| WBGene00003229 | SMap | S_parent | Sequence | F53G12 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | mex-3 | Person_evidence | WBPerson498 |
| | | Sequence_name | F53G12.5 |
| | | Molecular_name (11) |
| | | Other_name | CELE_F53G12.5 | Accession_evidence | NDB | BX284601 |
| | | Public_name | mex-3 |
| | DB_info | Database | AceView | gene | 1A607 |
| | | | WormQTL | gene | WBGene00003229 |
| | | | WormFlux | gene | WBGene00003229 |
| | | | NDB | locus_tag | CELE_F53G12.5 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00003229|UniProtKB=H2L067 |
| | | | | family | PTHR23285 |
| | | | NCBI | gene | 171607 |
| | | | RefSeq | protein | NM_058280.9 |
| | | | | | NM_001381229.2 |
| | | | | | NM_001306334.3 |
| | | | TREEFAM | TREEFAM_ID | TF315107 |
| | | | TrEMBL | UniProtAcc | H2L067 |
| | | | | | V6CKQ3 |
| | | | | | Q95R07 |
| | | | UniProt_GCRP | UniProtAcc | H2L067 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | mex |
| | Allele (133) |
| | Legacy_information | [Draper BW] Maternal effect lethal mutations which results in the production of excess muscle. The excess muscle is derived from the anterior blastomere AB of the two cell stage embryo. |
| | | [C.elegansII] zu142 : maternal effect lethal mutations which results in the production of excess muscle. The excess muscle is derived from the anterior blastomere AB of the two cell stage embryo. OA8: zu155, zu203, zu205, zu208, zu211, etc. Cloned: encodes novel predicted protein with two KH domains. mRNA accumulates at anterior pole of zygote after fertilization. [JJ] |
| | Strain | WBStrain00022472 |
| | | WBStrain00005763 |
| | | WBStrain00007260 |
| | | WBStrain00022478 |
| | | WBStrain00052165 |
| | | WBStrain00052168 |
| | | WBStrain00052164 |
| | | WBStrain00052166 |
| | | WBStrain00052167 |
| | RNASeq_FPKM (74) |
| | GO_annotation (21) |
| | Ortholog (44) |
| | Structured_description | Concise_description | mex-3 encodes two KH domain-containing RNA binding proteins; in the early embryo, maternally provided MEX-3 is required for specifying the identities of the anterior AB blastomere and its descendants, as well as for the identity of the P3 blastomere and proper segregation of the germline P granules; mex-3 mRNA is distributed uniformly in the syncytial core of the adult distal gonad, mature oocytes, and early 1-cell stage embryos, but then becomes more prominent in the AB blastomere and its daughters by the 4-cell stage after which it is rapidly degraded save for the D and P4 blastomeres; MEX-3 protein is also detected uniformly in the cytoplasm of oocytes and 1-cell stage embryos, but like the mRNA, becomes more abundant in AB and its daughters at the 2- and 4-cell stages, respectively, before disappearing; MEX-3 is also detected in association with P granules from the 2-cell stage until the late stages of embryogenesis. | Paper_evidence | WBPaper00002572 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 20 Jun 2005 00:00:00 |
| | | Automated_description | Enables single-stranded RNA binding activity. Involved in several processes, including negative regulation of muscle cell differentiation; organelle inheritance; and regulation of gene expression. Located in P granule. Expressed in distal tip cell and embryonic cell. Is an ortholog of human MEX3A (mex-3 RNA binding family member A) and MEX3B (mex-3 RNA binding family member B). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | F53G12.5a |
| | | F53G12.5b |
| | | F53G12.5c |
| | Corresponding_transcript | F53G12.5a.1 |
| | | F53G12.5a.2 |
| | | F53G12.5a.3 |
| | | F53G12.5b.1 |
| | | F53G12.5c.1 |
| | Other_sequence (40) |
| | Associated_feature (25) |
| | Gene_product_binds | WBsf034245 |
| | | WBsf899526 |
| | | WBsf899527 |
| | | WBsf899528 |
| | | WBsf899529 |
| | | WBsf899542 |
| | | WBsf899543 |
| | Transcription_factor | WBTranscriptionFactor000115 |
| Experimental_info | RNAi_result (64) |
| | Expr_pattern (11) |
| | Drives_construct | WBCnstr00010925 |
| | | WBCnstr00036175 |
| | Construct_product (14) |
| | Regulate_expr_cluster | WBPaper00058598:mex-3(eu149)_downregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00061823:mex-3(spr9)_downregulated |
| | | WBPaper00061823:mex-3(spr9)_upregulated |
| | | WBPaper00061823:mex-3(spr10)_downregulated |
| | | WBPaper00061823:mex-3(spr10)_upregulated |
| | Antibody | WBAntibody00000124 |
| | | WBAntibody00000125 |
| | | WBAntibody00000126 |
| | | WBAntibody00000153 |
| | | WBAntibody00000154 |
| | | WBAntibody00000470 |
| | | WBAntibody00001406 |
| | | WBAntibody00001531 |
| | | WBAntibody00001532 |
| | Microarray_results (31) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032097:CGH-1-associated-mRNA |
| | | WBPaper00033070:Elbe_upregulated |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00038061:aldicarb_upregulated |
| | | WBPaper00041222:hlh-1(cc561)_upregulated |
| | | WBPaper00041222:unc-120(st364)_upregulated |
| | | WBPaper00041506:AB_enriched |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00044786:emr-1(gk119)_downregulated |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00045618:fbf-1_downregulated |
| | | WBPaper00045618:puf-8_downregulated |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00046012:tdp-1(ok803)_downregulated |
| | | WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_upregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046691:AB_enriched |
| | | WBPaper00048611:MnCl2_downregulated |
| | | WBPaper00048762:FOG-3_associated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049905:Age_variant_expression |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00049954:BPA_downregulated |
| | | WBPaper00050182:lmn-1(L535P)_downregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050522:mafr-1(tm6082)_downregulated |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F1_morc-1(tm6048)_downregulated |
| | | WBPaper00051265:F4_hrde-1(tm1200)_upregulated |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00051310:LIN-41_interacting |
| | | WBPaper00051352:Long-Term-Association-Memory_downregulated |
| | | WBPaper00051461:pig-1(gm344)_upregulated |
| | | WBPaper00051558:fog-2(q71)_regulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053388:dauer_regulated_Cluster2 |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated |
| | | WBPaper00053814:25C_downregulated_OP50 |
| | | WBPaper00053814:25C_downregulated_PY79 |
| | | WBPaper00054191:H3.3(null)_L1_upregulated |
| | | WBPaper00054792:FOG-3_interacting |
| | | WBPaper00055013:hmg-3(bar24)_upregulated |
| | | WBPaper00055049:S.gordonii_downregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin_upregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched |
| | | WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056284:ints-5(RNAi)_downregulated |
| | | WBPaper00056290:hsp-6(mg585)_downregulated |
| | | WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00057154:HeatShock_downregulated_mRNA |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00058725:sftb-1(cer6)_upregulated |
| | | WBPaper00058886:anp-1(ok608)_downregulated |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00059027:neuron-synapses_enriched |
| | | WBPaper00059174:MEG-3_interacting |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059440:LAG-1_interacting_germline |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00059728:5ug_cholesterol_downregulated |
| | | WBPaper00059739:hira-1(gk835598)_upregulated_L4 |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060445:ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_upregulated_L4 |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060871:M.humicola-infection_48h_regulated |
| | | WBPaper00060909:atfs-1(cmh15)_upregulated |
| | | WBPaper00061007:HB101_downregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061045:Y56A3A.22(cck200)_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061274:hypergravity_15xg_upregulated |
| | | WBPaper00061274:microgravity_upregulated |
| | | WBPaper00061340:ADEsh |
| | | WBPaper00061340:ALN |
| | | WBPaper00061340:CEPso |
| | | WBPaper00061340:DB |
| | | WBPaper00061340:Excretory_gland |
| | | WBPaper00061340:G2_and_W_blasts |
| | | WBPaper00061340:Glia |
| | | WBPaper00061340:ILsh_OLLsh_OLQsh |
| | | WBPaper00061340:ILso |
| | | WBPaper00061340:Neuroblast_ASE_ASJ_AUA |
| | | WBPaper00061340:PLM_ALN_great_grandparent |
| | | WBPaper00061527:T24D1.3-egg-1 |
| | | WBPaper00061651:PDB_enriched |
| | | WBPaper00061753:csr-1(tor159)_downregulated_25C |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00062118:neural-HSF-1_upregulated |
| | | WBPaper00062123:DEPS-1_interacting |
| | | WBPaper00062123:GLH-1_interacting |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062446:nhr-8(hd117)_downregulated |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated |
| | | WBPaper00064502:spe-44(fx110)_upregulated |
| | | WBPaper00064505:tamoxifen_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064871:hypoxia_upregulated_F1 |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065373:sek-1(km4)_upregulated_Ref |
| | | WBPaper00065841:1_0 |
| | | WBPaper00065841:57_0 |
| | | WBPaper00065841:57_1 |
| | | WBPaper00065841:132_0 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065984:pals-17(syb3980)_upregulated |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4386_cluster_5_2 |
| | | WBPaper00025032:cluster_114 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035084:L3_enriched_AIN-2_IP |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036130:mir-243_down_regulated |
| | | WBPaper00037147:heatshock_upregulated |
| | | WBPaper00037695:LD_DD_6-day |
| | | WBPaper00037901:GLD-1_mRNA_targets |
| | | WBPaper00038427:lin-54_germline_changed |
| | | WBPaper00040426:CYD-1_CDK-4_upregulated |
| | | WBPaper00040821:Au-NP_regulated |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041002:HF_11d_2.0mM_Up |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041906:I-3690_vs_OP50_3d |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00055435:AuNPs_downregulated |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_downregulated |
| | | [cgc5767]:cluster_1 |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | | [cgc6390]:Cluster_E |
| | | [cgc6390]:oogenesis-enriched |
| | Interaction (124) |
| | WBProcess | WBbiopr:00000017 |
| Map_info | Map | I | Position | -19.1652 | Error | 0.00806 |
| | Well_ordered |
| | Positive | Positive_clone | F53G12 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 6155 |
| | | | 7070 |
| | | Multi_point | 2661 |
| | | Pos_neg_data | 7212 |
| Reference (128) |
| Method | Gene |
