WormBase Tree Display for Gene: WBGene00003246
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| WBGene00003246 | SMap | S_parent | Sequence | R06B9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | mig-14 | Paper_evidence | WBPaper00027609 | |||||
| Person_evidence | WBPerson261 | ||||||||
| Sequence_name | R06B9.6 | ||||||||
| Molecular_name | R06B9.6 | ||||||||
| R06B9.6.1 | |||||||||
| CE34955 | |||||||||
| Other_name | mom-3 | Paper_evidence | WBPaper00027609 | ||||||
| let-553 | |||||||||
| pvl-2 | |||||||||
| CELE_R06B9.6 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | mig-14 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 24 May 2006 11:10:00 | WBPerson2970 | Event | Acquires_merge | WBGene00011057 | ||||
| Name_change | Sequence_name | R06B9.6 | |||||||
| Acquires_merge | WBGene00011057 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mig | ||||||||
| Allele (434) | |||||||||
| Legacy_information | [Schlesinger A] phenotypes vary by allele. or78: zygotic defects: homozygotes slightly unc and display vulva defect (the gonad blows out through the vulva opening in young adults). Vulva defect supressed by lin-7 (blocking the vulva). 100% maternal-effect lethal, with 65% of embryos from homozygous mothers lacking endoderm and having excess mesoderm. mom-3 is required in P2 for endoderm induction and EMS spindle orientation. | ||||||||
| [Eisenmann DM] some vulval precursor cells (VPCs) fail to divide leading to fewer than 22 vulval cells formed and an Egl or Pvl (protruding vulva) phenotype. P12.p to P11.p cell fate transformation, abnormal gonad migration, poor male mating, slightly Unc. | |||||||||
| [Honigberg LA] QL descendants migrate to anterior, QR descendants and HSNs have shortened migrations, BDU posteriorly displaced. Mild Egl. | |||||||||
| [C.elegansII] mu71 : QL descendants migrate to anterior, QR descendants and HSNs have shortened migrations, BDU posteriorly displaced. Mild Egl. [CF] | |||||||||
| [Hodgkin JA ] e2617 is mut-2 induced. Hermaphrodites reach sterile adulthood, non-Unc, Evl, often rupture at L4 molt. Sperm present, many abnormal oocytes, Mel, variable arrest up to many cells, no morphogenesis. Many distorted eggs, never laid. More rupture at 25C. Males have sperm, fan, rays, very malformed tail, spicules absent or almost absent (slight sclerotization). | |||||||||
| Complementation_data | [Schlesinger A] does not complement mom-3 (zu21), let-553 (e2617), pvl-2 (ga62) or mig-14 (k124) | ||||||||
| [Eisenmann DM] ga62 fails to complement mig-14(mu71) for Egl phenotype. ga62 fails to complement mom-3(or78) for embryonic lethal phenotype. | |||||||||
| Strain | WBStrain00004822 | ||||||||
| WBStrain00007272 | |||||||||
| WBStrain00007433 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (41) | |||||||||
| Ortholog (43) | |||||||||
| Structured_description | Concise_description | mig-14 encodes a novel, seven-transmembrane domain protein orthologous to Drosophila and human Wntless; mig-14 functions in many Wnt-related processes including endoderm induction and spindle orientation in the early embryo and later in vulval precursor cell fate specification; in the early embryo, mig-14 activity is required within Wnt-signaling cells, consistent with its proposed role in regulation of Wnt secretion; mig-14 also affects the migration of several different cell types during development including the Q neuroblasts along the anterior/posterior axis of the body, the distal tip cells in the gonad, the HSN, and the male linker cell; mig-14 is required for the expression of mab-5 which along with lin-39 regulates migration of cells in the Q lineages; mig-14 also acts independently of mab-5 to affect the final positioning of the Q descendants. | Paper_evidence | WBPaper00002582 | |||||
| WBPaper00002870 | |||||||||
| WBPaper00003383 | |||||||||
| WBPaper00003598 | |||||||||
| WBPaper00003645 | |||||||||
| WBPaper00004436 | |||||||||
| WBPaper00027609 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 06 Dec 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable Wnt-protein binding activity. Involved in several processes, including Wnt signaling pathway; embryonic morphogenesis; and left/right axis specification. Located in basolateral plasma membrane and cytoplasmic vesicle. Expressed in several structures, including CAN; anal region; intestinal muscle; tail hypodermis; and ventral nerve cord. Is an ortholog of human WLS (Wnt ligand secretion mediator). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070473 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:30238) | ||||
| Molecular_info | Corresponding_CDS | R06B9.6 | |||||||
| Corresponding_transcript | R06B9.6.1 | ||||||||
| Other_sequence (50) | |||||||||
| Associated_feature | WBsf990503 | ||||||||
| WBsf222387 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00101489 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00099143 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00065890 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00099142 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00005806 | ||||||||
| WBCnstr00009253 | |||||||||
| WBCnstr00009283 | |||||||||
| Construct_product | WBCnstr00005806 | ||||||||
| WBCnstr00007655 | |||||||||
| WBCnstr00009186 | |||||||||
| WBCnstr00009187 | |||||||||
| WBCnstr00009253 | |||||||||
| WBCnstr00009283 | |||||||||
| WBCnstr00014995 | |||||||||
| WBCnstr00038126 | |||||||||
| WBCnstr00038423 | |||||||||
| WBCnstr00039965 | |||||||||
| Antibody | WBAntibody00002568 | ||||||||
| WBAntibody00002569 | |||||||||
| Microarray_results (14) | |||||||||
| Expression_cluster (130) | |||||||||
| Interaction (54) | |||||||||
| Anatomy_function | WBbtf0747 | ||||||||
| WBbtf0778 | |||||||||
| WBbtf0779 | |||||||||
| WBbtf0780 | |||||||||
| WBbtf0781 | |||||||||
| WBProcess | WBbiopr:00000073 | ||||||||
| Map_info | Map | II | Position | 20.2541 | Error | 0.053576 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | R06B9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Negative | Outside_rearr | mnDf106 | |||||||
| mnDf63 | |||||||||
| mnDf66 | |||||||||
| mnDf109 | |||||||||
| Negative_clone | T05C12 | ||||||||
| Mapping_data | Multi_point | 3561 | |||||||
| 3562 | |||||||||
| 3563 | |||||||||
| 3303 | |||||||||
| 3500 | |||||||||
| 3836 | |||||||||
| 3791 | |||||||||
| 3792 | |||||||||
| 3790 | |||||||||
| Pos_neg_data | 8672 | ||||||||
| 8673 | |||||||||
| 8674 | |||||||||
| 9153 | |||||||||
| 9154 | |||||||||
| 9155 | |||||||||
| 9156 | |||||||||
| Landmark_gene | |||||||||
| Reference (81) | |||||||||
| Picture | WBPicture0000013083 | ||||||||
| WBPicture0000013084 | |||||||||
| Remark | Balanced by mnC1. | ||||||||
| not rescued by cosmid that rescues mig-5 ( pvl-2 shares phenotypes and general location with mig-5, but I was not able to obtain a mig-5 allele to do complementation test. Subsequent Df mapping suggests they are not the same gene). | |||||||||
| ga62 and mu71 fail to complement for a larval phenotype. ga62 and or78 fail to complement for an embryonic phenotype. ga62 has a low penetrance embryonic lethality. Therefore, ga62, mu71 and or78 may be alleles of the same gene (pvl-2/mig-14/mom-3) and ga62 and mu71 may retain more function than or78. One three factor cross located ga62 in the LGII cluster, however all subsequent data is consistent with LGIIR location of mig-14/mom-3. | |||||||||
| Method | Gene |
