Models_disease_asserted: WBDOannot00000682
  Molecular_info: Corresponding_CDS: Y54E10BR.7
    Corresponding_transcript: Y54E10BR.7.1
    Other_sequence: JI182100.1
      ACC22817_1
      ES672715.1
      CRC04707_1
      Dviv_isotig27782
      SS01616
      CR06131
    Associated_feature: WBsf664007
      WBsf717471
      WBsf983050
      WBsf983051
      WBsf983052
      WBsf1009445
      WBsf1009446
      WBsf219092
      WBsf219093
  Experimental_info: RNAi_result: WBRNAi00057365 Inferred_automatically: RNAi_primary
      WBRNAi00113742 Inferred_automatically: RNAi_primary
      WBRNAi00113746 Inferred_automatically: RNAi_primary
      WBRNAi00004736 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr9349
      Expr9350
      Expr9351
      Expr1029124
      Expr1160802
      Expr2013646
      Expr2031880
    Drives_construct: WBCnstr00013917
      WBCnstr00013918
    Antibody: WBAntibody00002265
    Microarray_results (18)
    Expression_cluster (95)
    Interaction: WBInteraction000001398
      WBInteraction000001399
      WBInteraction000029562
      WBInteraction000031265
      WBInteraction000162267
      WBInteraction000162559
      WBInteraction000165837
      WBInteraction000166111
      WBInteraction000426665
      WBInteraction000471671
  Map_info: Map: I Position: -4.51354 Error: 0.034726
    Well_ordered
    Positive: Positive_clone: Y54E10A_154
        Y54E10BR Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3833
        3831
        3834
        3835
        3873
        3832
  Reference (79)
  Remark: mod-5 was once called dmo-5. Y54E10BR.7 is the real CGC-approved mod-5, and all the Ranganathan genetic mapping data belong to it, as mod-5, reference allele n822. The gene dmo-5 (reference allele t1502, cgc3363) is something different, but was originally incorrectly published. The allele t1502 is therefore, deleted from mod-5 CGC_data_submission
  Method: Gene