WormBase Tree Display for Gene: WBGene00003229
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| WBGene00003229 | SMap | S_parent | Sequence | F53G12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mex-3 | Person_evidence | WBPerson498 | |||||
| Sequence_name | F53G12.5 | ||||||||
| Molecular_name (11) | |||||||||
| Other_name | CELE_F53G12.5 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | mex-3 | ||||||||
| DB_info | Database | AceView | gene | 1A607 | |||||
| WormQTL | gene | WBGene00003229 | |||||||
| WormFlux | gene | WBGene00003229 | |||||||
| NDB | locus_tag | CELE_F53G12.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003229|UniProtKB=H2L067 | |||||||
| family | PTHR23285 | ||||||||
| NCBI | gene | 171607 | |||||||
| RefSeq | protein | NM_058280.9 | |||||||
| NM_001381229.2 | |||||||||
| NM_001306334.3 | |||||||||
| TREEFAM | TREEFAM_ID | TF315107 | |||||||
| TrEMBL | UniProtAcc | H2L067 | |||||||
| V6CKQ3 | |||||||||
| Q95R07 | |||||||||
| UniProt_GCRP | UniProtAcc | H2L067 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mex | ||||||||
| Allele (133) | |||||||||
| Legacy_information | [Draper BW] Maternal effect lethal mutations which results in the production of excess muscle. The excess muscle is derived from the anterior blastomere AB of the two cell stage embryo. | ||||||||
| [C.elegansII] zu142 : maternal effect lethal mutations which results in the production of excess muscle. The excess muscle is derived from the anterior blastomere AB of the two cell stage embryo. OA8: zu155, zu203, zu205, zu208, zu211, etc. Cloned: encodes novel predicted protein with two KH domains. mRNA accumulates at anterior pole of zygote after fertilization. [JJ] | |||||||||
| Strain | WBStrain00022472 | ||||||||
| WBStrain00005763 | |||||||||
| WBStrain00007260 | |||||||||
| WBStrain00022478 | |||||||||
| WBStrain00052165 | |||||||||
| WBStrain00052168 | |||||||||
| WBStrain00052164 | |||||||||
| WBStrain00052166 | |||||||||
| WBStrain00052167 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (44) | |||||||||
| Structured_description | Concise_description | mex-3 encodes two KH domain-containing RNA binding proteins; in the early embryo, maternally provided MEX-3 is required for specifying the identities of the anterior AB blastomere and its descendants, as well as for the identity of the P3 blastomere and proper segregation of the germline P granules; mex-3 mRNA is distributed uniformly in the syncytial core of the adult distal gonad, mature oocytes, and early 1-cell stage embryos, but then becomes more prominent in the AB blastomere and its daughters by the 4-cell stage after which it is rapidly degraded save for the D and P4 blastomeres; MEX-3 protein is also detected uniformly in the cytoplasm of oocytes and 1-cell stage embryos, but like the mRNA, becomes more abundant in AB and its daughters at the 2- and 4-cell stages, respectively, before disappearing; MEX-3 is also detected in association with P granules from the 2-cell stage until the late stages of embryogenesis. | Paper_evidence | WBPaper00002572 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 20 Jun 2005 00:00:00 | ||||||||
| Automated_description | Enables single-stranded RNA binding activity. Involved in several processes, including negative regulation of muscle cell differentiation; organelle inheritance; and regulation of gene expression. Located in P granule. Expressed in distal tip cell and embryonic cell. Is an ortholog of human MEX3A (mex-3 RNA binding family member A) and MEX3B (mex-3 RNA binding family member B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F53G12.5a | |||||||
| F53G12.5b | |||||||||
| F53G12.5c | |||||||||
| Corresponding_transcript | F53G12.5a.1 | ||||||||
| F53G12.5a.2 | |||||||||
| F53G12.5a.3 | |||||||||
| F53G12.5b.1 | |||||||||
| F53G12.5c.1 | |||||||||
| Other_sequence (40) | |||||||||
| Associated_feature (25) | |||||||||
| Gene_product_binds | WBsf034245 | ||||||||
| WBsf899526 | |||||||||
| WBsf899527 | |||||||||
| WBsf899528 | |||||||||
| WBsf899529 | |||||||||
| WBsf899542 | |||||||||
| WBsf899543 | |||||||||
| Transcription_factor | WBTranscriptionFactor000115 | ||||||||
| Experimental_info | RNAi_result (64) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00010925 | ||||||||
| WBCnstr00036175 | |||||||||
| Construct_product (14) | |||||||||
| Regulate_expr_cluster | WBPaper00058598:mex-3(eu149)_downregulated | ||||||||
| WBPaper00058598:mex-3(eu149)_upregulated | |||||||||
| WBPaper00061823:mex-3(spr9)_downregulated | |||||||||
| WBPaper00061823:mex-3(spr9)_upregulated | |||||||||
| WBPaper00061823:mex-3(spr10)_downregulated | |||||||||
| WBPaper00061823:mex-3(spr10)_upregulated | |||||||||
| Antibody | WBAntibody00000124 | ||||||||
| WBAntibody00000125 | |||||||||
| WBAntibody00000126 | |||||||||
| WBAntibody00000153 | |||||||||
| WBAntibody00000154 | |||||||||
| WBAntibody00000470 | |||||||||
| WBAntibody00001406 | |||||||||
| WBAntibody00001531 | |||||||||
| WBAntibody00001532 | |||||||||
| Microarray_results (31) | |||||||||
| Expression_cluster (214) | |||||||||
| Interaction (124) | |||||||||
| WBProcess | WBbiopr:00000017 | ||||||||
| Map_info | Map | I | Position | -19.1652 | Error | 0.00806 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F53G12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 6155 | |||||||
| 7070 | |||||||||
| Multi_point | 2661 | ||||||||
| Pos_neg_data | 7212 | ||||||||
| Reference (128) | |||||||||
| Method | Gene |
